Pharmacokinetic process of Distribution

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Information about Pharmacokinetic process of Distribution
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Published on June 22, 2008

Author: dunkSD

Source: authorstream.com

Distribution : Distribution University of OklahomaNURS3182 June 21, 2008 Distribution : Distribution The movement of drugs throughout the body. 3 Major Factors of Distribution : 3 Major Factors of Distribution Blood flow to the tissues. Exiting the vascular system. Entering the cells. Blood Flow to the Tissues : Blood Flow to the Tissues Impaired Blood Flow Perfused Tissue Drug Delivery to the Organs : Drug Delivery to the Organs Exiting the Vascular System : Exiting the Vascular System Typical Capillary Beds : Typical Capillary Beds In most cases, drugs may pass through gaps between the cells in capillary walls unimpeded. The Blood-Brain Barrier : The Blood-Brain Barrier Only drugs that are lipid soluble or use a transport system can cross. Placental Drug Transfer : Placental Drug Transfer *Lipid-soluble and non-ionized compounds easily pass from the mother’s blood stream across the placenta into the fetus. Examples: Alcohol, Aspirin, and Accutane. *Highly polar, ionized, protein-bound compounds, and drugs that are substrates of P-glycoprotein do not pass as much from the maternal blood stream to the fetus. Examples:Folic acid, Vitamin B6, and thyroid medicine. Protein Binding : Protein Binding Entering Cells : Entering Cells Reference : Reference Medic8 (2008). Medication in Pregnancy. Medic8 Family Health Guide. Retrieved June 20, 2008, from http://www.medic8.com/healthguide/articles/medsinpregnancy.html Neligan, Pat (2002). Pharmokinetics. Retrived on June 21, 2008 from http://www.4um.com/tutorial/science/pharmak.htm Lehne, R. A. (2007). Pharmacology for Nursing Care. Pgs 35-37. St. Louis, Missouri. Saunders, Elsevier. Nicole Dinning Monica HandleyMichael Virrey : Nicole Dinning Monica HandleyMichael Virrey

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