Pharmacokinetic process of Distribution

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Information about Pharmacokinetic process of Distribution

Published on June 22, 2008

Author: dunkSD


Distribution : Distribution University of OklahomaNURS3182 June 21, 2008 Distribution : Distribution The movement of drugs throughout the body. 3 Major Factors of Distribution : 3 Major Factors of Distribution Blood flow to the tissues. Exiting the vascular system. Entering the cells. Blood Flow to the Tissues : Blood Flow to the Tissues Impaired Blood Flow Perfused Tissue Drug Delivery to the Organs : Drug Delivery to the Organs Exiting the Vascular System : Exiting the Vascular System Typical Capillary Beds : Typical Capillary Beds In most cases, drugs may pass through gaps between the cells in capillary walls unimpeded. The Blood-Brain Barrier : The Blood-Brain Barrier Only drugs that are lipid soluble or use a transport system can cross. Placental Drug Transfer : Placental Drug Transfer *Lipid-soluble and non-ionized compounds easily pass from the mother’s blood stream across the placenta into the fetus. Examples: Alcohol, Aspirin, and Accutane. *Highly polar, ionized, protein-bound compounds, and drugs that are substrates of P-glycoprotein do not pass as much from the maternal blood stream to the fetus. Examples:Folic acid, Vitamin B6, and thyroid medicine. Protein Binding : Protein Binding Entering Cells : Entering Cells Reference : Reference Medic8 (2008). Medication in Pregnancy. Medic8 Family Health Guide. Retrieved June 20, 2008, from Neligan, Pat (2002). Pharmokinetics. Retrived on June 21, 2008 from Lehne, R. A. (2007). Pharmacology for Nursing Care. Pgs 35-37. St. Louis, Missouri. Saunders, Elsevier. Nicole Dinning Monica HandleyMichael Virrey : Nicole Dinning Monica HandleyMichael Virrey

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