ReaMetrix Hiv Reagent Portfolio

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Information about ReaMetrix Hiv Reagent Portfolio
Health & Medicine

Published on February 18, 2009

Author: zmanian

Source: slideshare.net

Description

ReaMetrix HIV Reagents

Management of HIV Infection in Resource Poor Settings Accurate & Affordable Reagent Alternatives

HIV in India – Current Status HIV Prevalence rate in India 0.36% 2.5 Million HIV Infections By year 2010, estimates indicate that there will be between 8-15 million HIV infected individuals Management of HIV Infection Providing Anti Retroviral therapy (ART) Immunophenotyping CD4 T-Lymphocyte Count Viral Load Assay – PCR – quantitate virus levels in blood CD4 counts are the single most important criteria to guide clinical decision-making on when to use ART

HIV Prevalence rate in India 0.36%

2.5 Million HIV Infections

By year 2010, estimates indicate that there will be between 8-15 million HIV infected individuals

Management of HIV Infection

Providing Anti Retroviral therapy (ART)

Immunophenotyping

CD4 T-Lymphocyte Count

Viral Load Assay –

PCR – quantitate virus levels in blood

ReaMetrix Solutions for CD4 Enumeration Dry-Tri T-STAT CD348 3 color single tube reagent for open flow Cytometers eg. BD FACScan ™, BD FACSCalibur ™, BC EPICS XL™) Dry-Tri T-STAT CD3445 3 color single tube reagent for open flow Cytometers (eg. BD FACScan™, BD FACSCalibur™, BC EPICS XL™) ReaPan 34845 4 color single tube reagent for open Flow Cytometers (eg. BD FACSCalibur™) Rea T count 2 color dual tube reagent for FACScount ™ Platform ReaPan 34G-38G 2 Color dual tube reagent for the Guava™ Platform

Dry-Tri T-STAT CD348

3 color single tube reagent for open flow Cytometers

eg. BD FACScan ™, BD FACSCalibur ™, BC EPICS XL™)

Dry-Tri T-STAT CD3445

3 color single tube reagent for open flow Cytometers

(eg. BD FACScan™, BD FACSCalibur™, BC EPICS XL™)

ReaPan 34845

4 color single tube reagent for open Flow Cytometers

(eg. BD FACSCalibur™)

Rea T count

2 color dual tube reagent for FACScount ™ Platform

ReaPan 34G-38G

2 Color dual tube reagent for the Guava™ Platform

ReaMetrix Assay Reagent Characteristics Methodology Absolute CD4 testing by flow Cytometry – gold standard method Employ simple Lyse/no wash protocol - single platform technology Convenience Provided as a ready to use format. No additional dispensing Unitized form Pre-dispensed reagents in unitized form – reduces pipetting errors Stability & storage Dried down reagents – do not require cold storage. No aggregation of antibodies & beads in dried form Simplified work flow Minimal hand on time - just require sample pipetting, reduced steps

Methodology

Absolute CD4 testing by flow Cytometry – gold standard method

Employ simple Lyse/no wash protocol - single platform technology

Convenience

Provided as a ready to use format. No additional dispensing

Unitized form

Pre-dispensed reagents in unitized form – reduces pipetting errors

Stability & storage

Dried down reagents – do not require cold storage. No aggregation of

antibodies & beads in dried form

Simplified work flow

Minimal hand on time - just require sample pipetting, reduced steps

ReaMetrix Assay Reagent Characteristics Accurate & reproducible Workshop approved antibody clones – provide excellent Analytical Specificity & Analytical Sensitivity Extensively validated reagents in various private & public labs in India Sample stability Processed samples can be stored for up to 7 days prior to analysis ( CV = 5.7% ). Affordable All of these attributes without compromising affordability Technical support ReaMetrix provides training on Cytometer and reagent ReaMetrix provides technical support online & through personal visits

Accurate & reproducible

Workshop approved antibody clones – provide excellent Analytical

Specificity & Analytical Sensitivity

Extensively validated reagents in various private & public labs in India

Sample stability

Processed samples can be stored for up to

7 days prior to analysis ( CV = 5.7% ).

Affordable

All of these attributes without compromising affordability

Technical support

ReaMetrix provides training on Cytometer and reagent

ReaMetrix provides technical support online & through personal visits

Dry-Tri T-STAT CD348 3 color single tube reagent Anti CD4 – Atto488* (FITC eq. dye) Anti CD8 – R-PE Anti CD3 – R-PE-Dy649* (Cy5 eq. dye) Provides absolute counts (Cells/µL) of CD3+, CD4+, CD8+ Cells & CD4/CD8 Ratio Validated with commercial reagents at NARI, YRG Care CE Marked reagent Reagents are suitable to run on open flow cytometers such as BD FACScan, BD FACSCalibur, Beckman Coulter EPICS-XL etc. Reagents supplied in Dry, Unitized Format * Dyes qualified by ReaMetrix to assure superior performance

3 color single tube reagent

Anti CD4 – Atto488* (FITC eq. dye)

Anti CD8 – R-PE

Anti CD3 – R-PE-Dy649* (Cy5 eq. dye)

