Theise Upaya 1 2008

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Information about Theise Upaya 1 2008

Published on January 23, 2008

Author: neiltheise

Source: slideshare.net

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Physiology of Yogic Practices

Science as Koan: Stem cells, complexity, and the science of Being All lands are in my body And so are the Buddhas living there; Watch my pores, And I will show you the Buddha’s realm.                                       Avatamsaka (Flower Ornament) Sutra Neil Theise MD Departments of Pathology & Medicine Beth Israel Medical Center – Albert Einstein College of Medicine New York City www.neiltheise.com

True Nature of Reality

Cognitive Contemplative True Nature of Reality

Cognitive Contemplative

Cognitive Contemplative Germs exist and cause disease

Cognitive Contemplative Germs exist and cause disease UV light leads to suntans and skin cancer

Cognitive Contemplative Germs exist and cause disease UV light leads to suntans and skin cancer Our galaxy is one of uncountable numbers in the universe…

Cognitive Contemplative

Cognitive Contemplative Physical Nature of Reality Spiritual Nature of Reality

Cognitive Contemplative Physical Nature of Reality Spiritual Nature of Reality 1998

 

 

Lethal Irradiation Male bone marrow transplant F.I.S.H. for Y-Chromosome

 

The Standard Paradigm: Restricted Plasticity

Irreversible gene restrictions Embryology & Adult Tissue Reconstitution Self renewal

BEWARE OF DOGMA

The Great Stem Cell Debate 2001

Embryonic Stem Cells All three layers of the embryo: Mesoderm, Endoderm, Ectoderm

Embryonic Stem Cells All three layers of the embryo: Mesoderm: muscle, blood, bone Endoderm: visceral organs Ectoderm: brain, nerves, skin so….

Embryonic Stem Cells Can make everything!

Embryonic Stem Cells Can make everything, in order to: perform cell transplants… create artificial organs (livers!) implant genes for gene therapies…

Embryonic Stem Cells Can make everything! Adult Stem Cells Can make . . . ?

Sort PKH-bright Male Donor BM Lin Deplete Elutriate PKH26 Label 48 Hours Transplant single cell into 2 o Female Recipient 1 o Female Recipient

Lin Deplete

Elutriate

 

 

 

 

 

 

 

Bone Marrow One Adult Cell Epithelia of Liver Lung Gut, (Pancreas) Skin, Hair follicles

Epithelia of

Liver

Lung

Gut, (Pancreas)

MESODERM True clonality = True adult stem cell plasticity! One Adult Cell ENDODERM ECTODERM

Pause

 

What if gene restrictions are REVERSIBLE?

 

Proof of Principle

3 Principles of Plasticity Theise & Krause BCMD , May 2001 Leukemia, April Fool’s Day 2002 Comptes Rendus Biologies, December 2002

1. Genomic Completeness 2. Cellular Uncertainty 3. Stochasticity of Cell Origins and Fates

1. Genomic Completeness 2. Cellular Uncertainty 3. Stochasticity of Cell Origins and Fates

“… the internal and the external co-determine the cell.” Richard Lewontin, 2000

2 nd Principle: Cellular Uncertainty Any attempt to observe a cell alters the state of that cell at the time of characterization and potentially alters the likelihood of subsequent differentiation events.

2 nd Principle: Cellular Uncertainty Any attempt to observe a cell alters the state of that cell at the time of characterization and potentially alters the likelihood of subsequent differentiation events. ?

Meanwhile, back at the plasticity debates…

Controversy!!!

trivial... vs. ROBUST!!!

Conversations with Jane Prophet New Media Artist and Professor, Interdisciplinary Studies University of Westminster, London UK SciArt Award, Wellcome Trust 2002

Date: 9th May 2002 Location: Neil's office, New York    Jane says: “Ideas about pathways are interesting. A lot of people who are involved in digital biology are interested in things like swarming people and so called ’soup organism’ behaviour. And one of the useful models to take forward is about ant colonies…”

Complex Adaptive Systems: 1,2 1 Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002. 2 Johnson S, Emergence. New York NY: Scribner; 2001.

Complex Adaptive Systems: Interacting individuals that, fulfilling 4 criteria, organize themselves from the bottom up, into larger structures…

Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures, which appear planned from the top, downward…

Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures, which appear planned from the top, downward, BUT ARE NOT!

Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures which appear planned from the top, downward, BUT ARE NOT! These structures are referred to as “ emergent self-organization” and are ADAPTIVE.

Complex Adaptive Systems: Rise and fall of economic markets Urban development Immune systems Beatlemania Rise and fall of civilizations Evolution and speciation

Complex Adaptive Systems: Rise and fall of economic markets Urban development Immune systems Beatlemania Rise and fall of civilizations Evolution and speciation Conciousness

Complex Adaptive Systems: Rise and fall of economic markets Urban development Immune systems Beatlemania Rise and fall of civilizations Evolution and speciation Conciousness Sesshin!

