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Published on December 31, 2007

Author: fazil

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Keys to Success in Securing NIDA/NIH Funding :  Keys to Success in Securing NIDA/NIH Funding Shakeh Kaftarian.Ph.D. Division of Epidemiology, Services and Prevention Research November 10, 2005 Vanderbilt University Steps to NIH Grant-Writing:  Steps to NIH Grant-Writing Have an idea Match your idea with an NIH Institute Match your idea to a current initiative Find a Project Officer to help you Complete your application Wait (for scientific and programmatic reviews) Wait some more Start revising (for administrative processing of the award) If project is strong as-is If project needs revisions Where can I get one of these “ideas”?:  Where can I get one of these “ideas”? GET CURRENT! Review the literature to see what’s been done before http://nihlibrary.nih.gov/Elecres/databases.htm Find out if other researchers are interested in similar ideas Check CRISP to see if there is any Federally-funded work being done currently in this area http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen Slide4:  Casting a critical eye over new data Match your idea with an Institute:  Match your idea with an Institute Many NIH Institutes may have relevance to your area of interest: NIDA (Drug Abuse) NIAAA (Alcohol Abuse & Alcoholism) NIMH (Mental Health) NICHD (Child Health & Human Development) See: http://www.nih.gov/icd/ for a list of NIH Institutes and their missions Find yourself a Project Officer (“Cruise Director”):  Find yourself a Project Officer (“Cruise Director”) Project Officer (or Program Official or PO) is a scientist with expertise in particular areas of research The PO can help you navigate the grants system (research priorities, current initiatives, application process) The PO can also help identify potential consultants and collaborators, instruments, etc. How do I find one of these Project Officers? :  How do I find one of these Project Officers? Search the Institute’s website NIDA: http://www.drugabuse.gov/about/organization/Organization.html Call the Institute’s main number Call someone you know Match your idea to a current initiative:  Match your idea to a current initiative NIH guide: http://grants1.nih.gov/grants/guide/index.html You can join a free listserve that will automatically email a list of all NIH initiatives that are announced each week: http://grants1.nih.gov/grants/guide/listserv.htm NIDA’s website: http://www.drugabuse.gov/funding/ Types of Initiatives:  Types of Initiatives Program Announcement (PA) Request for Applications (RFA) Program Announcement (PA):  Program Announcement (PA) Standing calls for applications in general areas No set-aside funds Rolling deadlines (Competes with all other grants in the Division) Requests for Application (RFA):  Requests for Application (RFA) One-time calls for applications in targeted areas Funds set-aside for meritorious applications Single deadline (Competes only with other applications in the same RFA) Mechanisms: :  Mechanisms: Fellowship Programs (F Series) Research Career Awards (K Series) Research Projects and Research Program Projects (R….., P01) Centers (P30, P50, P60) Training Programs (T Series) Cooperative Agreements (U Series) Fellowship programs: :  Fellowship programs: F31 Postdoctoral Fellowship (Minority or disabled) Up to 5 years F32 Postdoctoral Individual Award 3 years total support F33 Senior Fellow 2 years support Research Career Awards: :  Research Career Awards: K01 Mentored Research Scientist K02 Independent Scientist Award K07 Academic Career Award K08 Mentored Clinical Scientist K12 Mentored Clinical Scientist K23 Mentored Patient-Oriented Research K24 Mid-Career Investigator K25 Mentored quantitative Research Research Projects and Research Program Projects::  Research Projects and Research Program Projects: R01 Research Project (Traditional – $500K/year/5 yrs) R03 Small Grant ($50K/year/2 yrs) R03 B/START Small grant ($50K / pilot study) R13 Conference Grants ($25K / Conferences) R15 Academic Enhancement Research ($150K start-up for new faculty) R21 Exploratory/Developmental Grant (2 yrs/ collect data leading to R01; $275K) R37 Merit Award (Nominated by PO/ exceptional grant and PI – extends original R01 to twice duration) U01 Research Project (Cooperative Agreement) NOTE: Amounts and times may be exceeded with prior NIDA approval – contact program official minimum 6 weeks before deadline with full budget and justification. Research Projects and Research Program