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Urinary 6-sulfatoxymelatonin in episodic and chronic migraine

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Information about Urinary 6-sulfatoxymelatonin in episodic and chronic migraine
Health & Medicine

Published on March 16, 2009

Author: enxaqueca

Source: slideshare.net

Description

Urinary 6-sulfatoxymelatonin in episodic and chronic migraine
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Urinary 6-sulfatoxymelatonin in episodic and chronic migraine Mario F.P.Peres (1), Marcelo R Masruha (1,2), Eliova Zukerman (1), Savio Vieira (1,2), Jose Cipolla-Neto (3) 1. IIEP- Albert Einstein, Sao Paulo, SP, Brazil. 2. EPM, UNIFESP, Sao Paulo, SP, Brazil. 3. ICB, USP, Sao Paulo, SP, Brazil. Background : Altered melatonin levels have been found in cluster headache and migraine with and without aura, menstrual migraine and chronic migraine. Episodic and chronic migraine melatonin levels have never been compared. Nocturnal plasma melatonin profile has been shown good correlation with urinary nocturnal 6-sulfatoxymelatonin levels. Patients and Methods : Forty-five patients were studied. Fifteen chronic migraine patients, 15 episodic migraineurs and 15 age-matched controls were enrolled. Nocturnal 12 hour (from 20:00 hs to 08:00 hs) urinary 6-sulfatoxymelatonin levels were analyzed in those patients by ELISA antibody technique. Headache diagnosis was done based on the International Classification for Headache Disorders, 2004. The study was approved by the local ethics committee. Results : Chronic migraine patients had signifficantly decreased 6-sulfatoxymelatonin levels when compared to episodic migraine patients and controls (p<0,01). Episodic migraine patients did not differ from controls. Conclusions : Our results support the role of melatonin secretion in the pathogenesis of chronic migraine. It is further evidence on the hypothalamic involvement in migraine. New emerging therapies targetting this system may be studied in migraine treatment.

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