Neurogenesis and Neurodegenerative diseases

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Information about Neurogenesis and Neurodegenerative diseases
Health & Medicine

Published on March 9, 2014

Author: mattspaul



Slides from Danial Naqvi and Kuran Pahwa's talk on Neurogenesis, and the way exercise can reduce the symptoms of neurodegenerative diseases such as Alzheimers.

“The growth and development of Nervous tissue”  Used to be thought that it only occurred in youth  Recent evidence strongly suggests it does occur in adults as well 

„I please‟  Simulated/medically ineffectual treatment for a disease or other medical condition intended to deceive the recipient 

Brain-Derived Neurotrophic Factor  First isolated – Pig brains, 1982 (Barde et al.)  Similar to Nerve growth factor 

1998 – running increases BDNF levels in the hippocampus of mice  1999 – mice running increases cell proliferation in part of hippocampus 

In Humans:  2010 (Kramer et al.)– Aerobic exercise increases hippocampal volume by about 2% in 1-2 years 

   Help memory formation of how food was hunted or predators were escaped And/or Cell proliferation – uses lots of energy; Promise of energy replacement from food

Associated with Long-term Potentiation (a mechanism for memory formation)

Offset  Neurodegenerative  diseases! 


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