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Information about SoS

Published on March 25, 2008

Author: funnyside


Slide1:  ©2005 The President and Fellows of Harvard College Slide2:  If my calendar is correct, this is 2005 and this is my eighth State of the School address. This fall, as every other fall, has been associated with many new things happening and I can assure you that this is not a dull place. There are five areas that I would note at the beginning of my comments and I will allude to in various parts of the presentation. The first area is some administrative changes that we have had within the medical school itself. The second is new plans for education reform and reorganization of the Program in Medical Education staff, new opportunities with our teaching hospitals, new challenges in our relationships to the university, particularly with respect to the Allston planning, and new developments in our global activities. Slide3:  Those who create value through leadership, relationships, and creativity will transform their field. This spring I enjoyed very much the reading of Thomas Friedman’s book, The World Is Flat. As those of you who read The New York Times know, he is one of the distinguished Op-Ed writers. He is a foreign affairs columnist for the Times and his premise in writing this book is that we live in a very different world as a result of globalization, the convergence of new technologies, and dramatic changes in the political and economic landscape. As a result of these, competition is no longer based on who can get the job done or even who is willing to do it the cheapest. The fall of the Berlin Wall; change in economic policies in Asia; Netscape; Google; massive overcapacity, continued Slide4:  particularly in our fiber optic systems; and collaboration enhancing software have created a very different world where high-quality work is being done essentially everywhere. The flattening then, in my own interpretation of his work, has had a profound impact on the way we conduct our international business affairs. Outsourcing, in-sourcing, the juggling of trade deficits, and offshore economic arrangements have each resulted in new constructs in the relationships between business, government, and educational entities throughout the world. I like the one example that he gave about Dell Computer, which is currently the world’s largest computer company, to illustrate his principle. Dell sells between 140,000 and 150,000 computers each day, and the success of the company depends on worldwide transactions and delivery routes, but there is more to it than that. Research teams in Texas and Taiwan collaborate instantaneously on the design of new products and modifications of existing products. Ten countries, notably China, Malaysia, Korea, Japan, and Taiwan, produce the individual components. Product quotas, production quotas, quality control, and on-time delivery with virtually no inventories are characteristic of the business model. Our World Is Flattening:  Our World Is Flattening I would suggest that in a similar way, our world here at Harvard Medical School is also flattening. We have watched major changes over the past few years involving the entire medical community. Complexity is a way of life here. We have what I would refer to, and will come back to, as a nodal network of engagement with each other throughout our Harvard medical world. If you ask what the nature of the structure within which we operate is like, we don’t have a hub-and-spoke model. There is no single center with spokes that connect to it. There isn’t a hierarchical top-down continued Slide6:  arrangement to our activities. In fact, I am not sure that anybody is in charge. What we, in fact, have is, to come back to my own professional neuroscience neurology background, is a neural network of nodes that intersect and interact with each other and to a large degree are self-organizing in their activities based primarily on the brilliance of our faculty and the innovation of our faculty, the creativity of our staff, and the way they facilitate these connections and, of course, the students, who in the end really are the ones who create the innovation in our education and scientific world. Harvard Medical Network:  Harvard Medical Network Investing in IT Collaborating Locally Collaborating Globally Keeping the nodes humming So, in thinking about the interconnectivities and the activities that produce this kind of a world in which we live, I would like to, in the course of my presentation, cover these four topics: investing in information technology, collaborating locally, collaborating globally, and what I refer to as keeping the nodes humming. Investing in IT:  Investing in IT Fiber, servers, and . . . eCommons Countway renovations MyCourses New Center for Biomedical Informatics If we begin with the investment in IT, those of you who were here eight years ago know that we set about in a very definitive way to identify resources and to plug them into developing the information technology network that we needed. It has resulted in fibers and servers being placed all over our campus. It has resulted in the developing of eCommons. It was added to