Projects: :  R41 (STTR) Phase 1 R42 (STTR) Phase 2 R43 (SBIR) Phase 1 R44 (SBIR) Phase 2 Research Projects and Research Program Projects: Centers: :  Centers: P20 Exploratory Centers P30 Core Center Grants P50 Specialized Centers P60 Comprehensive Centers NIH Roadmap:  NIH Roadmap Series of progressive initiatives to transform biomedical research capabilities and accelerate the advancement of research discoveries from bench to bedside http://www.nida.nih.gov/about/Roadmap/index.html Roadmap Themes:  Roadmap Themes New pathways to discovery Research teams of the future Re-engineering the clinical research enterprise Application Forms:  Application Forms Applications have use PHS 398 forms (but read the announcement carefully for exceptions) New forms will be used Electronic forms are on the website in Word or PDF format: http://grants1.nih.gov/grants/funding/phs398/phs398.html Scientific Decisions:  Scientific Decisions Study design Population Recruitment strategies Measures used Data collected Analyses needed Research team (PIs, consultants, clinicians) Budget Human Subjects Protections/IRB approvals HIPAA compliance Scientific Review Criteria (listed in the grant announcement):  Scientific Review Criteria (listed in the grant announcement) Significance scientific contributions, public health impact Approach theoretical justification, methods, data analytic plan Innovation creativity, charting new waters Investigator experience, publication record, strength of team Environment research-supportiveness of institution of agency Gender/Minority/Children Inclusion Human Subjects Protection Priority Scores:  Priority Scores Scientific merit judgments are quantified In theory, Priority Scores range from 100 – 500, where 100 = best possible score In practice, Priority Scores rarely exceed 300 because of “triaging” or “unscoring” In general, although there is wide variability, a Priority Score of 150 or lower has a good likelihood of funding Triaging or Unscoring:  Triaging or Unscoring Review committees are encouraged to identify the bottom half of applications as “unscored” “Unscored” does not mean that the project had no scientific merit; only that it had little chance of funding during that round of review Percentile Scores:  Percentile Scores Because funding decisions are made based on Priority Scores assigned by different review committees, percentile scores are usually calculated as a way of trying to standardize the Priority Scores Percentile Scores are not calculated for grants reviewed in ad hoc RFA committees, or for training grants reviewed in the training (i.e., “K”) committee In general, although there is great variability, a Percentile Score of 15% or lower has a good likelihood of funding Summary Statements (“Pink Sheets”):  Summary Statements (“Pink Sheets”) Priority Score Percentile Score Significance Approach Innovation Investigator Environment Gender/Minority/Children Human Subjects Budget The Process of Scientific Peer Review:  The Process of Scientific Peer Review Review Process for a Research Grant:  Review Process for a Research Grant National Institutes of Health Center for Scientific Review Assign to IC & IRG/Study Section Study Section Review for Scientific Merit Institute Evaluate for Relevance Advisory Councils and Boards Recommend Action Institute Director Takes Final Action University or Agency Initiates Research Idea Submits Application Allocates Funds Conducts Research Applications Submitted to NIH:  Applications Submitted to NIH Approximately 40,000 grant applications are submitted to NIH each year, of which 15-20% are funded Competing grant applications are received for three review cycles per year Typical Timeline for a New Individual Research Project Grant Application (R01):  Typical Timeline for a New Individual Research Project Grant Application (R01) There are three overlapping cycles per year: Submit in February (June, October) - Review in June (October, February) - Council in September (January, May) - Earliest award in December (April, July) Cycle 1 ---- Cycle 2 ---- Cycle 3 ---- Slide32:  Your application is here. RFA-DA-06-001 Enhancing Practice Improvement in Community-Based Care for Prevention & Treatment of Drug Abuse or Co-occurring Disorders :  RFA-DA-06-001 Enhancing Practice Improvement in Community-Based Care for Prevention & Treatment of Drug Abuse or Co-occurring Disorders RFA Philosophy:  RFA Philosophy Research-to-services AND Services-to-Research Research and service improvement: Adoption, implementation, and sustained use of science-based