advertisement

MS: In a Nutshell

50 %
50 %
advertisement
Information about MS: In a Nutshell
Health & Medicine

Published on November 16, 2008

Author: LaurenElissa

Source: slideshare.net

Description

An overview of Multiple Sclerosis: the disease mechanism, the causes, the treatments
advertisement

MS: IN A NUTSHELL The what and the why This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ or send a letter to Creative Commons, 171 Second Street, Suite 300, San Francisco, California, 94105, USA.

MS IS AN AUTOIMMUNE DISEASE Instead of fighting off foreign objects (like viruses) your body’s immune system gets confused and attacks your own cells

Instead of fighting off foreign objects (like viruses) your body’s immune system gets confused and attacks your own cells

THE TARGET OF THIS ATTACK IS THE PROTECTIVE COATING, THE MYELIN, OF THE NERVE CELLS IN YOUR BRAIN AND SPINAL CORD http://training.seer.cancer.gov/module_bbt

THIS ATTACK LEAVES BEHIND SCARS, CALLED SCLEROSES. When the myelin is damaged, signals from your brain get interrupted, causing the symptoms of multiple sclerosis. Multiple sclerosis = many scars

WHEN THE MYELIN IS DAMAGED, SIGNALS FROM YOUR BRAIN GET INTERRUPTED, CAUSING THE SYMPTOMS. Fatigue Numbness Balance, walking problems Coordination problems Bladder and bowel dysfunction Vision problems Dizziness and vertigo Pain Cognitive impairment Depression Tremor Speech disorders Symptoms vary over time and from person to person Source: www.nationalmssociety.org

Fatigue

Numbness

Balance, walking problems

Coordination problems

Bladder and bowel dysfunction

Vision problems

Dizziness and vertigo

Pain

Cognitive impairment

Depression

Tremor

Speech disorders

FOUR TYPES OF MULTIPLE SCLEROSIS

EXCEPT IN VERY RARE CASES, MS IS NOT FATAL AND USUALLY DOES NOT SHORTEN LIFE SPAN

WHAT CAUSES MS? GENETICS ENVIRONMENT INFECTIOUS BEHAVIOR

GENETICS Twice as common in women Most common in Caucasians of N. European ancestry Heredity Risk in general population = 1/750 Risk if close relative is affected = 1/40 Risk if identical twin is affected = 1/25 Scientists have found, to-date, 50% of the factors responsible for the genetic susceptibility to MS Sources: National MS Society; Gregory, G., Schmidt, S., Seth, P. et al. (2007). Interleukin 7 receptor a chain (IL7R) shows allelic and functional association with multiple sclerosis. Nature Genetics, (39) 9, 1083-1091.

Twice as common in women

Most common in Caucasians of N. European ancestry

Heredity

Risk in general population = 1/750

Risk if close relative is affected = 1/40

Risk if identical twin is affected = 1/25

Scientists have found, to-date, 50% of the factors responsible for the genetic susceptibility to MS

INFECTIOUS Epstein-Barr If results in mononucleosis, 2-3 times increased risk factor Human Herpes Virus 6 Associated more (and at higher levels) in people with MS versus other autoimmune disorders Sources: Ascherio, A. & Munger, K. (2008) Epidemiology of multiple sclerosis: from risk factors to prevention. Seminars in Neurology, 28 (1), 17-28. ; Virtanen, J.O., Farkkila, M., Multanen, J. et al. (2007). Evidence for human herpesvirus 6 variant A antibodies in multiple sclerosis: diagnostic and therapeutic implications. Journal of NeuroVirology, 13, 347-352.

Epstein-Barr

If results in mononucleosis, 2-3 times increased risk factor

Human Herpes Virus 6

Associated more (and at higher levels) in people with MS versus other autoimmune disorders

ENVIRONMENT Vitamin D Protective factor Twin studies Reduced risk in Norway coastal villages with higher fish consumption Latitude Gradient Risk reduced in populations closer to equator Sources: Islam, T., Gauderman, W.J., Cozen, W. & Mack, T.M. (2007). Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology, 69, 381-388; Ascherio & Munger, 2008

Vitamin D

Protective factor

Twin studies

Reduced risk in Norway coastal villages with higher fish consumption

Latitude Gradient

Risk reduced in populations closer to equator

BEHAVIOR Smoking Risk factor for developing MS Associated with increased risk of transition from relapsing-remitting MS to secondary-progressive MS Sources: Ascherio & Munger, 2008

Smoking

Risk factor for developing MS

Associated with increased risk of transition from relapsing-remitting MS to secondary-progressive MS

THERE IS NO CURE FOR MS Currently several disease-modifying treatments exist to reduce the number of relapses All injection or intravenous-based Rehabilitation therapy can help to promote or maintain function Severe exacerbations may be treated with corticosteroids

Currently several disease-modifying treatments exist to reduce the number of relapses

All injection or intravenous-based

Rehabilitation therapy can help to promote or maintain function

Severe exacerbations may be treated with corticosteroids

ON THE HORIZON Several new oral therapies are in trials Continued work to determine remaining genetic risk factors Researchers are working with several techniques aimed to repair damaged myelin For more information, visit www.nationalmssociety.org

Several new oral therapies are in trials

Continued work to determine remaining genetic risk factors

Researchers are working with several techniques aimed to repair damaged myelin

Add a comment

Related presentations

Related pages

In a Nutshell - Microsoft Store

Kostenlos erhältlich + + Groove Music Pass 30 Tage kostenlos testen Mit Groove Music Pass anhören
Read more

In A Nutshell - Microsoft Store

Microsoft Lumia Zubehör Software Office Windows Weitere Software Apps ... In A Nutshell Eliza Deangeles.
Read more

Microsoft In a Nutshell - YouTube

Microsoft In a Nutshell Mattjonas. Subscribe Subscribed Unsubscribe 32 32. ... Microsoft Build Conference 2015 in a Nutshell - Duration: 3:04.
Read more

Microsoft (In a Nutshell) - YouTube

Microsoft (In a Nutshell) neverangry18's channel. Subscribe Subscribed Unsubscribe 21 21. ... Standard YouTube License; Show more Show less ...
Read more

Project Westminster in a nutshell | Building Apps for Windows

Hi, I’m Kiril Seksenov an Engineer on the Microsoft Edge Web Apps team, I’m so happy to talk to you in depth about Project Westminster. About Universal ...
Read more

How do you explain MS in a nutshell? | MS Trust

Explaining MS to people can be really difficult at the best of times. Explaining MS to people when you are newly diagnosed is even harder.
Read more

MS Office 2007 in a Nutshell: Sanjay Saxena: 9788125950363 ...

MS Office 2007 in a Nutshell [Sanjay Saxena] on Amazon.com. *FREE* shipping on qualifying offers. MS Office 2007 in a Nutshell teaches the basic operations ...
Read more

CRM & Sales Management for Small Businesses - Nutshell

Nutshell makes it easy for teams to get organized, sell smarter, and build customer relationships that last.
Read more

Nutshellcrm auf Microsoft Azure Marketplace

Was ist Azure? Lernen Sie die Grundlagen der Microsoft-Cloudplattform kennen. Eine Cloud, der Sie vertrauen können Erfahren Sie mehr über Sicherheit ...
Read more