by the Countway renovations, the development of MyCourses, and a new center that I will tell you about for biomedical informatics. John Halamka, who has been the key to much of this, our chief information officer, says that Harvard Medical School now hosts a high-performance research cluster of over 150 CPUs and five trillion bytes, that is, five terabytes of storage serving the needs of our bioinformatics community. HMS now provides gigabyte networking speeds with secure, relatively virus-free data flowing over 18,000 different computers and printers. Harvard Medical School now provides over 25 terabytes, that is, 25 trillion bytes of storage for education content, department databases, and administrative records. And let me pause and thank all of you who staff these various components of our networking world and make possible the fact that I can instantaneously, when I arrive at nine in the morning, turn to Lorraine Caristo and say, "I want to get an email out to 14,000 people and have it done within a half-hour." Slide9:  This screen catch is an example of the use of eCommons, which allows one to essentially access everything inside and outside of our community with a single-entry ID and a single password. This happens to be an example of an international pilot study of the onset of schizophrenia. It is an international, multi-site pilot study looking at psychotic illness and factors that influence the delay in seeking care. Byron Good of our Department of Social Medicine works in this area with Eric Chin, who is a professor of psychiatry in Hong Kong. You can find out about these kinds of projects and the interactions of our faculty with projects of this sort instantaneously by accessing eCommons. Countway Renovation:  Countway Renovation 800 journals on line Network access added to all seating area This is a picture showing the major change that we all looked to as we entered the Countway Library—the new round staircase, from the first floor to the second floor. But the more important investment was the relatively minor cost of putting network wiring throughout this entire space. It allowed for wireless to be introduced to the entire library subsequently. And all of this has led to an interesting phenomenon, which is that the library is more empty than it used to be because you can access everything in our library from your own computer anywhere in the world. Slide11:  The other development which I think has really led the way in our educational activities is the development of MyCourses. MyCourses is currently accessed by students, staff, and faculty 18,000 times a day. It provides the content that makes possible the integration of ideas about a new course, or a new a diagram, or a physiological motion picture of how the heart or lungs or brain works in a way that continued Slide12:  permits all who wish to use it to access it and plug it into their particular course or function. We just this week will complete the second-year CNS course, which I have helped David Cordoza in doing this year. The second-year students have participated in something called Icon, which is an interactive, case-based, online network, which presents a case. This was done as part of the upgrading of our tutorial method of problem-based learning. This is a real doctor and a real patient. Names, of course, are kept confidential. And the students are required to be essentially on call, live, to participate in the care of the patient. So, a student may be paged at two in the morning, pick up the page, listen: "Your patient has just arrived in the emergency room. What would you like to do?" And the students have really loved it. They have felt engaged and involved. Jim Quattrochi, who is one of our tutors and has been for many years, is the key person behind this activity. Center for Biomedical Informatics:  Center for Biomedical Informatics The library will also now become part of a Harvard Medical School-wide center for biomedical informatics. Jules Dienstag, our dean of Medical Education, chaired a committee which searched for new leadership that would not only incorporate the standard functions of a library, but also introduce the new world of bioinformatics. As a result of this, we have an extraordinary team who have been appointed, which was announced just a few weeks ago. Isaac, or Zak, Kohane is the Henderson Associate Professor of Pediatrics at Children’s Hospital Boston and within our Health Sciences Technology division, and you might be surprised, or you won’t be surprised, but I should tell you that he is also a research affiliate of the MIT lab of computer science where he engages in some of the most intellectually challenging activities in the world of computers and bioinformatics. He is joined by Alexa McCray, who was recruited from the National Library of Medicine in Bethesda. She was formerly head of the Lister Hill National Center for Biomedical Communication and was the head of the research division at the National Library of Medicine, and the two of them have agreed in their coming together to create for us what I think will be a living laboratory unexcelled or unequaled anywhere else. Collaborating Locally:  Collaborating Locally MD