Necrosis

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Information about Necrosis
Health & Medicine

Published on November 8, 2008

Author: drtbalu

Source: slideshare.net

Description

This presentation describes tissue necrosis

NECROSIS Dr. R. Geetha M.D. Professor Department of Pathology SMC

DEFINITION OF NECROSIS Spectrum of morphologic changes that follows cell death in living tissues.

CAUSES OF NECROSIS ISCHEMIA PHYSICAL AGENTS CHEMICAL AGENTS IMMUNOLOGICAL INJURY

PATHOGENESIS OF NECROSIS 1.Denaturation of intracellular proteins. 2.Enzymatic digestion of the cell.

MORPHOLOGY CYTOPLASMIC CHANGES Increased eosinophilia of cytoplasm Glassy homogeneous appearance Cytoplasm is vacuolated,moth eaten Calcification of dead cells. Appearance of myelin figures Generation of calcium soaps

NUCLEAR CHANGES 1. KARYOLYSIS Fading of basophilia of chromatin Due to DNAase activity.

2. PYKNOSIS Nuclear shrinkage and increased basophilia

3.KARYORRHEXIS Fragmentation of pyknotic nucleus

TYPES OF NECROSIS Coagulative necrosis Liquefactive necrosis Caseous necrosis Fat necrosis Fibrinoid necrosis

COAGULATIVE NECROSIS Preservation of general tissue architecture-tombstone appearance of the cells. Affected tissue is firm Denaturation of structural proteins and enzymatic digestion of cells. Example – Heart, kidney,spleen.

NORMAL COAGULATIVE HEART NECROSIS

COAGULATIVE NECROSIS HEART

COAGULATIVE NORMAL KIDNEY NECROSIS

NORMAL SPLEEN COAGULATION NECROSIS

LIQUIFACTIVE NECROSIS The tissue becomes liquid viscous mass Material is creamy yellow in color Seen in brain, abscess.

LIQUEFACTIVE NECROSIS BRAIN

LIQUEFACTIVE NECROSIS BRAIN

NORMAL BRAIN LIQUEFACTIVE NECROSIS

LIQUEFACTIVE NECROSIS BRAIN

GANGRENOUS NECROSIS Wet gangrene Dry gangrene Gas gangrene

WET GANGRENE Occurs in moist tissues like mouth, bowel, lung, cervix Diabetic foot Bed sores

WET GANGRENE INTESTINE

WET GANGRENE

DRY GANGRENE Toes and feet due to arteriosclerosis Thromboangitis obliterans Raynaud disease Trauma

DRY GANGRENE

WET GANGRENE DRY GANGRENE Bowel Limb Venous obstruction Arterial obstruction Moist,swollen,dark Dry, shrunken, black No clear line of Presence of line of demarcation demarcation Bacteria present No bacteria Prognosis poor Prognosis better

GAS GANGRENE Wet gangrene caused by gram positive anaerobic bacteria Seen in muscle and in colon

GAS GANGRENE

CASEOUS NECROSIS Type of coagulative necrosis Seen in tuberculous infections Tissue is cheesy white in appearance The tissue architecture is preserved

CASEOUS NECROSIS LUNG

CASEOUS NECROSIS LUNG

CASEOUS NECROSIS LYMPHNODE

CASEOUS NECROSIS LYMPH NODE

CASEOUS NECROSIS

CASEATION NECROSIS LYMPH NODE

FAT NECROSIS Seen in pancreas, breast In acute pancreatitis ,activated lipase causes fat necrosis. Grossly visible chalky white areas. Presence of shadowy outlines of necrotic cells.

FAT NECROSIS

FAT NECROSIS

FIBRINOID NECROSIS Deposition of fibrin like material Seen in immunologic cell injury, hypertension ,peptic ulcer.

FIBRINOID NECROSIS

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