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Published on January 10, 2008

Author: Vittoria

Source: authorstream.com

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Seamless Mini-Capsules:  Seamless Mini-Capsules VPS CORPORATION Capsules:  Capsules What are capsules? Capsules can be filled with liquid, powders, granules and suspension base forms. Encapsulate with capsule materials. Types of capsules Soft capsules. Hard capsules. Main capsule products Antibiotics. Raw materials with bitter tastes and strong odors. Oil-based liquid raw materials. Perfume, spices. Hard Capsules:  Hard Capsules Contents Powders, Granules Benefits Can bypass the tabletting stage to manufacture drugs. Usage Antibiotics, Cold Medicines etc. Part of Health Supplement Soft Capsules (Conventional Type):  Soft Capsules (Conventional Type) Contents Oil form・Oil soluble drugs Benefits Encapsulates oil based drugs without granulation. Contains oil-soluble drugs in non-crystallized form. Increase bioavailability due to liquid dosage. Usage Pharmaceutical, Health Supplements etc. Vitamin E Soft Capsules (Seamless Type):  Soft Capsules (Seamless Type) Contents Oil・Oil-soluble drugs, Water-soluble solution・Suspension. Benefits Can make smaller capsules. (less than 3mm dia.) Clear and glossy spherical capsules. Wider range of packaging forms are available. Versatility in drug dosage forms Increase bioavailability due to liquid dosage. Usage Pharmaceutical and Nutraceutical products. Food and confectionary materials. Mouth refreshers, perfumes etc. Disadvantages of hard and soft capsule products (Seam type):  Disadvantages of hard and soft capsule products (Seam type) Limited range of capsules sizes: difficult to adjust the amount of active ingredients Observed inferior content uniformity of active drugs. Shorter capsule life. Limited manufacturing site/equipment flexibility. Advantages of seamless mini capsules.:  Advantages of seamless mini capsules. Direct encapsulation of liquids. Flexible adjustment of the dosage due to its reduced size Provides a vapor barrier to prevent oxidization of the encapsulated substance. Free coloring of the capsules to increase its value added. Flexible control of the capsule size from 1mm to 8mm (diameter). Low shell ratio to the content volume due to the thin shell wall. Cross section of seamless mini-capsules and hair (80 micron) Comparison between Seamless Capsules and Conventional Soft Capsules.:  Comparison between Seamless Capsules and Conventional Soft Capsules. Shell Ratio  Encapsulation Theory:  Encapsulation Theory Seam Type Seam-Less Type What seamless mini-capsules can do…:  What seamless mini-capsules can do… Prevents fish oil and fatty acids from being oxidized. Stabilization of volatile materials such as flavors. Direct encapsulation of oil based drugs. Direct encapsulation of hydrophilic materials. Direct encapsulation of suspensions. Achieve sustained release effect with the enteric coating of the capsules. Stabilization of the heat sensitive materials. Capsule diameter・Weight・Shell thickness(Shell ratio:10%):  Capsule diameter・Weight・Shell thickness(Shell ratio:10%) Capsule diameter・Weight・Shell thickness (Shell ratio: 20%):  Capsule diameter・Weight・Shell thickness (Shell ratio: 20%) Capsule diameter・Weight・Shell thickness(Shell ratio : 30%):  Capsule diameter・Weight・Shell thickness(Shell ratio : 30%) Types of Seamless Capsules(Part 1):  Types of Seamless Capsules(Part 1) Basic type  The most commonly used form of seamless capsules. Can produce a variety of products by combining raw materials. Material 1 Material 2 Types of Seamless Capsules(Part 2):  Types of Seamless Capsules(Part 2) Powder Coated Capsules  Enables the production of unique products by coating food powders on to the outside of seamless mini-capsules. A flavor can be used as Material 2 to provide improved taste. Material 1 Material 2 Material 3 Types of Seamless Capsules(Part 3):  Types of Seamless Capsules(Part 3) Film Coated Capsule   A variety of film materials can be applied on to the seamless mini-capsules. Enteric release and higher value added products. A unique product appearance can be produced. Material 1 Material 2 Material 4 Types of Seamless Capsules(Part 4):  Types of Seamless Capsules(Part 4) Powder Type  Can produce more effective products by encapsulating powders which dispersed into material 2. Material 1 Material 2 