Select-eV shaping the future of GC-MS (HTC-13, 2014 conference)

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Information about Select-eV shaping the future of GC-MS (HTC-13, 2014 conference)

Published on February 17, 2014

Author: markesint



Presentation given at HTC-13 in Bruges, Belgium, on Markes' BenchTOF time-of-flight mass spectrometers for gas chromatography. As well as the features that make BenchTOF essential in the modern laboratory, the presentation describes Select-eV – newly launched variable-energy electron ionisation technology for GC–MS. Many examples are provided that illustrate how both classical reference-quality EI mass spectra at 70 eV and enhanced molecular ions at lower energies can enhance detection of challenging analytes – all without any loss in sensitivity.

Select-eV – Shaping the future of GC–MS Laura McGregor, Nick Bukowski

What is the BenchTOF? • A reflectron time-of-flight mass spectrometer • Platform-neutral • Innovative design

BenchTOF technology Innovative design Differentially pumped source and analyser chambers High accelerating voltage Direct extraction optimises sensitivity Multi-stage reflectron optimises resolution

The result… …exceptional sensitivity for trace analytes RT: 3.50 - 5.65 NL: 3.62E4 m/z= 271.50272.50 MS 100812_13_ dbc_100812 154612 5.23 100 90 80 Relative Abundance 70 OFN 1 pg 60 50 40 30 20 10 0 3.60 3.72 3.6 Base Peak Retention Time : 5.23 Scan : 628 Intensity : 36173 3.86 3.95 3.8 4.0 4.22 4.33 4.2 4.47 4.50 4.68 4.4 4.6 Time (min) 4.8 4.95 5.0 5.19 5.2 Calculated values Noise Range : 3.99 - 4.19 minutes (24 scans) Baseline : 6 Signal To Noise : 2747 Standard Deviation : 13 5.48 5.4 5.6

Exceptional sensitivity Trace-level pesticides (20 pg of aldrin; EIC m/z 263) SIM quadrupole S/N ratio: 41 2 pg on column S/N ratio: 30 BenchTOF S/N ratio: 380

Variable-energy electron ionisation with no loss in sensitivity

Advantages of Select-eV ionisation • No source exchanges or reagent gases • No loss in sensitivity • Enhanced molecular ions and reduced fragmentation • No ionisation of carrier gas/background gases • Reduction of matrix impact Enhanced signal-to-noise and lower LoD for target analytes

Variable-energy ionisation Transition of fragmentation pattern aids structural elucidation 70 eV 16 eV 12 eV

Select-eV ionisation of alkanes Pentacosane (C25H52) 70 eV Molecular ion: 1.5% (800 counts) 14 eV Molecular ion: 26% (4000 counts)

The full presentation can be downloaded from the Markes website

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