The Potential Application Of Stem Cells For Rejuvenation

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Information about The Potential Application Of Stem Cells For Rejuvenation
Health & Medicine

Published on January 29, 2009

Author: nofa999

Source: slideshare.net

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Presented by dr Boenjamin Setiawan, PhD.

The Potential Application of Stem Cells for Rejuvenation Dr Boenjamin Setiawan,Ph.D.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

What can we do about it ? Change of life style and regular exercise Caloric Restriction Adequate Nutrition Antioxidant supplementation Hormone replacement therapy, Growth Hormone, Testosterone, Progesterone, Estrogen Stem Cell Therapy Genetic engineering

Change of life style and regular exercise

Caloric Restriction Adequate Nutrition

Antioxidant supplementation

Hormone replacement therapy, Growth Hormone, Testosterone, Progesterone, Estrogen

Stem Cell Therapy

Genetic engineering

Aging begins with the union of sperm and egg Aging is a continuous process beginning at the union of the sperm and the egg. The zygote, of course, is the ultimate stem cell with unlimited developmental potency or plasticity. Development in complex multicellular organisms is all about the compartmentalization and specialization of physiological functions into organ systems. With it goes compartmentalization of stem cells that to various degrees retain some multipotency . Source: Gary Van Zant and Ying Liang; The role of stem cells in aging; Experimental Hematology 31 (2003) 659-672

Aging is a continuous process beginning at the union of the sperm and the egg. The zygote, of course, is the ultimate stem cell with unlimited developmental potency or plasticity. Development in complex multicellular organisms is all about the compartmentalization and specialization of physiological functions into organ systems. With it goes compartmentalization of stem cells that to various degrees retain some multipotency .

Stem Cells for Rejuvenation Stem Cells Seen As Crucial For Rejuvenation And Life Extension The idea that stem cells will be used to rejuvenate aged bodies shows signs of becoming the conventional wisdom among stem cell researchers. Writing in the journal EMRO reports of the European Molecular Biology Organization two recent articles address this prospect. First, researcher Nadia Rosenthal examines "Youthful prospects for human stem-cell therapy" for both disease prevention and life extension

Stem Cells Seen As Crucial For Rejuvenation And Life Extension The idea that stem cells will be used to rejuvenate aged bodies shows signs of becoming the conventional wisdom among stem cell researchers. Writing in the journal EMRO reports of the European Molecular Biology Organization two recent articles address this prospect. First, researcher Nadia Rosenthal examines "Youthful prospects for human stem-cell therapy" for both disease prevention and life extension

Stem Cells can Rejuvenate Aged Body Organs Rosenthal foresees a future in which stem cell-based therapies rejuvenate aged parts of the body and allow much longer lifespans . Stem cell research seems inevitably to lead to such thoughts. Stem cell researchers want to develop youthful, genetically undamaged, and flexible stem cells. Once they accomplish this for a wide range of stem cell types it is hard to avoid the conclusion that many parts of the body could be repaired by sending in youthful cells to gradually replace the old cells.

Rosenthal foresees a future in which stem cell-based therapies rejuvenate aged parts of the body and allow much longer lifespans . Stem cell research seems inevitably to lead to such thoughts. Stem cell researchers want to develop youthful, genetically undamaged, and flexible stem cells. Once they accomplish this for a wide range of stem cell types it is hard to avoid the conclusion that many parts of the body could be repaired by sending in youthful cells to gradually replace the old cells.

The Age of Stem Cells determines the Regenerative Potential Hence, all ageing phenomena—tissue deterioration, cancer and propensity to infections—can be interpreted as signs of ageing at the level of somatic stem cells. As the regenerative prowess of a living organism is determined by the ability and potential of its stem cells to replace damaged tissue or worn-out cells, a living organism is therefore as old as its stem cells.

Hence, all ageing phenomena—tissue deterioration, cancer and propensity to infections—can be interpreted as signs of ageing at the level of somatic stem cells. As the regenerative prowess of a living organism is determined by the ability and potential of its stem cells to replace damaged tissue or worn-out cells, a living organism is therefore as old as its stem cells.

