The neurobiology of spontaneous actions and operant learning in Drosophila

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Information about The neurobiology of spontaneous actions and operant learning in Drosophila

Published on March 5, 2009

Author: brembs

Source: slideshare.net

Description

Learning about the consequences of our actions (operant learning) is one of the major ways in which we learn to understand the world we live in. Despite our recent advances in the neurobiology of learning and memory, this “learning-by-doing” has largely withstood neurobiological scrutiny. This proposal aims to elucidate the molecular and neurobiological mechanisms of spontaneous behavioral choice and how decision-making is modulated by the consequences of such actions. This research will be done in a genetically amenable model system, the fruit fly Drosophila. We will use state-of-the-art genetic and behavioral techniques to identify the circuitry and molecular processes involved in generating spontaneous turning behavior and its modulation by operant learning. Operant learning is only one system among many which govern the organization of behavior. The long-term prospect of this research beyond this application is to understand how multiple memory systems interact to accomplish adaptive behavioral choice and decision-making.

Björn Brembs Freie Universität Berlin

08.06.09 Björn Brembs, Freie Universität Berlin Prerequisites Spontaneous behavior Functions Learning about the environment (lever) Learning about the consequences of one‘s own behavior (pressing) Distinguishing between exafferent and reafferent stimuli (self vs. non-self) Control over environment Consequences Memories Agency Habits

Prerequisites

Spontaneous behavior

Functions

Learning about the environment (lever)

Learning about the consequences of one‘s own behavior (pressing)

Distinguishing between exafferent and reafferent stimuli (self vs. non-self)

Control over environment

Consequences

Memories

Agency

Habits

08.06.09 Björn Brembs, Freie Universität Berlin Basic research: Adaptive behavioral choice requires knowledge of the consequences of one‘s own behavior Human disorders associated with various operant processes: Habit formation a model for addiction, OCD High comorbidity among disorders, e.g., Anorexia/OCD, self-harming/dissociative disorders Disorder Operant aspect Autism spectrum, depression, OCD, ADHD, Tourette, Parkinson Spontaneous behavioral variability, action initiation Depression („learned helplessness“), Anorexia nervosa Control over environment Self-harming patients, dissociative disorders Sense of self/agency

Basic research: Adaptive behavioral choice requires knowledge of the consequences of one‘s own behavior

Human disorders associated with various operant processes:

Habit formation a model for addiction, OCD

High comorbidity among disorders, e.g., Anorexia/OCD, self-harming/dissociative disorders

Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin

Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Evolutionary conservation Technical advantages

Basic research: how do different brains solve the problem of adaptive behavioral choice? 08.06.09 Björn Brembs, Freie Universität Berlin Classical/Pavlovian conditioning (fact-learning): Operant learning (skill-learning): Evolutionary conservation Technical advantages ? ? ?

The neurobiology of spontaneous behavior (PhD student) Localizing an operant memory (Postdoc: Dr. Julien Colomb) Identifying further molecular components of the operant learning system (Dr. Björn Brembs) 08.06.09 Björn Brembs, Freie Universität Berlin

The neurobiology of spontaneous behavior (PhD student)

Localizing an operant memory (Postdoc: Dr. Julien Colomb)

Identifying further molecular components of the operant learning system (Dr. Björn Brembs)

08.06.09 Björn Brembs, Freie Universität Berlin

08.06.09 Björn Brembs, Freie Universität Berlin

08.06.09 Björn Brembs, Freie Universität Berlin

PhD student 08.06.09 Björn Brembs, Freie Universität Berlin

PhD student

08.06.09 Björn Brembs, Freie Universität Berlin Maye et al. (2007) PLoS One Nonlinear (choice) Linear/stochastic (noise) Mushroom bodies Ellipsoid body Fan-shaped body nonlinearity correlation

PhD student 08.06.09 Björn Brembs, Freie Universität Berlin

PhD student

Dr. Julien Colomb 08.06.09 Björn Brembs, Freie Universität Berlin

Dr. Julien Colomb

08.06.09 Björn Brembs, Freie Universität Berlin operant classical

08.06.09 Björn Brembs, Freie Universität Berlin Brembs & Plendl (2008) Current Biology rut -AC dependent Synaptic Plasticity Protein Kinase C Required Required Not required Not required classical operant

Dr. Julien Colomb 08.06.09 Björn Brembs, Freie Universität Berlin

Dr. Julien Colomb

Dr. Björn Brembs 08.06.09 Björn Brembs, Freie Universität Berlin

Dr. Björn Brembs

Aplysia californica 08.06.09 Björn Brembs, Freie Universität Berlin F. Lorenzetti, D. Baxter, J. Byrne (2008): Neuron 59, 815-828

Aplysia californica

08.06.09 Björn Brembs, Freie Universität Berlin Collaboration with Dr. Zars (Missouri): P-Element in the last Exon of FoxP FoxP Required Not required PKC Required Not required

08.06.09 Björn Brembs, Freie Universität Berlin Synaptic plasticity: Operant learning ( Aplysia : neuronal plasticity?): ? ? ?

08.06.09 Björn Brembs, Freie Universität Berlin Brembs, Curr. Biol. In revis. Reciprocal, hierarchical interactions: Facilitate classical learning (learning-by-doing) Enable generalization of classical memories Regulate habit formation

Reciprocal, hierarchical interactions:

Facilitate classical learning (learning-by-doing)

Enable generalization of classical memories

Regulate habit formation

08.06.09 Björn Brembs, Freie Universität Berlin Brembs, Curr. Biol. In revis. Reciprocal, hierarchical interactions: Facilitate classical learning (learning-by-doing) Enable generalization of classical memories Regulate habit formation Operant learning (habit formation): Habit-formation is a model for addiction, OCD, stereotypies Operant Behavior (detection of control): Sense of control over environment affected in depression („learned helplessness“), anorexia nervosa Sense of self/agency altered in self-harming patients, dissociative disorders

Reciprocal, hierarchical interactions:

Facilitate classical learning (learning-by-doing)

Enable generalization of classical memories

Regulate habit formation

Operant learning (habit formation):

Habit-formation is a model for addiction, OCD, stereotypies

Operant Behavior (detection of control):

Sense of control over environment affected in depression („learned helplessness“), anorexia nervosa

Sense of self/agency altered in self-harming patients, dissociative disorders

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