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Education

Published on October 15, 2014

Author: ritapeters

Source: authorstream.com

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PowerPoint Presentation: Pharmacotherapy of Mood Disorders 23 Pharmacotherapy of Depression: 23.7 The mechanism of action of antidepressants involves modulation of neurotransmitter levels in the brain. Pharmacotherapy of Depression Tricyclic Antidepressants: 23.8 Tricyclic antidepressants have been the mainstay for the treatment of depression but have many adverse effects. Tricyclic Antidepressants Prototype Drug Imipramine (Tofranil): Prototype Drug Imipramine (Tofranil) Therapeutic classification ___________________ Pharmacologic classification ____________________ Pregnancy category __ Mechanism of action ____________________ Indications __________________ Contraindications __________________ Precautions __________________ Drug interactions __________________ Prototype Drug Imipramine (Tofranil): Prototype Drug Imipramine (Tofranil) Side effects: Serious adverse effects: Nursing responsibilities: Identify necessary assessments, teaching, interventions and evaluation. Where is there potential harm, or need for risk reduction? Similar Drugs: Similar Drugs Amitriptyline (Elavil) and nortriptyline (Aventyl, Pamelor) Clomipramine (Anafranil) Doxepin (Sinequan) Maprotiline (Ludiomil) Protriptyline (Vivactil) Trimipramine (Surmontil) Selective Serotonin Reuptake Inhibitors: 23.9 Selective serotonin reuptake inhibitors are the drugs of choice for treating depression due to their low incidence of serious adverse effects. Selective Serotonin Reuptake Inhibitors Prototype Drug Fluoxetine (Prozac, Sarafem): Prototype Drug Fluoxetine (Prozac, Sarafem) Therapeutic classification ___________________ Pharmacologic classification ____________________ Pregnancy category __ Mechanism of action ____________________ Indications __________________ Contraindications __________________ Precautions __________________ Drug interactions __________________ Prototype Drug Fluoxetine (Prozac, Sarafem): Prototype Drug Fluoxetine (Prozac, Sarafem) Side effects: Serious adverse effects: Nursing responsibilities: Identify necessary assessments, teaching, interventions and evaluation. Where is there potential harm, or need for risk reduction? Similar Drugs: Similar Drugs Citalopram (Celexa) Escitalopram (Lexapro) Fluvoxamine (Luvox) Paroxetine (Paxil, Pexeva) Sertraline (Zoloft) Atypical Antidepressants: 23.10 Atypical antidepressants are alternatives to the selective serotonin reuptake inhibitors that are prescribed for depression and anxiety disorders. Atypical Antidepressants Prototype Drug Venlafaxine (Effexor): Prototype Drug Venlafaxine (Effexor) Therapeutic classification ___________________ Pharmacologic classification ____________________ Pregnancy category __ Mechanism of action ____________________ Indications __________________ Contraindications __________________ Precautions __________________ Drug interactions __________________ Prototype Drug Venlafaxine (Effexor): Prototype Drug Venlafaxine (Effexor) Side effects: Serious adverse effects: Nursing responsibilities: Identify necessary assessments, teaching, interventions and evaluation. Where is there potential harm, or need for risk reduction? Similar Drugs: Similar Drugs Amoxapine (Asendin) Bupropion (Wellbutrin, Zyban) Desvenlafaxine Duloxetine (Cymbalta) Mirtazapine (Remeron) Nefazodone (Serzone) Trazodone (Desyrel) Vilazodone (Viibryd) Monoamine Oxidase Inhibitors: 23.11 Monamine oxidase inhibitors are effective antidepressants but are seldom used due to potentially serious adverse effects. Monoamine Oxidase Inhibitors Bipolar Disorder: 23.12 Bipolar disorder is a serious psychiatric disorder characterized by extreme mood swings from depression to euphoria. Bipolar Disorder Drugs for Bipolar Disorder: 23.13 Lithium is the conventional therapy for the treatment of bipolar disorder. Drugs for Bipolar Disorder Prototype Drug:Lithium carbonate (Eskalith, Lithobid): Prototype Drug:Lithium carbonate (Eskalith, Lithobid) Therapeutic classification ___________________ Pharmacologic classification ____________________ Pregnancy category __ Mechanism of action ____________________ Indications __________________ Contraindications __________________ Precautions __________________ Drug interactions __________________ Prototype Drug: Lithium carbonate (Eskalith, Lithobid): Prototype Drug: Lithium carbonate (Eskalith, Lithobid) Side effects: Serious adverse effects: Nursing responsibilities: Identify necessary assessments, teaching, interventions and evaluation. Where is there potential harm, or need for risk reduction? Drugs for Bipolar Disorder: 23.14 Antiseizure and atypical antipsychotic agents are used to control symptoms of bipolar disorder. Drugs for Bipolar Disorder Antiseizure Agents: Antiseizure Agents Mood stabilizers for bipolar disorder Valproic acid (Depakene) and divalproex sodium (Depakote ER) Carbamazepine (Tegretal) Lamotrigine (Lamictal) Off-label agents include oxcarbazepine (Trileptal), gabapentin (Neurontin), topiramate (Topamax), clonazepam (Klonopin), lorazepam (Ativan) Atypical Antipsychotics: Atypical Antipsychotics Used to control acute symptoms of mania and as long term mood stabilizer Aripiprazole (Abilify) Olanzapine (Zyprexa) Quetiapine (Seroquel) Risperidone (Risperdal) Ziprasidone (Geodon) Antidepressants: Antidepressants Treat depressed stage of bipolar disorder Tend to cause hypomania or mania Administered with mood stabilizer SSRIs, venlafaxine (Effexor), bupropion (Wellbutrin)

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