Age determines the clinical outcome of BM transplantation age represents the main variable and worst prognostic factor for clinical outcome of transplantation . Recent evidence indicates that there is a decline with age in the quantity and quality of the CD34+ cells harvested. There is also a change in the ratio of fat to cellular bone marrow with age, which has been well known since the turn of the twentieth century

age represents the main variable and worst prognostic factor for clinical outcome of transplantation . Recent evidence indicates that there is a decline with age in the quantity and quality of the CD34+ cells harvested. There is also a change in the ratio of fat to cellular bone marrow with age, which has been well known since the turn of the twentieth century

Stem Cells determine the lifespan of mammals The objectives of this review were first to critically review what is known about the effects of aging on stem cells in general, and hematopoietic stem cells in particular. Secondly, evidence is marshalled in support of the hypothesis that aging stem cells play a critical role in determining the effects of aging on organ function, and ultimately on the lifespan of a mammal . Aging has both quantitative and qualitative effects on stem cells. On balance, the qualitative changes are the more important since they affect the self-renewal potential, developmental potential, and interactions with extrinsic signals, including those from stroma .                   The role of stem cells in aging. Experimental hematology,2003 Aug.31(8), 659-72 Van Zant G , Liang Y .

The objectives of this review were first to critically review what is known about the effects of aging on stem cells in general, and hematopoietic stem cells in particular. Secondly, evidence is marshalled in support of the hypothesis that aging stem cells play a critical role in determining the effects of aging on organ function, and ultimately on the lifespan of a mammal . Aging has both quantitative and qualitative effects on stem cells. On balance, the qualitative changes are the more important since they affect the self-renewal potential, developmental potential, and interactions with extrinsic signals, including those from stroma .

                  The role of stem cells in aging. Experimental hematology,2003 Aug.31(8), 659-72 Van Zant G , Liang Y .

FIGURE 1. Tissue heterogeneity and stem-cell functionality for homeostasis and repair

FIGURE 2. Variation of maximal lifespan across species. From the following article: Stem cells, ageing and the quest for immortality Thomas A. Rando Nature 441, 1080-1086 (29 June 2006) doi:10.1038/nature04958

Stem cells, ageing and the quest for immortality Thomas A. Rando Influence on Stem Cell Functionality

FIGURE 4. Ageing of stem-cell functionality

The Decline of Stem Cell Functionality The decline in stem-cell functionality with age can be due to age-related changes at many levels. This figure illustrates several possibilities using a skeletal muscle fibre and an associated stem (satellite) cell as a model. In response to tissue injury, local signals induce satellite cells to begin proliferating in order to generate sufficient progeny for tissue repair. Age-related changes in satellite cells, in the satellite-cell niche or in the systemic milieu could all result in a diminished functionality of satellite cells in an aged organism, manifested as a decreased propensity to generate sufficient functional progeny for effective regeneration.

The decline in stem-cell functionality with age can be due to age-related changes at many levels. This figure illustrates several possibilities using a skeletal muscle fibre and an associated stem (satellite) cell as a model. In response to tissue injury, local signals induce satellite cells to begin proliferating in order to generate sufficient progeny for tissue repair. Age-related changes in satellite cells, in the satellite-cell niche or in the systemic milieu could all result in a diminished functionality of satellite cells in an aged organism, manifested as a decreased propensity to generate sufficient functional progeny for effective regeneration.

Chronological and replicative ageing.

Bone Marrow or UCB stem cells will rejuvenate the body The use of hESC still creates many controversies The use of adult stem cells derived from UCB is a very acceptable alternative hUCB can be expanded many times The immunogenicity of hUCB is low when still undifferentiated hUCB can be given for regenerative purposes, such as AMI, stroke, osteoarthritis etc. Organ regeneration will result in REJUVENATION

The use of hESC still creates many controversies

The use of adult stem cells derived from UCB is a very acceptable alternative

hUCB can be expanded many times

The immunogenicity of hUCB is low when still undifferentiated

hUCB can be given for regenerative purposes, such as AMI, stroke, osteoarthritis etc.

Organ regeneration will result in REJUVENATION

TERIMA KASIH

TERIMA

KASIH

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