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STEROIDS

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Information about STEROIDS
Education

Published on June 18, 2007

Author: WoodRock

Source: authorstream.com

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© Univ. Prof. Dr. Kurt R. Herkner (2006):  © Univ. Prof. Dr. Kurt R. Herkner (2006) Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide2:  Univ. Prof. Dr. Kurt R. Herkner Univ. Klinik f. Kinder- u. Jugendheilkunde Medizinische Universität, Wien Hauptlabor Autoimmunologisches Labor Inst. zur Erforschung des kindlichen Rheumas Biology of Steroid Hormones STEROIDS:  STEROIDS plant – animal – human – synthetic - Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas GONAN (Cyclopentano-Perhydrophenantren):  GONAN (Cyclopentano-Perhydrophenantren) Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide5:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Pflanzliche und tierische Steroide:  Pflanzliche und tierische Steroide Zoosterine: z.B. CHOL, Koprostanol Phytosterine: Vitamin D (Calciferol, Cholecalciferol) Gallensäuren Sapogenine Herzglykoside (Cardenolide) z.B. Digitoxi(geni)n Steroidalkaloide (N-haltige Steroide, als Ester o. Glykoside) Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Steroids:  Steroids H O R M O N E S Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide8:  Steroid Hormon Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide9:  SYNTHESIS Acetyl Co-A -andgt; Terpenes -andgt; Cholesterol -andgt; (Steroid-) Hormon andamp; ONTOGENESIS (human) Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide10:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide11:  Analytics Index Effects Synthesis Metabolism (general) Utilisation andamp; -andgt; Metabolism Molecular andamp; Cellular Mechanisms Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas (most common) Analytics …:  (most common) Analytics … Gas Chromatography Radio Gas Chromatography Gas Chromatography – Mass Spectrometry Radio Immuno-Assay (Enzyme Immuno-Assay) (HPLC) Receptor Assay Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide13:  17 C Gonan (Steran) 18 C ESTROGENS Estrane-Derivatives 19 C ANDROGENS Androstan–Derivatives andamp; (1,4) Androsten – 21 C GESTAGENS CORTICOIDS Pregnan–Derivatives andamp; (1,4) Pregnen – Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide14:  (20,22-) Desmolase Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Gestagene(Gelbkörperhormone):  Gestagene (Gelbkörperhormone) Verhindern den Eisprung und bereiten das Endometrium vor. Progesteron Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide16:  17 C Gonan (Steran) 18 C ESTROGENS Estrane-Derivatives 19 C ANDROGENS Androstan–Derivatives andamp; (1,4) Androsten – 21 C GESTAGENS CORTICOIDS Pregnan–Derivatives andamp; (1,4) Pregnen – Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide17:  (20,22-) Desmolase Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas TESTOSTERONE(17ß-Hydroxy-4androsten-3-on):  TESTOSTERONE (17ß-Hydroxy-4androsten-3-on) DIHYDROTESTOSTERONE(17ß-Hydroxy-5&-androstan-3-on):  DIHYDROTESTOSTERONE (17ß-Hydroxy-5andamp;-androstan-3-on) Slide20:  17 C Gonan (Steran) 18 C Estradiol - 19 C Androstan – (1,4) Androsten – 21 C Pregnan – (1,4) Pregnen – Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide21:  (20,22-) Desmolase Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide22:  … Pathways of Synthesis (Enzymes of Synthesis) … Pathways of Metabolism =andgt; (Degradation Enyzmes) =andgt; Molecular andamp; Cellular Mechanisms (Intracellular Enzymes) Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide23:  The mechanism of action of steroid [hormones] by the example of ANDROGENS Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide24:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide25:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide26:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide27:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas The androgen / steroid hormone action can best characterised by the principle of utilisation+turn over and excretion (with or without) hormone metabolism.#Androgens are capable of metabolites possesing still hormone activity:  The androgen / steroid hormone action can best characterised by the principle of utilisation+turn over and excretion (with or without) hormone metabolism. # Androgens are capable of metabolites possesing still hormone activity Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide29:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide30:  Univ.Prof.Dr.Kurt R. Herkner Institut zur Erforschung des kindlichen Rheumas Slide31: 

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