education Graduate degree education Science education pipeline Research across disciplines Research across institutions So, let me turn to some of the collaborations locally. I want to cover medical education reform and some of the changes in the Program in Medical Education, some changes in the graduate degree education program, science education pipeline, research across disciplines, and research across institutions. Medical Education Reform MER Design Groups:  Medical Education Reform MER Design Groups Introduction to the Profession Fundamentals of Medicine In-depth Educational Experience Principal Clinical Experience Advanced Experiences in Clinical Medicine and Science Begins with class entering in 2006 So, let me begin with a project that has now been underway for four years. George Thibault, who is with us today, and Phil Leder took the self-study results of our LCME Review, which is an obligatory process we go through every seven or eight years, and together chaired a task force which came up with a series of recommendations, which subsequently led to a series of actions, and now to a period of implementation. Jules Dienstag, who assumed the full responsibilities as dean of Medical Education in May, has been, with George’s help and my engagement and involvement, bringing about the actual planning for the class entering in 2006, which is less than a year from now. Students receiving their applications materials are being told that if continued Medical Education Reform:  Medical Education Reform they come here, they may be going through an entire new curriculum experience. The design groups for the five substantive changes or components of the new curriculum that we are implementing are being chaired by true leaders in our medical community here. The Introduction to the Profession, which will be given for the first time in August of 2006, will introduce our students, over a two-week period, into this wonderful world of medicine and healthcare, of science, and of clinical care that is the profession of medicine. The group planning this is co-chaired by Kate Treadway and Phil Leder. The Fundamentals of Medicine, which is essentially a regrouping and reorganization of the first year and three quarters of our basic science instruction. Basic science including not only wet lab science but the social and behavioral sciences, is being rejuvenated by course directors meeting often for the first time to talk together about how to make the instruction the best it can be, and this group is chaired by Peter Howley and Barbara McNeil. The in-depth education experience will introduce the students in about the middle of their first year to opportunities, to menus of selections for what they can take for in-depth analysis, in-depth study during the course of their time here, and this is chaired by David Golan and Teri Flier. We will require students to elect an area of concentration and to work closely with a faculty member during their time, perhaps culminating in a thesis, perhaps culminating in some other demonstration of in-depth knowledge. The details of that are being worked out now. In many ways, the most innovative idea is the notion of preparing our students during a period of nine to 12 months in a principal clinical experience where they can be mentored, shepherded, and assisted along a pathway of professional and scientific learning in a clinical setting in which they can feel a closer attachment to the faculty and a closer loyalty, if you like, to the institutions in which they are working. We have some experiments in that direction, which I will tell you about in a moment. This very important endeavor is co-chaired by Steve Calderwood from the Mass General and by Ed Benz from Dana Farber. And then, finally, we want to return in the last year and a quarter for our students to some advanced experiences in clinical medicine and in research which will allow them to dig more deeply into sub-internships in clinical areas they may be interested in or to spend more time in laboratory work, remembering that 40 percent of our students now spend a fifth year before they graduate. There will be ample time during that last year and a quarter to engage in the broader experience, which may not come from being in a single hospital setting. Principal Clinical Experience:  Principal Clinical Experience Here we have the three individuals who have been very involved in the planning of the principal clinical year, Erik Alexander from the Brigham and Women’s Hospital, Steve Claderwood of Mass General, and Rich Schwarzstein from the Beth Israel Deaconess Medical Center. We currently have 12 students at the Brigham and Women’s Hospital and eight at the Beth Israel Deaconess who are now into their fourth month of an integrated series of clerkships where they are learning the principal components of a professional education at one site. Mass General has been planning and will introduce a modified institution-specific kind of experience beginning in July. We are now in a second year of an experience at the Cambridge City Hospital under the leadership of David Bor, David Hirsh, and Barbara Ogur, which took eight students last year and again this year, in an