Published on June 27, 2016
1. METABOLIC RISK FACTORS IN CHILDREN WITH ASYMPTOMATIC HEMATURIA Francisco Rodolfo Spivacow, Elisa Elena del Valle, Paula Gabriela Rey Dr.Mohammad Reza Razavi Dr.Mohammad Mahdi Shater
2. INTRODUCTION • Hematuria is one of the most common genitourinary abnormalities in children • clinical presentations • associate signs and/or symptoms , past medical history, family history • Idiopathic or benign hematuria • Some of these patients may subsequently suffer from kidney stones with hypercalciuria , hyperuricosuria , or hyperoxaluria , with most of these having a positive family history of urolithiasis
3. INTRODUCTION • The aim of this study was to evaluate the clinical presentation, family history, and metabolic risk factors of 60 children with asymptomatic hematuria without kidney stones
4. PATIENTS & METHODS • retrospective and cross-sectional analysis • patients under 16 years of age who were referred to our institution between 1996 and 2012 for evaluation of metabolic risk factors • referred to our institution by pediatric nephrologists and came from the general population • Negative for any explained cause of hematuria(PMH, DH ,…) • Family history of kidney stones
5. PATIENTS & METHODS • Sampling • Blood sample • Urine sample Hypercalciuria (HC), i.e., excretion of >4 mg/kg/day urinary calcium Hyperoxaluria (OX), i.e., overproduction of oxalate [>50 mg/1.73 m2 body surface area (BSA)/day] in the kidneys Hypocitraturia (CiT), i.e., urinary excretion of <400 mg citrate/g creatinine Hypomagnesuria (MG), i.e. urinary excretion of <1.24 mg magnesium/kg body weight/day Hyperuricosuria (HU), i.e., urinary excretion of excess amounts of uric acid (>815 mg/1.73 m2 BSA/day).
6. RESULTS • Study • Family history of renal stone • At least one urinary metabolic abnormality was present in 49 patients, while 11 patients had no metabolic abnormality. • Befor metabolic study
7. RESULTS • Single urinary metabolic risk factors
8. RESULTS • Multiple urinary metabolic risk factors
9. RESULTS • The most common urinary risk factor was idiopathic hypercalciuria (single or associated), which was found in 43.5 % of patients, followed by hypocitraturia (single or associated), present in 31.7 %. Unduly acidic urine pH as a single abnormality was found in 10 % of this pediatric patient population.
10. RESULTS • Metabolic risk factors in children with hematuria and in pediatric kidney stone- formers
11. CONCLUSIONS • Asymptomatic idiopathic hematuria in pediatric patients may often be associated to different urinary biochemical abnormalities, similar to what is observed in pediatric kidney stone-formers. • Long-term monitoring of children with hematuria and metabolic disorders may clarify the true association with kidney stone disease. • Finally, hematuria of unknown etiology demands a biochemical risk factor evaluation that allows definition of its cause and treatment
1. Pediatr Nephrol. 2016 Jul;31(7):1101-6. doi: 10.1007/s00467-015-3282-4. Epub 2016 Feb 25. Metabolic risk factors in children with asymptomatic hematuria.
Methods. To identify possible urinary risk factors for hematuria in children, we retrospectively evaluated clinical onset, family history, and metabolic ...
PubMedID: 26913725 | Metabolic risk factors in children with asymptomatic hematuria. | Pediatric nephrology (Berlin, Germany) | 5/26/2016
Physician Assistant Article: Metabolic risk factors in children with asymptomatic hematuria
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... Hypercalciuria in Children with Hematuria. ... and asymptomatic gross hematuria in children . ... Metabolic risk factors in children with ...
Metabolic risk factors in children with urolithiasis: ... macroscopic hematuria, pyuria, urinary metabolic ... the stones may remain asymptomatic for a ...
Metabolic risk factors in children with asymptomatic hematuria. ... #Asymptomatic hematuria, #Children, ... #Metabolic risk factors,
... from definition and diagnosis through risk factors and ... cause of hematuria in children but is ... value of asymptomatic hematuria ...