Uterus video

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Information about Uterus video
Health & Medicine

Published on March 3, 2013

Author: doctorbobm

Source: slideshare.net


These are the slides that accompany the video found on www.aboutcancer.com

Cancer of the Uterus or Endometrium Robert Miller MD www.aboutcancer.com

Uterine cancer is the most common gynmalignancy with a 2.6 % lifetime riskThe average age is 61 years. The majority arediagnosed at an early stage (68 percent)


Internal Anatomy of the Uterus fundus body isthmus Internal Endometrium orifice Myometrium cervix Cervical vagina canal

Cross section anatomy of the female pelvis

PET Scans may be more useful than CTscans in GYN cancers

Endometrial cancer – adenocarcinoma of thelining of the uterus1. Ovary, 2. Endometrial Cancer, 3. Uterus, 4. Urinary Bladder, 5.Rectum, 6. Vagina

Prognostic Factors in Endometrial Cancer Stage (has it spread to the cervix, ovaries or lymph nodes) Muscle Invasion (deep invasion in more serious) Grade (higher grade is more serious) Histology (certain types like serous cancer or sarcoma are more serious)

T and N Stage of Uterine CancerT1: confined to the uterus T1a : less than halfway into muscle T1b: deeper than halfT2: into cervix (stromal connective tissue)T3a: into serosa or adnexaT3b: into vagina or parametriumT4a: into bladder or rectumN1: pelvic nodesN2: para-aortic nodes

Stages of Uterine Cancer Stage I (T1N0) Stage II (T2N0) Stage IIIa (T3aN0) Stage IIIb (T3bN0) Stage IIIC1 (T1-3N1) Stage IIIC2 (T1-3N2) Stage Iva (T4) Stage IVb (M1)

Uterine cancer can spread to lymph nodes

PET ScanSingle area ofmetastases inright para-aorticlymph nodesBiopsyconfirmedrecurrent cancer

Internal view (cross section) from PET

PET Scan = mets in para-aortic andpelvic nodes so stage IIIC endometrialcancer

Uterinecancer thathas spreadto para-aortic andpelvic nodesas seen onPET scan

5 Year Survival for Endometrial Cancer based on the Stage

5 Year Survival for Endometrial Cancer based on the histology of the cancer

Treatment of Endometrial Cancer For most stages surgery (hysterectomy, TAH-BSO- PPLND) is performed and postOp radiation is indicated for high risk features:•Deep muscle invasion (stage T1b)•Involvement of cervix (stage T2)•Spread to nodes, ovaries or tubes (Stage T3)•High risk pathology: high grade, vascular invasion, serousor clear cell

Adverse prognostic factors are used to stratify women with intermediate-risk endometrial cancer: •outer one-third myometrial invasion •grade 2 or 3 differentiation •lymphovascular invasion within the cancer.High-intermediate risk – This is based on a combination of age andnumber of prognostic factors present: •Patients of any age with all three factors •Patients 50 to 69 years old with two factors •Patients 70 years or older with only one factor

Guidelines for the use of radiation after a hysterectomy

Guidelines for the use of radiation after a hysterectomy

Dose Guidelines

CT scan is obtained at the time of simulation CT images are then imported into the treatment planning computer

In the simulationprocess the CTand PET scanimages are usedto create acomputer plan

In the treatmentthe lasers areused to line upthe beam and thepatient receivesthe radiationtreatment

Radiation for advanced uterine cancer totreat pelvis plus para-aortic lymph nodes

Tomotherapy for Advanced Uterine Cancer

Computer reconstruction of radiation fields tocover groin and pelvic lymph nodes but avoidthe bladder and rectum in vulva cancer patient

Combine a CT scan and linear accelerator to ultimate intargeting (IGRT) and ultimate in delivery (dynamic, helicalIMRT) ability to daily adjust the beam (ART or adaptiveradiotherapy)

Tomotherapy fields used to hit the groin andpelvic nodes but avoid the bladder andrectum

HDR = high dose rate machine that can runradiation through a tube that reaches thepatient through vaginal applicators

Internal radiation devices Procedure can be performed in hospital and the patient stays over night using a Cesium isotope applicator or the procedure can be done as an outpatient with a faster technique (called high dose rate or HDR) using an Iridium isotope source (Iridium 192 with half life of 74 days)

Vaginal cylinder isinserted into thevagina, the radiationtube or wire staysinside the tube anddoesn’t touch thepatient’s skin

A Wire or Tube connects the vaginal cylinderthe machine that holds the radioactive(Iridium) source

The woman lays on the radiation table and the treatmentusually takes about 5 minutes and then the cylinder isremoved

PostOp radiation for endometrial cancer isgenerally vaginal vault cylinder with HDR

Very little radiation reaches the bladder orrectum

Side Effects of Pelvic Radiation






Side Effects of Vaginal Cylinder HDR Radiation •Vaginal irritation or discharge •Bladder irritation or frequency •Bowels more frequent, soft or mild rectal irritation

Cancer of the Uterus or Endometrium Robert Miller MD www.aboutcancer.com

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