Provides absolute counts (Cells/µL) of CD3+, CD4+, CD8+ Cells & CD4/CD8 Ratio

Validated with commercial reagents at NARI, YRG Care

CE Marked reagent

Dry-Tri T-STAT CD3445 3 color single tube reagent Anti CD4 – Atto488* (FITC eq. dye) Anti CD3 – R-PE-Dy649* (Cy5 eq. dye) Anti CD45 – R-PE Provides a bsolute counts (Cells/µL) of Absolute Lymphocyte Count (ALC), CD3+, CD4+, % CD4 Counts Validated with commercial reagents at leading path labs in India Suited for aged blood samples Reagents are suitable to run on open flow cytometers such as BD FACScan, BD FACSCalibur, Beckman Coulter EPICS-XL etc. Reagents supplied in Dry, Unitized Format * Dyes qualified by ReaMetrix to assure superior performance

3 color single tube reagent

Anti CD4 – Atto488* (FITC eq. dye)

Anti CD3 – R-PE-Dy649* (Cy5 eq. dye)

Anti CD45 – R-PE

Provides a bsolute counts (Cells/µL) of Absolute Lymphocyte Count (ALC), CD3+, CD4+, % CD4 Counts

Validated with commercial reagents at leading path labs in India

Suited for aged blood samples

ReaPan 34845 4 color single tube reagent, Anti CD4 – APC Anti CD8 – R-PE Anti CD3 – Atto488* (FITC eq. dye) Anti CD45 – PerCP Provides a bsolute counts (Cells/µL) of ALC, CD3+, CD4+, CD8+ Cells, % CD4 & CD4/CD8 Ratio Validated with BD multiTEST 4 color reagent at leading path. Lab in India. Suited for aged blood samples Designed for BD FACSCalibur dual laser flow Cytometer CE marked Reagents supplied in Dry, Unitized Format * Dyes qualified by ReaMetrix to assure superior performance

4 color single tube reagent,

Anti CD4 – APC

Anti CD8 – R-PE

Anti CD3 – Atto488* (FITC eq. dye)

Anti CD45 – PerCP

Provides a bsolute counts (Cells/µL) of ALC, CD3+, CD4+, CD8+ Cells, % CD4 & CD4/CD8 Ratio

Validated with BD multiTEST 4 color reagent at leading path. Lab in India.

Suited for aged blood samples

Designed for BD FACSCalibur dual laser flow Cytometer

CE marked

Rea T-Count Reagent Rea T-count CD3/CD4 & CD3/CD8 re agent Designed for BD FACSCount flow Cytometer Available as 2 color dual tube reagent for CD3+, CD4+, CD8+, CD4/CD8 ratio estimation Available as 2 color single tube reagent for CD3+, CD4+ estimation Alternative for FACSCount reagent Reagent validated at National HIV Immunology laboratory, Canada Zimbabwe Reagents supplied in Dry, Unitized Format

Rea T-count CD3/CD4 & CD3/CD8 re agent

Designed for BD FACSCount flow Cytometer

Available as 2 color dual tube reagent for

CD3+, CD4+, CD8+, CD4/CD8 ratio estimation

Available as 2 color single tube reagent for

CD3+, CD4+ estimation

Alternative for FACSCount reagent

Reagent validated at

National HIV Immunology laboratory, Canada

Zimbabwe

ReaPan Reagents for the Guava Platform ReaPan 34G 2 color single tube reagent Provides absolute counts (Cells/µL) of CD3+, CD3+CD4+ counts ReaPan 34G & 38G 2 color single dual reagent Provides absolute counts (Cells/µL) of CD3+, CD3+CD4+ & CD3+CD8+ counts Validated with Guava Reagent at KIMS, Bangalore Reagents supplied in dry, unitized format

ReaPan 34G

2 color single tube reagent

Provides absolute counts (Cells/µL) of CD3+, CD3+CD4+ counts

ReaPan 34G & 38G

2 color single dual reagent

Provides absolute counts (Cells/µL) of CD3+, CD3+CD4+ & CD3+CD8+ counts

Validated with Guava Reagent at KIMS, Bangalore

Summary… ReaMetrix supplies all reagents with ReaLyse, a buffer for lysing and fixing samples or ReaFix, a buffer for fixing samples after staining ReaMetrix has the capability to develop CD4+ enumeration solutions for any flow cytometer platform. ReaMetrix can customize solutions as per your need. Work is in progress for reagent development for other platforms.

ReaMetrix supplies all reagents with ReaLyse, a buffer for lysing and fixing samples or ReaFix, a buffer for fixing samples after staining

ReaMetrix has the capability to develop CD4+ enumeration solutions for any flow cytometer platform.

ReaMetrix can customize solutions as per your need.

Work is in progress for reagent development for other platforms.

Manufactured by ReaMetrix India Pvt. Ltd. 50-B, II Phase, Peenya Industrial Area Peenya, Bangalore 560058, India Ph: +91-80-28378693/5, Fax: +91-80-41172451 E-mail: info@reametrix.com www.reametrix.com Further details:

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