Neurotransmitters and its mechanism of action

50 %
50 %
Information about Neurotransmitters and its mechanism of action

Published on October 22, 2011

Author: sarathy4


Neurotransmitters and its mechanism of action: Neurotransmitters and its mechanism of action Presented by R.Parthasarathy INTRODUTION:: INTRODUTION: What is neurotransmitter Criteria General characteristics features Classification biochemical physiological Mechanism of action of individual chemical ANATOMY OF NERVE: : ANATOMY OF NERVE: Postsynaptic: Muscle  Contraction Neuron  Action potential Glands  Secretion DEFINITION:: DEFINITION: Neurotransmitters are the chemical substances which are responsible for transmission of an impulse through a synapse. Schematic diagram of synapse CRETIA: 50 substance are there: CRETIA: 50 substance are there Synthesized by pre-synaptic neurons with the help of synthesizing enzyme and stored in vesicles at axon terminal. Stimulation of nerve cause release of transmitters. Travels between pre to post- synpatic membrane. Associated with an enzyme system(inactivation). Mimic the effects of nerve stimulation outside. Drugs which modifies nerve stimulation also modifies transmitter action the similar way. Neuromediators or neurohormones: : Neuromediators or neurohormones : Neuromodulators : Eg : VIP,somatostatin,ckk,substance P etc Neuromodulators : ACTION OF NEUROTRANSMITTERS general characteristics: ACTION OF NEUROTRANSMITTERS general characteristics Neurotransmitter travels pre  post synaptic Receptors associated with Ion channels and enzyme (second messenger) Acts in milliseconds Activate both pre and post synaptic receptors. More transmitter interact both pre and post synaptically (Sp Rec & sp effects) CLASSIFICATION: BIOCHEMICALLY: CLASSIFICATION: BIOCHEMICALLY PYSIOLOGICALLY: PYSIOLOGICALLY EXCITATORY Eg:Acetylcholine Aspartate Dopamine Histamine Norepinephrine Epinephrine Glutamate Serotonin INHIBITORY GABA Glycine Excitatory neurotransmitters:: Excitatory neurotransmitters: Inhibitory neurotransmitters:: Inhibitory neurotransmitters: Acetycholine:: Acetycholine : SYNTHESIS: Vasodilation , cardiac inhibition, GI peristalsis; control of thought, mood, sleep, muscles, bladder, sweat glands Catecholamines:: Catecholamines : Dopamine: Control of movements(parkinsonism) Induction of vomiting Inhibition of prolactin secretion Stimulation of GnRH Schizophrenia SYNTESIS Serotonin:: Serotonin: SYNTHESIS: FUNCTIONS : Regulation Carbohydrate intake & Hypthalamic releasing hormone Pain inhibition Hallucinations and 5HT Depression of mood Histamine:: Histamine: SYNTHESIS: Amino acid:: Amino acid: SYNTHESIS: OVERVIEW: OVERVIEW . Neuropeptide transmitters:: Neuropeptide transmitters: General mechanism of action: General mechanism of action Slide 29: Acetylcholine esterase Slide 32: Thank you

Add a comment

Related presentations

Related pages

Neurotransmitters - Chemistry Encyclopedia - structure ...

General Mechanism of Action Neurotransmitters are ... in the action of all neurotransmitters. ... binds to its receptor. These neurotransmitters ...
Read more

Neurotransmitter - Wikipedia, the free encyclopedia

Mechanism. Neurotransmitters are ... Ultimately it will create a new action potential at its axon ... the only direct action of a neurotransmitter is ...
Read more

Actions of Excitatory and Inhibitory Neurotransmitters

Actions of Excitatory and Inhibitory Neurotransmitters. ... Action of Inhibitory Neurotransmitters. If an action potential goes down the ... B released its ...
Read more

Dopamine - Wikipedia, the free encyclopedia

The production of dopamine sulfate is thought to be a mechanism for detoxifying dopamine that ... Other neurotransmitters, such ... action makes its ...
Read more

What Are Neurotransmitters?

Neurotransmitters are ... a neurotransmitter is released from the axon terminal after an action ... There must be a reuptake mechanism or ...
Read more

Neuroscience For Kids - neurotransmitters

Neuroscience For Kids . ... Inactivation can be through a reuptake mechanism or by an enzyme that ... The action of neurotransmitters can be stopped by ...
Read more

Mechanism of Action | NIDA for Teens

Mechanism of Action Methamphetamine acts on the pleasure circuit in the brain by altering the levels of certain neurotransmitters ... but its effects ...
Read more