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Medication Treatment Failure And Ect

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Information about Medication Treatment Failure And Ect
Health & Medicine

Published on January 18, 2009

Author: vdbroekw

Source: slideshare.net

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You can view the text as pdf here at labmeeting
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Medication Resistance and ECT. Is there a problem? by Walter van den Broek

 

The indication for ECT has changed: Medication Resistant Depression.

Should you worry about that?

You’re concerned about medication resistance and response to ECT p =0.004 p <0.05 Prudic, J et al. Journal of Psychiatric Research 1990

This didn’t help to resolve your concern Prudic, J. et al. Am J Psychiatry, 1996 ATHF<3, n=18 ATHF 3 or more, n=36 Response 94% 64%

 

Medication resistance according to the ATHF does not influence remission and response to subsequent ECT

van den Broek, et al, Journal of Clin Psychopharmacology 2004

Co variables and their fate

Characteristics of the treatment TCA Lithium MAO ECT

Medication resistance with TCA and lithium does not influence remission and response to subsequent ECT

SSRIs are less efficacious than TCAs with depressed inpatients

Comparison of imipramine and lithium addition or fluvoxamine and lithium addition

ECT after Lithium addition Journal of Clin Psychiatry in press

Others haven’t found an influence of ATHF medication resistance on response to subsequent ECT

Real World Patients?

Husain et al, Journal of Affective Disorders, 2004.

CORE

 

p =0.004 p <0.05 Prudic, J et al. Journal of Psychiatric Research 1990

Prudic, J. et al. Am J Psychiatry, 1996 ATHF<3, n=18 ATHF 3 or more, n=36 Response 94% 64%

 

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