experience where they are being monitored closely to assess the outcome of that experience and to compare it in a scientific way with the experiences that other students are having who aren’t given that kind of special attention. Program in Medical Education:  Program in Medical Education Jane Neill Jules Dienstag I have already mentioned Jules's name—our wonderful leader in the Program for Medical Education—and part of his challenge over the summer has been to recruit a staff that can work closely with him. We are very pleased that Jane Neil has agreed to take a key role with Jules as associate dean. The Medical Education program is being restructured to make it more definitive in terms of what the society’s function is, what the masters of the societies view their roles to be, to develop a clearer sense of a curriculum committee that really will understand, manage, and suggest new ideas for the curriculum, and to place the academy in a new role. George Thibault will continue to lead the academy but with a new center for teaching excellence, much as the Bok Center at the Faculty of Arts and Sciences has become a center for the teaching of how to teach in the FAS setting. Graduate Degree Education:  Graduate Degree Education MD-MBA Systems Biology Chemical Biology MD-PhD in social science Graduate degree education: This year we introduced the first official MD-MBA at Harvard. I was amused when I came as dean; I met with Kim Clark not long afterwards to learn that medical students were considered too immature, were not old enough, had not had enough practical experiences to be considered as business school students, and that his professors would simply not allow it. So, that was where it stood for about five years and then we started talking again, and I am delighted to say that we have come now to an agreement on a five-year program that is specially tailored to the interests of medical and business school students, and we introduced the first class this September—three students who applied de novo and four students who entered the program from completing their first year. Barbara McNeil has been a key person managing the development of this. Peter Slavin, who is himself a graduate of both our medical school and the business school, has been actively involved, and Stan Finkelstein, who has been the lead curriculum person helping to put together the details, has made possible a program that I think will be quite remarkable. Nine students entered the new PhD program in systems biology. There were about 150 applicants that were received after it was approved last October. There were only nine months to get the whole process together. We wanted to metriculate six. So we accepted 12 and continued Graduate Degree Education:  Graduate Degree Education we got nine. And they are nine of the most remarkable people. They come from physics, from mathematics, computer science, and they are interested in applications of those areas to biology. Six students entered a new program in chemical biology and I would like to note immediately that the quality of that group was equal to the quality of the Systems Biology group, but must add, they are all women. So, six students arrived to study chemistry and biology, which is being co-directed by Jon Clardy and Greg Verdine. I should have said that Pam Silver, a professor of systems biology, is directing the graduate program in systems biology. And this year for the first time, with the leadership of Alan Brandt, we have established an MD-PhD program in the social sciences. Science Education Pipeline:  Science Education Pipeline Now, this is a little change that I want to share with you. These are middle school students who came here to participate in a program called PRISM. It is a three-week summer program in which they work through a case and at the end develop and perform a skit about the medical problem. Here the doctors are talking to a patient about balance and vertigo, and are learning about the vestibular system and how it works. This pipeline example, which Joan Reede in her role as dean for Diversity and Community Partnership has developed is just one of multiple programs that we have developed here with an interest in diversity but also with an interest in developing deep science interests and commitments on the part of young students. In the past year, nearly 900 K–12 students from our local schools have been through programs such as this. The National Academy of Sciences came out with a report just last week that some of you may have seen in the news clippings. In the past year, China graduated 600,000 engineers, India 350,000 engineers, the United States 70,000 engineers. The interest at the levels of our students in high school and college in science and engineering has been diminishing. And in terms of grade 12 aptitudes in the sciences, we are below 21 other countries in terms of the knowledge base that our students have. So, we take it as an obligation to provide a portion of the pipeline that hopefully will correct those inequities as we go forward. Research Across Disciplines —with convergence of platforms:  Research Across Disciplines —with convergence of platforms Systems Biology