PG Depot

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Information about PG Depot

Published on July 12, 2016

Author: AnnaMarieHerrera


1. 1 1 PG Depot™ Phospholipid Gel Depot Technology for Sustained Release (1-7 days) LATITUDE Pharmaceuticals, Inc.’s Phospholipid Gel (PG) Depot™ technology is a versatile parenteral drug delivery platform for applications requiring the sustained release of small molecules, peptides, and proteins over 1-7 days. Key Advantages and Properties of the PG Depot™  Sustained release for 1-7 days  Small molecule, peptide and protein compatible  Up to 20% drug loading by weight  Protein-friendly: provides >6 month RT stability  Enzyme-friendly: activity, stability uncompromised  Tissue-friendly and wound compatible  No collagen or other animal products  Components all GRAS listed and compendial grade (USP, NP, EP)  Single phase, ready-to-use format; no pre-mixing prior to use  Injectable through fine needles  Dosing paradigm shift: from once or twice per day to once/week  Self administration-capable  Peakless or burst profile can be designed into final product  Simple and straightforward manufacturing  Autoclavable  ~$0.20-$2.00 vehicle cost/dose  Patent pending Technology Manufacturing Cost of Goods Drug Loading Burst Premixing, Resuspen RT Stable? PG Depot™ Simple Low ~15-20%` Optional No Yes Liposomes Complex High -5% Unavoidable Yes Collagen Complex High <10% ? No No SABER™ ? High ~30% ? Yes No PLGA Complex High ~5% Unavoidable Yes No PLGA Complex High ~5% Unavoidable Yes No

2. 2 2 LATITUDE Pharmaceuticals, Inc. | 9675 Businesspark Ave. San Diego, CA 92131 |Tel: 858-546-0924 | Fax: 858-546-0958 | (Right) A peakless PK profile engineered into the PG Depot™ to avoid Tmax issues. If desired, a burst release may be designed into the application. (Left) For the same API, the PG Depot™ can be adjusted to achieve longer or shorter efficacy. Licensing and feasibility studies Latitude’s PG Depot™ technology is available to expand the product possibilities and intellectual prop- erty space for your compound. Please contact LATITUDE to discuss how the PG Depot™ technology may address the sustained-release needs for your API. We recommend a quick turnaround, low cost feasibility study to explore the PG Depot™ potential for your compound.

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