approaches Understanding factors that hinder adoption, implementation, and sustained use of science-based approaches Testing effectiveness of existing promising but unproven policies and practices Foundation for future research to facilitate continuous practice improvement Community-based Service Providers Are Primary Investigators (PI) in This RFA:  Community-based Service Providers Are Primary Investigators (PI) in This RFA Eligibility Requirement – Provider Organization :  Eligibility Requirement – Provider Organization A. Community-based Provider Organization   (1) An organization, an agency, or an association of organizations/agencies (National, State, or Regional) that deliver(s) services to prevent or treat (2) Must demonstrate sufficient patient load, N of sites, site size and diversity to study system-wide assessment of existing or newly adopted therapeutic and/or business policies and practices. Eligibility Requirement – Provider Organization :  Eligibility Requirement – Provider Organization (3) Applications are encouraged from a community-based organization with one or more of the following characteristics: - For-profit organizations - Non-profit organizations - Domestic Institutions - Faith-based or community-based organizations - Units of Local/State Tribal government What does sufficient patient load, number of sites, site size, & diversity mean? :  What does sufficient patient load, number of sites, site size, & diversity mean? Do you have enough statistical power to answer your research question? Will your results generalize to your whole organization? Will your results generalize to other provider organizations? When Thinking about an NIH Research Mechanism:  When Thinking about an NIH Research Mechanism CONSIDER!!! PI experience <-> Project complexity <-> Project budget Study Design:  Study Design Study design should: Match your research question(s) Be as rigorous as possible Be feasible – Don’t plan to do too much! Study design can be: Qualitative, quantitative, or a combination Experimental, quasi-experimental What Are Some “Researchable” Questions?:  What Are Some “Researchable” Questions? Readiness and Capacity for Practice Improvement :  Readiness and Capacity for Practice Improvement Purpose: Examine implementation of science-based practice X and its effects on treatment retention and abstinence. Did we implement practice X? Did the practice have the intended effect? How if at all did the intended effect contribute to patient outcomes? Readiness and Capacity for Practice Improvement :  Readiness and Capacity for Practice Improvement Purpose: Examine the implementation of evidence-based practice. Did you implement the service intervention proposed? Did the service intervention have the intended effect? How if at all did the intended effect contribute to patient outcomes? Systems-level Factors that Facilitate/Impede Continuous Practice Improvement :  Systems-level Factors that Facilitate/Impede Continuous Practice Improvement Purpose: Refine data management system to improve performance monitoring. How can we best monitor our performance, and what systemic data do we need to do it? What are our current data collection demands? What more do we need? How feasible are new data collection requirements, and how useful are the new performance measures? Systems-level Factors that Facilitate/Impede Continuous Practice Improvement :  Systems-level Factors that Facilitate/Impede Continuous Practice Improvement Purpose: Identify person centered, program specific and other contextual factors that enhance or impede engagement and retention in evidence based practice. What are the individual and group differences (religious and spiritual beliefs, traditions, and value systems) to engagement and retention of care? How can culturally appropriate interventions improve accessibility, usability, and sustainability of services in diverse populations? What are the contextual factors (family beliefs) that impact accessibility and sustainability of care? Costs and Cost-Effectiveness of Practice Improvement :  Costs and Cost-Effectiveness of Practice Improvement Purpose: Determine the best use of staff training budget. What are our current staff training needs? What are two training options for meeting those needs? Which of the two training options will yield the greatest benefit for the dollars spent? Don’t Go It Alone!:  Don’t Go It Alone! Science Project Management & Staffing Business Component Pulling the Proposal Together Questions:  Questions

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