Chemical Biology Structural Biology, CMCD C. elegans protein interaction map In the past year, systems biology has recruited seven or eight faculty, depending on when you time their arrival. They have included a theoretical biologist, a physician, a mathematician, an engineer, a cell biologist, a physicist, a microbiologist mathematician, and a pure mathematician, Jeremy Gunawardena, who is learning biology. This group of people is a tribute to the leadership which was begun by Marc Kirschner, Lou Cantley, Tim Mitcheson, and Pam Silver to grow a field that is still defining itself: What is systems biology? The students entering the PhD program and the undergraduate course that these faculty are providing now at Harvard for the second year, will I think help define the field. This new physiology will take the dots on the cell maps that we read about in Nature and Science for each of the proteins that is identified and connect those dots in a way that will allow one to interpret function in a way that so far has been very difficult to do. In the case of chemical biology, we have recruited faculty in collaboration with the Dana–Farber Cancer Institute, where the resources for the recruitments were made possible through the Dana–Farber but the space was given to these two recruits here on the Quad. Natnael Gray and Ulrike Eggert are our new faculty members as a result of this collaboration. Structural biology under the umbrella of the Center for Molecular and Cellular Dynamics led by Steve Harrison is in the process of using a major new grant to secure a high-end electron microscope to further enhance the imaging capacity in that arena. Convergence of Platforms:  Convergence of Platforms Marc Vidal Here is an example of one type of science that is currently underway in our community. Marc Vidal, who is at the Dana–Farber Cancer Institute, is working on a program having to do with understanding the intimate connectivity of biological components in the C. elegans model. The C. elegans is a small roundworm which has 959 cells total, of which 305 are nerve cells, interestingly. It is a model because all of its cellular lineage has been defined and the genes that regulate many of its functions are known. The purpose of this work here is to develop a deeper understanding, and this is done in collaboration with workers in Colorado, in New York, and in Germany, to roughly map the molecular machines involved in the very early embryonic development of the flatworm. Here what they do is look at the expression profiling, that is, whether genes are turned on or off in a network. They then look at binding assays to see how proteins relate to each other. Then use RNA interference to selectively turn off genes to define their function. Then one can take the genetic and the proteomic components and create a profile of the connectivities among different activities within a single group of cells. They can then model this with molecular machine models that will allow them to predict not just the static state of a given set of interactions, but the dynamics of how it moves and changes over time. Collaborating Across Institutions:  Collaborating Across Institutions Allston Stem Cell Institute Broad Institute Dana Farber/Harvard Cancer Center NERCE/BEID Harvard Center for Neuro-degeneration and Repair (LDDN) Now we move to some collaborations across our institutions, the first is Allston. As you are aware, the Harvard Gazette published a rather detailed accounting of the geography and the early planning for the master development of Allston back in May. This has been accompanied over the summer with a series of interactive planning sessions and now we are in the process of engaging an architect to look at the design of a first building, which will be primarily in the area of life sciences, and presumably that architectural choice will be made within the next few months. If approval is obtained from the Boston Redevelopment Authority and the neighborhood and so on, ground could be broken as early as perhaps a year from now with completion of the first building sometime around 2010. We are impacted in this plan particularly in four ways. The first is that the science and technology committee, which Steve Hyman chaired, developed a profile of those programs which would by theory network most closely across the university to bring interdisciplinary, interfaculty research together. Again, it is really building upon the two programs we have already watched happen here. In fact, we are the best acts in town, I would say, or at the university—systems and chemical biology, bringing physics, chemistry, mathematics together with biology and to try to learn from each other. This creates anxiety on the part of us here in the Longwood area about the impacts of continued Collaborating Across Institutions:  Collaborating Across Institutions losing potentially some of our best people to the Allston site. And I would say that you will be hearing over the next few months a more lively and more apparent debate about exactly what the impacts of this might be. Although it is four or five years away, the actual planning for it, as we knew with our new research building, has to be