Material 5 Types of Seamless Capsules(Part 5):  Types of Seamless Capsules(Part 5) Multi-layer capsule  Unique products can be created by using two different ingredients for materials 2 and 6. Material 1 Material 2 Material 6 Practical Applications of Seamless Mini-Capsules  (Part-1):  Practical Applications of Seamless Mini-Capsules  (Part-1) Food Functional food that contains flavor oils to control mouth odor Additive flavor capsules for chewing gum, chocolate and candy. Nutraceutical food such as lactobacillus bijidus. Development of totally new product forms. Part of the materials used for confectionery products. Practical Applications of Seamless Mini-Capsules  (Part-2):  Practical Applications of Seamless Mini-Capsules  (Part-2) Pharmaceutical and Non-pharmaceutical Products Mini-capsules enables divided in smaller dosages Enables the ingestion of liquid materials and granules at the same time. Improves the ease of formulating coated encapsulated drugs. Enteric drug formulation Control release drug formulation Stabilization of drugs with strong odors. Stabilization of unstable drugs such as oral vaccines. Practical Applications of Seamless Mini-Capsules  (Part-2):  Practical Applications of Seamless Mini-Capsules  (Part-2) Other industries Cosmetics Toiletry products such as aromatics. Bath oils, detergents. Fertilizer, feed. Seamless Mini-Capsule Machine Spherex:  Seamless Mini-Capsule Machine Spherex VPS CORPORATION Characteristics of Spherex:  Characteristics of Spherex Produces highly spherical, uniform and seamless capsules with diameter of 1~5mm and within 3% weight variation. Can produce capsules with very small liquid volumes; 20mL (Laboratory model)enables testing with high cost active drug. Can easily adjust the shell thickness and produce very thin shell of 30 micrometer. Can apply active ingredients to the shell due to the high precision shell ratio control. Characteristics of Spherex:  Characteristics of Spherex Encapsulation of unstable liquid to improve drug stability. Encapsulated liquids can be coated. Enables high-speed production rate of 2 to 300 capsules per seconds. (velocity) Flexible design modification to meet specific needs and production volumes. Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Vibrator Obtains uniform size & weight Adjust the rate of capsule droplet formation Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Core Liquid Inlet Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Shell Liquid Inlet Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Nozzle Unit Pump delivers the core & shell liquids. These are ejected into cooling liquid forming the seamless mini- capsules. Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Rectifier Obtains a stable flow of cooling liquid. Principles of production of seamless mini-capsule:  Principles of production of seamless mini-capsule Core solution and shell solution are ejected simultaneously from the nozzle. Mini-capsules are formed due to surface tension effect between different solutions. Shell solution is solidified to form shell in cooling solution. Mini-Capsule the shell liquid gels as it flows through the coolant liquid flow Estimated Capsule Output:  Estimated Capsule Output Note: Capsule output rate are reference only, and will be changed depending on the formulation. SPHEREX Production Model:  SPHEREX Production Model Model: SPX-8N  (8 nozzles type)       SPHEREX Production Model:  SPHEREX Production Model Model: SPX- 4NL  (4 nozzles type for larger capsules)       SPHEREX Nozzle:  SPHEREX Nozzle Lab unit 1 nozzle Production unit 2 to 4 nozzles Triple layer nozzle is available as option Larger Capsule Cooling System:  Larger Capsule Cooling System Rotating coolant pipe outlet tube Spiral movement increase the capsule’s residence time in the coolant stream. Capsule Collection Unit:  Capsule Collection Unit Wedge wire Cooling liquid filter Vibration Control System:  Vibration Control System Vibrating control with Strobovision scope helps to maintain accurate capsule size control. SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing SPHEREX Encapsulation Process:  SPHEREX Encapsulation Process Preparation Encapsulation Cooling Oil extraction Drying Sieving Selection Inspection Packing Slide47:  VPS CORPORATION Any Questions? We look forward to the opportunity of working with you.

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