Neurotransmitters and its mechanism of action

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Information about Neurotransmitters and its mechanism of action

Published on October 22, 2011

Author: sarathy4


Neurotransmitters and its mechanism of action: Neurotransmitters and its mechanism of action Presented by R.Parthasarathy INTRODUTION:: INTRODUTION: What is neurotransmitter Criteria General characteristics features Classification biochemical physiological Mechanism of action of individual chemical ANATOMY OF NERVE: : ANATOMY OF NERVE: Postsynaptic: Muscle  Contraction Neuron  Action potential Glands  Secretion DEFINITION:: DEFINITION: Neurotransmitters are the chemical substances which are responsible for transmission of an impulse through a synapse. Schematic diagram of synapse CRETIA: 50 substance are there: CRETIA: 50 substance are there Synthesized by pre-synaptic neurons with the help of synthesizing enzyme and stored in vesicles at axon terminal. Stimulation of nerve cause release of transmitters. Travels between pre to post- synpatic membrane. Associated with an enzyme system(inactivation). Mimic the effects of nerve stimulation outside. Drugs which modifies nerve stimulation also modifies transmitter action the similar way. Neuromediators or neurohormones: : Neuromediators or neurohormones : Neuromodulators : Eg : VIP,somatostatin,ckk,substance P etc Neuromodulators : ACTION OF NEUROTRANSMITTERS general characteristics: ACTION OF NEUROTRANSMITTERS general characteristics Neurotransmitter travels pre  post synaptic Receptors associated with Ion channels and enzyme (second messenger) Acts in milliseconds Activate both pre and post synaptic receptors. More transmitter interact both pre and post synaptically (Sp Rec & sp effects) CLASSIFICATION: BIOCHEMICALLY: CLASSIFICATION: BIOCHEMICALLY PYSIOLOGICALLY: PYSIOLOGICALLY EXCITATORY Eg:Acetylcholine Aspartate Dopamine Histamine Norepinephrine Epinephrine Glutamate Serotonin INHIBITORY GABA Glycine Excitatory neurotransmitters:: Excitatory neurotransmitters: Inhibitory neurotransmitters:: Inhibitory neurotransmitters: Acetycholine:: Acetycholine : SYNTHESIS: Vasodilation , cardiac inhibition, GI peristalsis; control of thought, mood, sleep, muscles, bladder, sweat glands Catecholamines:: Catecholamines : Dopamine: Control of movements(parkinsonism) Induction of vomiting Inhibition of prolactin secretion Stimulation of GnRH Schizophrenia SYNTESIS Serotonin:: Serotonin: SYNTHESIS: FUNCTIONS : Regulation Carbohydrate intake & Hypthalamic releasing hormone Pain inhibition Hallucinations and 5HT Depression of mood Histamine:: Histamine: SYNTHESIS: Amino acid:: Amino acid: SYNTHESIS: OVERVIEW: OVERVIEW . Neuropeptide transmitters:: Neuropeptide transmitters: General mechanism of action: General mechanism of action Slide 29: Acetylcholine esterase Slide 32: Thank you

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