fairly well completed before you go to final architectural designs. Chemical biology, systems biology, the Stem Cell Institute, and bioengineering are the four areas that impact our community. And it is not just our quad-based community, but our hospital-based side, particularly with respect to the Stem Cell Institute, which I will come to now. It has been assumed with the leadership of Doug Melton and the co-director of the Stem Cell Institute, David Scadden from the MGH, and with the active involvement from the Children’s Hospital, George Daley and Leonard Zon, that the Stem Cell Institute would find its home in Allston because that would be a site where one could separate out the resources that are obtained from private philanthropy to support the research from federal sources which do not allow research to be undertaken in components of the research that are at this point important. So, the Stem Cell Institute would presumably be part of this first building, but the details of how that will connect to our hospital faculty or to our quad-based faculty, and how they engage in that work really needs to be defined almost completely from de novo. The Broad Institute, which you will recall is a joint venture between Harvard University and MIT, the creation of which was led by Chuck Vest and Larry Summers. The Broad donation came from Eli and Edie Broad, who live in Los Angeles, and $100 million was committed with the understanding that Eric Lander would be the leader of the activity for the first five years. We are now into the third year. I serve on the operating committee, which meets quarterly together with the two provosts. Sam Thier is on that committee representing the hospital interest, and David Page, head of the Whitehead Institute, and we convene and go over with Eric the plans for recruitment, plans for programmatic development, relationship of the faculty to our hospitals and the medical school. I have to say that, in general, I think the whole idea has added an enormous amount of technologic and intellectual support to the Harvard medical community. The Dana–Farber Harvard Cancer Center has just gone through its first grant renewal. It was established six years ago with a five-year sizable National Cancer Institute comprehensive center core grant. It has now been reviewed highly favorably. We have not heard the final new budget. At a time when NIH is constrained and the NCI is in fact flat in its funding, we are not sure we will get the approved budget that the committee will recommend. This center continued Collaborating Across Institutions:  Collaborating Across Institutions has brought together more than 900 investigators, basic and clinical, across our Harvard network. It has resulted in the funding of seven SPOREs, specialized programs of research excellence, which have included major tumor categories, breast, prostate, lung, skin, lymphoma, etc., SPOREs that are hard to come by and the success of which could be characterized as a result of the Dana–Farber Harvard Cancer Center creating new collaborations, new interactions that wouldn’t have happened otherwise. NERCE/BEID: This is the New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, which was triggered by 9/11, and funded through the National Institutes of Allergies and Infectious Disease. We were awarded one of the first centers led by Dennis Kasper, who you recall stepped down from his role as dean of Academic Affairs to take charge of this. It has grown to be a major instrument for research across the quad, infiltrating in a good sense departmental activities in microbiology, in cell biology, in biological chemistry, and also as a resource for connectivity with our hospitals and, in fact, for the whole region, not just Boston, but New England. I think we owe Dennis a debt of gratitude for the success that he has brought to it. Yesterday we had a symposium with the Harvard Center for Neurodegeneration and Repair. We heard about recent advances from our faculty in the area of Alzheimer’s disease and have established a new group whose members will help us to generate new resources in our search for finding better ways to take charge of the difficult disorders of the central nervous system. Slide27:  NERCE/BEID This just shows you the growth of NERCE, coming back to the New England Regional Center of Excellence. The number of investigators from 2003 to 2005 who are involved climbed from 19 to 99, and we now are working with 46 different institutions throughout the Harvard Medical community and beyond. Laboratory for Drug Discovery In Neurodegeneration:  Laboratory for Drug Discovery In Neurodegeneration NCDDN — $8.99 million — 5 projects/year Drug development contract pending — 2 molecules 1 for Alzheimer’s 1 for Huntington’s One of the interesting developments of the Harvard Center for Neurodegeneration and Repair is a laboratory headed by Peter Lansbury, who was one of the speakers yesterday, which is really looking at, as he described it, bridging the gap between basic science and what the for-profit biotech and pharmaceutical industry is willing to invest in. That gap has been growing as pharmaceutical industries have taken less risk in terms of early