Types of Bioreactors / Fermenters

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Information about Types of Bioreactors / Fermenters

Published on February 20, 2014

Author: ajithnandanam

Source: slideshare.net


The heart of the fermentation or bioprocess technology is the Fermentor or Bioreactor. A bioreactor is basically a device in which the organisms are cultivated to form the desired products. it is a containment system designed to give right environment for optimal growth and metabolic activity of the organism.
A fermentor usually refers to the containment system for the cultivation of prokaryotic cells, while a bioreactor grows the eukaryotic cells (mammalian, insect cells, etc).

Types of Bioreactor / Fermenter www.technologyinscience.blogspot.com Powerpoint Templates Page 1

Bioreactor / Fermenter A bioreactor is basically a device in which the organisms are cultivated to form the desired products. It is a containment system designed to give right environment for optimal growth and metabolic activity of the organism. Powerpoint Templates www.technologyinscience.blogspot.com Page 2

Bioreactor / Fermenter Powerpoint Templates Page 3

Types of Bioreactors • • • • • • • • Stirred Tank Bioreactor Airlift Bioreactor Packed Bed Bioreactor Fluidized Bed Bioreactor Photo Bioreactor Membrane Bioreactor Rotary Drum Bioreactor Mist Bioreactor Powerpoint Templates www.technologyinscience.blogspot.com Page 4

Stirred Tank Bioreactor Powerpoint Templates www.technologyinscience.blogspot.com Page 5

Advantages of Stirred Tank Bioreactor • • • • • • • Continuous operation. Good temperature control. Easily adapts to two phase runs. Good control. Simplicity of construction. Low operating cost. Easy to clean. Powerpoint Templates Page 6

Disadvantages of Stirred Tank Bioreactor • • The need for shaft seals and bearings. Size limitation by motor size, shaft length & weight. Powerpoint Templates www.technologyinscience.blogspot.com Page 7

Airlift Bioreactor Powerpoint Templates Page 8

Advantages of Airlift Fermenter • • • • • Simple design Easier sterilization (no agitator shaft parts) Low Energy requirement vs stirred tank Greater heat-removal vs stirred tank Very low cost Powerpoint Templates www.technologyinscience.blogspot.com Page 9

Disadvantages of Airlift Fermenter • Greater air throughput and higher pressures needed. • Inefficient break the foam when foaming occurs. • NO bubbles breaker Powerpoint Templates Page 10

Packed Bed Bioreactor Powerpoint Templates Page 11

Advantages of Packed Bed Reactor • Higher conversion per unit mass of catalyst than other catalytic reactors • Low operating cost • Continuous operation • No moving parts to wear out • Catalyst stays in the reactor • Reaction mixture/catalyst separation is easy • Effective at high temperatures and pressures Powerpoint Templates Page 12

Disadvantages of Packed Bed Reactor • • • • • Undesired heat gradients Poor temperature control Difficult to clean Difficult to replace catalyst Undesirable side reactions Powerpoint Templates Page 13

Fluidized Bed Bioreactor Powerpoint Templates Page 14

Advantages of Fluidized Bed Reactor • Uniform Particle Mixing: • Uniform Temperature Gradients • Ability to Operate Reactor in Continuous State Powerpoint Templates www.technologyinscience.blogspot.com Page 15

Disadvantages of Fluidized Bed Reactor • Increased Reactor Vessel Size • Pumping Requirements and Pressure Drop • Particle Entrainment • Lack of Current Understanding • Erosion of Internal Components • Pressure Loss Scenarios Powerpoint Templates www.technologyinscience.blogspot.com Page 16

Photo Bioreactor Powerpoint Templates Page 17

Advantages of Photobioreactor • • • • Higher productivity Large surface-to-volume ratio Better control of gas transfer. Reduction in evaporation of growth medium. • More uniform temperature. Powerpoint Templates www.technologyinscience.blogspot.com Page 18

Disadvantages of Photobioreactor • Capital cost is very high. • The productivity and production cost in some enclosed photobioreactor systems are not much better than those achievable in open-pond cultures. • The technical difficulty in sterilizing Powerpoint Templates www.technologyinscience.blogspot.com Page 19

Membrane Bioreactor Powerpoint Templates Page 20

Advantages of membrane bioreactor • The loss of enzyme is reduced. • Enzyme lost by denaturation can be made up by periodic addition of enzyme. • Substrate and enzyme can be easily replaced. Powerpoint Templates www.technologyinscience.blogspot.com Page 21

Rotary Drum Bioreactor Powerpoint Templates Page 22

Advantages of Rotary Drum Reactor • High oxygen transfer. • Good mixing facilitates better growth and impart less hydrodynamic stress. Powerpoint Templates www.technologyinscience.blogspot.com Page 23

Disadvantages of Rotary Drum Reactor • Difficult to scale up. Powerpoint Templates www.technologyinscience.blogspot.com Page 24

Mist Bioreactor Powerpoint Templates Page 25

Advantages of Mist Bioreactor • High oxygen transfer. • Hydrodynamic stress elimination. • Low production cost. Powerpoint Templates www.technologyinscience.blogspot.com Page 26

Disadvantages of Mist Bioreactor • Mesh trays and cylindrical stainless steel meshes are required Powerpoint Templates www.technologyinscience.blogspot.com Page 27

Click here to read more on Types of Biore www.technologyinscience.blogspot.com Powerpoint Templates Page 28

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