advertisement

NM-5 (Neurotransmitter)

67 %
33 %
advertisement
Information about NM-5 (Neurotransmitter)
Education

Published on February 18, 2014

Author: farrukhfayyaz332

Source: authorstream.com

advertisement

Neurotransmitters: Neurotransmitters Husan Bano Associate Professor Department of Physiology Al- Tibri Medical College, Malir Isra university Learning Objectives: Learning Objectives At the end of this lecture, the students should be able to: Define neurotransmitter. Classify the neurotransmitter. Describe the synthesis and fate of acetylecholine . Describe the action of neurotransmitter. Describe the synthesis and fate of noradrenaline Neurotransmitters: Neurotransmitters DEFINITION: Neurotransmitters are the chemical substances which are release from nerve endings. More than 40 types of neurotransmitters are found in CNS. Classification Of Neurotransmitters : Classification Of Neurotransmitters EXCITATORY Acetylcholine Aspartate Dopamine Histamine Norepinephrine Epinephrine Glutamate Serotonin INHIBITORY GABA Glycine Neurotransmitters found in the nervous system: Synthesis Of Acetylcholine : : Synthesis Of Acetylcholine : In the cholinergic nerve fiber ,acetylcholine is synthesized in axon. It is synthesize, when choline combine with acetyl COA in the presence of enzyme acetyl- cholinetransferase . After synthesis ,stored in synaptic vesicles. PowerPoint Presentation:  Acetyl- choline - transferase Synthesis Of Acetylcholine : Acetylcholine Acetyl COA + Choline As soon as acetylcholine is synthesized, it is stored within synaptic vesicles . Synthesis Of Acetylcholine Cont…..: Synthesis Of Acetylcholine Cont….. Whenever needed , it is released from synaptic vesicles. Goes to the synaptic cleft, bind with postsynaptic receptors. Excite the postsynaptic membrane, if the neurotransmitter is excitatory in nature. After then it is destroyed by an enzyme called acetylcholinestrase PowerPoint Presentation: Ach. Synthesize from precursor in presences of enzyme Removal of Acetylcholine from the synaptic cleft:: Removal of Acetylcholine from the synaptic cleft: The neurotransmitters, acetylcholine hydrolyzed by enzyme present in the synaptic cleft “ Acetylcholinestrase ” giving choline , and acetate ions. Acetylcholine Choline + acetate ions Acetylcholinestrase Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine). : Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine). 1) First Step: Hydroxylation: In this step, tyrosine converted into DOPA This reaction is catalyzed by the enzyme tyrosine hydroxylase . It is irreversible reaction. Tyrosine DOPA OH Hydroxylation Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine).: Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine). 2) Second step: Decarboxylation : In this step, DOPA is converted into dopamine by decarboxylation . The deficiency of this enzyme can cause Parkinson’s disease. It is irreversible reaction. DOPA Dopamine decarboxylation . CO2 Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine).: Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine). 3) Third step: Hydroxylation: In dopamine again hydrooxylation takes place and dopamine is converted into nor-epinephrine. dopamine. Nor-epinephrine OH It is an irreversible reaction. The end product in noradrenergic cells is nor-epinephrine and the pathway ends her. Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine).: Catecholamine Synthesis (Dopamine, Norepinephrine and Epinephrine). 4) Forth step: Methylation : In this step, methylation takes place in nor epinephrine,and converted into epinephrine nor epinephrine epinephrine Methylation C H3 PowerPoint Presentation:   Neurotransmitter Molecule Derived From Site of Synthesis Acetylcholine Choline CNS, parasympathetic nerves Serotonin 5-Hydroxytryptamine (5-HT) Tryptophan CNS, chromaffin cells of the gut, enteric cells GABA Glutamate CNS Histamine Histidine hypothalamus Epinephrine synthesis pathway Tyrosine adrenal medulla, some CNS cells Norpinephrine synthesis pathway Tyrosine CNS, sympathetic nerves Dopamine synthesis pathway Tyrosine CNS Nitric oxide, NO Arginine CNS, gastrointestinal tract Summary: PowerPoint Presentation:  THANKS

Add a comment

Related presentations

Related pages

Neurotransmitter Analysis in Microdialysates with ALEXYS

Neurotransmitter Analysis in Microdialysates with ALEXYS® Lusi van Heerwaarden, Hendrik-Jan Brouwer, Martin Eysberg, Nico Reinhoud Antec, Industrieweg 12 ...
Read more

5-HT1E Receptor Research -- Neurotransmitter.net

The cloned human 5-HT1E receptor couples to inhibition ... (0.1-100 nM), 5-HT inhibited ... modulating the release of various neurotransmitters in the ...
Read more

Serotonin Research -- Neurotransmitter.net

Don't forget to check out Neurotransmitter.net's research index for a ... of Serotonin Neurons: Role in ... of 2.43 ± 0.81 nM. 5-HT1B receptors are the ...
Read more

Neurotransmitters (NT) & Neuromodulators (NM)

Neurotransmitters (NT) & Neuromodulators (NM) 1. Acetylcholine (NT) 2. Monoamines (NT; NM) 3. Amino Acids (NT; NM) 4. Peptides (NT; NM) 5. Lipid-like ...
Read more

neurotransmitter activity Glucose is the ajor nutrient ...

neurotransmitter activity Glucose is the ajor nutrient of neurons, therefore a form of radio active from PSYCHOLOGY 1000 at UWO
Read more

Fluorescent Dopamine Neurotransmitter Ligand, labeled with ...

Sigma-Aldrich offers Sigma-95199, Fluorescent Dopamine Neurotransmitter Ligand, labeled with Dansyl for your research needs. Find product specific ...
Read more

Alien Intracellular Calcium Chelators Attenuate ...

Alien Intracellular Calcium Chelators Attenuate Neurotransmitter ... nm (5-nm slit width), which ... et al. * Calcium Chelators Attenuate Neurotransmitter ...
Read more

Serotonin - ELISA - DLD Diagnostika GmbH - Online

Serotonin - ELISA Enzyme Immunoassay ... It is a well evaluated neurotransmitter of the ... • Microplate photometer (450 nm) 5. Sample Collection
Read more