Complex Adaptive Systems: Numbers matter

Complex Adaptive Systems:

Numbers matter

Complex Adaptive Systems: Numbers matter Negative feedback loops

Complex Adaptive Systems:

Numbers matter

Negative feedback loops

Complex Adaptive Systems: Numbers matter Negative feedback loops Interactions are local without global sensing

Complex Adaptive Systems:

Numbers matter

Negative feedback loops

Interactions are local without global sensing

Complex Adaptive Systems: Numbers matter Negative feedback loops Interactions are local without global sensing Low level randomness

Complex Adaptive Systems:

Numbers matter

Negative feedback loops

Interactions are local without global sensing

Low level randomness

Complex Adaptive Systems: Numbers matter Negative feedback loops Interactions are local without global sensing “ Quenched disorder”

Complex Adaptive Systems:

Numbers matter

Negative feedback loops

Interactions are local without global sensing

“ Quenched disorder”

 

 

 

Low level engraftment is not only NOT trivial, but it is VITAL – literally so. 1-3 1 Theise ND. Exp Hematology 2003 2 D’Inverno M, Theise ND. BCMD 2004 3 D’Inverno M, Theise ND, Prophet J. In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications

Pause

Implications of Cell Lineages as Complex Adaptive Systems Mass extinctions.

order disorder “ chaos”

disorder “ chaos” complex adaptive systems order

Implications of Cell Lineages as Complex Adaptive Systems Mass extinctions, eg: ? Aplastic anemia ? Fulminant liver failure

Implications of Cell Lineages as Complex Adaptive Systems The price of adaptation, i.e. of LIFE, is DEATH

Implications of Cell Lineages as Complex Adaptive Systems Hierarchies of complex systems…

 

 

 

Implications of Cell Lineages as Complex Adaptive Systems Hierarchies of complex systems… thing vs. phenomena depends on scale of observation

Communities Bodies Cells

e.g. cities, cultures, ecosystems, Gaia Bodies Cells

Communities Bodies Cells Biomolecules ?

Communities Bodies Cells ?

Communities Bodies Cells Biomolecules

Communities Bodies Cells Biomolecules More implications, of course.

1. Genomic Completeness ? Cellular Uncertainty 3. Stochasticity of Cell Origins and Fates

Theise ND. Now you see it, now you don’t. Nature , May 2005 “ Cell doctrine: modern biology and medicine see the cell as the fundamental building block of living organisms, but this concept breaks down at different perspectives and scales.” Communities Bodies Cells Biomolecules

“ The validity of cell doctrine depends on the scale at which the body is observed… Communities Bodies Cells Biomolecules

“ The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology… Communities Bodies Cells Biomolecules

“ The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology… e.g. Acupuncture Communities Bodies Cells Biomolecules

“ The validity of cell doctrine depends on the scale at which the body is observed. To limit ourselves to the perspective of this model may mean that explications of some bodily phenomena remain outside the capacity of modern biology. It is perhaps time to dethrone the doctrine of the cell, to allow alternative models of the body for study and exploitation in this new, postmodern era of biological investigation.” Communities Bodies Cells Biomolecules

What kind of models?

for example, 2 models from Ancient Greece: Is the body made of… indivisible subunits or an endlessly divisible fluid

 

 

 

 

Models of the body are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid

Models are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid Yet another way (the genome): … overlapping spatial/temporal fields of molecular organization

Pause

Still more implications of complexity in life…

Communities Bodies Cells Biomolecules Atoms

Communities Bodies Cells Biomolecules Atoms Subatomic Particles

Communities Bodies Cells Biomolecules Atoms Subatomic Particles Strings (or whatever)

Communities Bodies Cells Biomolecules Atoms Subatomic Particles Strings (or whatever) The Quantum Foam

We don’t live in the universe . . .

. . . we are the universe

The Relative

The Absolute

Implications of Everything as Complex Adaptive System “ thingness” is dependent on scale

Implications of Everything

as Complex Adaptive System

“ thingness” is dependent on scale

Implications of Everything as Complex Adaptive System Emptiness of inherent existence

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Inevitable mass extinction

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Inevitable mass extinction

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Impermanence

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Impermanence

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Impermanence 3. Systems depend on EVERY member

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Impermanence

3. Systems depend on EVERY member

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Impermanence 3. Interdependence

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Impermanence

3. Interdependence

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Impermanence 3. Interdependence 4. The fact of emergence is predictable, the nature of it is not.

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Impermanence

3. Interdependence

4. The fact of emergence is predictable,

the nature of it is not.

Implications of Everything as Complex Adaptive System Emptiness of inherent existence 2. Impermanence 3. Interdependence 4. Karmic law (cause and effect)

Implications of Everything

as Complex Adaptive System

Emptiness of inherent existence

2. Impermanence

3. Interdependence

4. Karmic law (cause and effect)

Implications of Everything as Complex Adaptive System Buddhist Metaphysics

Pause

Cognitive Contemplative 1998

Cognitive Contemplative

Cognitive Contemplative One True Nature of Reality, Not Two…

Diane Krause MD PhD Saul Sharkis MD PhD, Michael Collector Octavian Henegariu MD Sonya Hwang MD, Rebekah Gardner Sarah Neutzel Single cell multiorgan plasticity

Cell Team Jane Prophet Mark D’Inverno Rob Saunders Peter Ride Neil Theise Discussions were part of the production of "Cell", a collaboration across art and science funded by a Wellcome Trust SciArt Award and an award from Future Physical. "Cell" is coordinated by Peter Ride and is a DA2 Digital Arts Agency production.

my Zen teacher, Roshi Pat Enkyo O’hara and of course …

 

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