development. We were awarded a national center with $9 million dollars, which allows us to work with several other universities across the country providing a site of training for people who come to work here with our laboratory. continued Laboratory for Drug Discovery In Neurodegeneration:  Laboratory for Drug Discovery In Neurodegeneration The first year’s projects have included projects proposed by faculty at Harvard; Duke; the University of California, San Francisco; and Kansas, and they have worked on parts of their ideas in our laboratories. In the LDDN’s own work we now have two molecules, one for Alzheimer’s and one for Huntington’s, that are moving on toward early potential of phase 1 studies. We are negotiating with a biotech firm to take these compounds the next step, and this firm intends to outsource some of its chemistry to China. This concept of having a university medical school-based laboratory for drug development is really quite unique and has been written about in a number of places. The proof, of course, will be in the pudding and whether, in fact, a drug has been developed here that we can point to as having happened as a result of this activity. Collaborating Globally:  Collaborating Globally Division of AIDS Social Medicine Harvard Health Publications Harvard Medical International Let’s go on to collaborating globally. There are four components of our international efforts that I want to highlight today: the Division of AIDS, the Department of Social Medicine, the Harvard Health Publications, and Harvard Medical International. This picture comes from the work of a student, a Castle Society student, Ted Lord, who is on a rotation at the Schweitzer Hospital in Gabon, where he came into contact with Jess, a six-year-old who is shown in the photo. He came in with burns over 30 percent of his body that the hospital there was unable to take care of. Ted worked with the local Schweitzer Foundation to bring Jess and his mom to Boston where Jess is getting the needed skin graphs and other free care, in this case, at the Shriners Hospital. Ted is one of five Harvard medical students who received Schweitzer Fellowships this year and one of 65 of our students doing international projects some time during the course of the past school year. The Harvard Medical School Division of AIDS is working at 10 sites, three in Asia, three in the Caribbean, and four in Africa. Faculty from the Department of Social Medicine are working on 15 projects involving collaborators in 11 different countries. Harvard Health Publications:  Harvard Health Publications Harvard Health Publications is an extraordinary set of activities, and I really hadn’t appreciated how much it accomplished. Twenty-one books were published, of which 600,000 copies were sold and there are eight more coming out next year. There are five newsletters that you have seen with a combined circulation of 640,000 per month. There are monographs, 46 of them in print. Magazine partnerships with Newsweek, Better Homes and Gardens, newspaper columns, and Web content with Intel-Health. Books: 21 published, 600,000 sold, 8 more due next year Newsletters: 5 titles, 640,000 per month Monographs: 46 in print, 100,000/yr sold Magazine partners: Newsweek, Better Homes and Gardens, others Weekly Newspaper Column, 60 papers, 5 million readers Web content: InteliHealth, 4 million page views per month, plus other sites Newsweek special issues:  Newsweek special issues Two full issues Sept 01, June 05 12 cover stories 30-40 pages each 20 million US readers, millions more in foreign language editions This was a most recent Newsweek issue, which you can see at the bottom says “with Harvard Medical School,” which came out in September. We have had 12 similar cover stories of 30 to 40 pages each through the course of the Newsweek venture, with 20 million U.S. readers for each. Global Reach of HMS pubs:  Global Reach of HMS pubs Print publications sold throughout Europe, Central and South America, Austraila, Japan, China Translated into Arabic, Chinese, Indonesian, Italian, Korean, Japanese, Polish, Spanish, Turkish Another publication that you probably do not know about is the Middle East Healthcare, which relies heavily on material from Harvard Health Publications newsletters as well as material from HMS WebWeekly. It is produced as part of Harvard Medical International’s project with Dubai Health Care City. Harvard Health Publications newsletters and other publications are sold throughout Europe, Central and South America, Japan, and China and are translated into many languages. Harvard Medical International:  Harvard Medical International Harvard Medical International is involved in a number of different countries. Here is an example of work in Mumbai with Harvey Makadon, who is speaking to a group of nurses at the Wockhardt Hospital about quality and safety initiatives. HMI has helped with the hospital system as it has been built from the ground up. It is only the second in India to receive accreditation from the Joint Commission International, which is a tribute to the quality of the care that has been put in place in this particular site. All of this fits the Harvard Medical International