Vancomycin

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Information about Vancomycin

Published on March 10, 2014

Author: mftrj1993

Source: slideshare.net

VANCOMYCIN Mohammed – Alrjoub

 General info  Clinical info 1- indications 2- dosage and administration 3- CI 4- DI 5- precautions  Pharmaceutical info: dosage forms and storage conditions

GENERAL INFORMATION  MOA: Cell wall synthesis inhibitor  Antibacterial spectrum: G+ organisms ( most important MRSA and drug resistant enterococci)

CLINICAL INFO: INDICATION  For serious G+ infections or those who have an allergy to penicillin  MRSA and MRSE  Orally for life threatening Clostridium Difficile associated colitis  With aminoglycosides for enterococcal endocarditis

CLINICAL INFO: DOSAGE AND ADMINISTRATION  By slow iv infusion over 60-90 min depending on dose a. 500mg q.6.h over 1h or 1g bid over 100min b. at a rate no more than 10mg/min  Preferred to be intermittent iv inf.  Dose depends on CLcr , age, and B.wt.

CLINICAL INFO: DOSAGE AND ADMINISTRATION  Preparation: 1- Add 10 ml of sterile WFI to a 500 mg vial of Vancomycin powder >> 50 mg/ml 2- Reconstituted solutions containing 500 mg vancomycin must be diluted with at least 100 ml diluent. (NaCl soln. or Dextrose soln.)

CLINICAL INFO: C/I  History of deafness  Renal impairment (adjust dose)

CLINICAL INFO: S/E  Red man syndrome: flushing and shock if infused rapidly  Ototoxicity  Nephrotoxicity  Fever ,chills and phlebitis

CLINICAL INFO: DI  Aminoglycosides, furosemide  Anesthetics: hypersensitivity

PRECAUTIONS  Renal impairment  Rapid infusion  Monitor renal function and hearing  Pregnancy: BM  Breast feeding: oral absorption is poor but problems with bowels normal flora and allergic effects have been reported

PHARMACEUTICAL INFO: DOSAGE FORM AND STORAGE CONDITIONS  Vancocin  Vancoled 500 mg vial  Store in airtight container and protect from light

TEICOPLANIN

GENERAL INFORMATION  Glycopeptide antibiotic  MOA: Cell wall synthesis inhibitor  Antibacterial spectrum: G+ organisms ( most important MRSA and drug resistant enterococci)

CLINICAL INFO: INDICATION  For serious G+ infections or those who have an allergy to penicillin  MRSA and MRSE  Orally for life threatening Clostridium Difficile associated colitis  For endocarditis  Treating infection of the abdominal cavity (peritonitis) associated with peritoneal dialysis.

CLINICAL INFO: DOSAGE AND ADMINISTRATION  ROA: Intraperitoneally, IM, IV (inf and bolus), po  Given once daily after the loading dose  Dose depends on age, CLcr, and wt

CLINICAL INFO: DOSAGE AND ADMINISTRATION  Preperation: 1- add water from the ampoule into the vial (3ml) 2- rotate gently between hands to dissolve the powder be careful not to form foam…. If foam develops leave the soln to stand for 15min 3- dilute with NaCl soln, Lactate Ringers, or Dextrose soln or NaCl with dextrose soln. 4- add lidocaine 0.5 or 1% if IM ** the final soln. is stable for about 24hrs at 2-8◦ c (beware of contamination)

CLINICAL INFO: C/I  Hypersensitivity  Renal impairment (adjust dose)

CLINICAL INFO: S/E  Common: pain, fever, rash, itching, redness of skin, NVD  Hearing loss and balance disorders  Liver and kidney function changes  Rare: change in blood cell count

CLINICAL INFO: DI  Aminoglycosides  furosemide  Amphotericin B  Cyclosporine

PRECAUTIONS  Renal impairment  Allergy to vancomycin (cross-allergy)  Monitor renal function, liver function,hearingand blood  Superinfection  Pregnancy, breast feeding: unknown  Contains 24.8mg Na

PHARMACEUTICAL INFO: DOSAGE FORM AND STORAGE CONDITIONS  Targocid (Sanofi Aventis) 200,400 mg vial  Store under 25◦ c

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