Skeletal Muscle Fatigue and Cellular Mechanisms

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Information about Skeletal Muscle Fatigue and Cellular Mechanisms
Healthcare

Published on May 31, 2014

Author: ttylim

Source: slideshare.net

  By: Izatty Lim (0308188)

Definition Cellular mechanism of muscle fatigue & recovery

 decline in muscle performance associated with muscle activity.  As fatigue sets in, o force in your muscles reduces, o muscle responses to brain stimuli reduces o activity levels decrease.  temporary and reversible condition continuous high-frequency stimulation repeated tetanic stimulation

Fatigue mechanisms have been found to be multifactorial.

Fuel depletion Metabolic by-products Neuromuscular events •Intramuscular ATP • Muscle glycogen • Blood glucose • Hydrogen ions (H+) in plasma and muscle • Inorganic phosphate (Pi) • Adenosine diphosphate (ADP) • Decreased ‘firing’ of the central nervous system • Impaired sodium (Na+) and potassium (K+) gradients

Problem: build up of lactic acid Problem: needs oxygen Problem: only make 1 ATP at a time (15-20s of activity) Ca2+

 Myosin: for cross-bridge cycling  Ca2+ ATPase: o terminate contraction, pump Ca2+ back into sarcoplasmic reticulum

 reduced maximum force-generating capacity  reduced myofibrillar Ca2+ sensitivity  reduced Ca2+ release ↓ force

• ACIDOSIS • H+ competes with Ca2+ for binding sites on troponin C • ↓ maximal Ca2+ activated force and Ca2+ sensitivity (slows the maximal shortening velocity and prolongs relaxation) • Burning sensation

Predominant energy system Likely causes of fatigue Types of recovery ATP/PC Fuel Depletion:  ATP & PC Rest recovery Lactic Acid Accumulation of metabolic by- products:  H+ (hydrogen ions)  Pi (inorganic phosphates) Non-dietary Active Recovery Massage Hydro/water based therapies e.g. contrasting via hot/cold baths Aerobic Fuel Depletion:  Glycogen stores, then fats Elevated body temperature leading to:  Dehydration Dietary High Glycemic Index foods Rehydration Non-dietary Active Recovery Massage Hydro/water based therapies

 http://www.ncbi.nlm.nih.gov/pubmed/18195089  http://www.mendeley.com/catalog/cellular-mechanisms- muscle-fatigue/  http://lib.bioinfo.pl/pmid:7576593  http://www.pc.maricopa.edu/Biology/thoffman/Co mmon201/MuscularSystem.pdf

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