mission, which is "that all citizens of the world have access to high-quality healthcare in their own community." HMI’s 10th year:  HMI’s 10th year 40 programs — curriculum — CME — quality initiatives — research 22 countries 200 HMS faculty participated last year HMI is in its tenth year and it currently has 40 different programs involving curriculum advice to other medical schools, continuing medical education in a number of countries, establishing new quality initiatives, and research activities. Currently, we are working in 22 different countries and over 200 Harvard Medical School faculty participated last year in the work of HMI. A fact that is not widely appreciated is that this is an opportunity for our faculty, with honorarium support and travel support, to go and participate in their fields around the world. HMS Dubai Center Institute for Postgraduate Education and Research:  HMS Dubai Center Institute for Postgraduate Education and Research We are engaged in the most adventuresome project in HMI’s history in Dubai. This shows a Practi-Med course that was held in Dubai in December 2004. Bob Therer, who is from the Beth Israel Deaconess Medical Center, associate professor of surgery, has taken the position of chief academic officer and now spends most of his time in Dubai. I will have a chance to visit with him in a couple of weeks when I return for my sixth visit to the Dubai region. Slide37:  H HMS HSPH HSDM Allston FAS MIT McLean Mt Auburn NERPC CHA WI BI MGH/ Charlestown MGH SERI MEEI CBR BWH DFCI Joslin BIDMC CH H H H H H H H H H H JBCC As we wind this up, let me talk again about the nodes and the network of activities that are represented by the Harvard Medical community, and you can see the cluster here in the Longwood area, which I think is probably the largest cluster of biomedical activities in the world—the medical school, its principal hospitals. The Center for Blood Research, Judge Baker, which has just moved up the hill, Harvard School of Public Health, Harvard School of Dental Medicine. Let me give tribute to Bruce Donoff, who is with us today for his leadership as dean of the Harvard School of Dental Medicine. We have the Faculty of Arts and Sciences, Mount Auburn Hospital, McLean, New England Primate Research Center. We have MIT with the Whitehead and the Broad, Cambridge Health Alliance, Mass General, Mass Eye and Ear, Schepens Eye Research Institute, and, of course, the second MGH campus that is Charlestown. Slide38:  HSPH HSDM H H H H H HMS H H H H H Allston FAS MIT H To Nancy Andrews, who did this for me, I said, "Let’s just put down some of the connectivities that we know about just off the top of our heads, the interweaving of collaborative programs that connect the nodes." Slide39:  HSPH HSDM H H Harvard campus major hospital minor hospital MIT campus research institute H H H H H HMS H H H H H Allston FAS MIT H So, this is our community of extraordinary people. I would also like to thank Cynthia Walker, who has agreed to become our executive dean of Administration. We are enjoying working together. She has now taken a major leadership role for the team that she has been with now for over 20 years. Also the development staff Jeff has recruited is an eager, energetic, wonderful group of people who are going to help us pay for all the things we are talking about. Keeping the Nodes Humming:  Keeping the Nodes Humming Aging Center gift, others coming CHAVI Pioneer award to Junying Yuan Uncertainties — future NIH budget — utility costs And in conclusion, I wanted to mention just a couple of other things that have happened over the last few months. We were given an Aging Center gift from Paul Glenn, who is from California, to help the work in the Department of Pathology with David Sinclair. We expect there will be other resources that will be brought to bear in this important area. Ray Dolin has been intimately involved in a new project in AIDS vaccine development, called CHAVI, which was awarded to Duke University but with a good portion of the resources from that grant coming to Harvard Medical School faculty. This grant is going to add substantial resources to our work in vaccines. We were very pleased that Junying Yuan was awarded one of only 13 pioneer awards nationally from the NIH. She is in the Department of Cell Biology. I would conclude with some sobering notes about the contingencies, if you like, that we face going forward. Uncertainty about the NIH budget; the recommendations that have just come down from the budget office for next year show an increment of less than 1 percent for NIH. And as energy costs go up, this will also impact upon our day-to-day budget balancing. HMS Mission Statement:  HMS Mission Statement To create and nurture a community of the best people committed to leadership in alleviating human suffering caused by disease In the end, all of this networking and all of the nodal activities that we participate in I hope contribute to the mission that we have all been pursuing: to create and to nurture a community of the best people committed to making a difference in the world in alleviating human suffering caused by disease.

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