Medical Statistics Part III

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Information about Medical Statistics Part III
Health & Medicine

Published on March 9, 2014

Author: ramachandrabarik




Sampling Medical Statistics Part-III

Sample is soul of statistics

Distinguish Statistic Response of a sample with respect to a particular variable is called statistic and it is expressed as mean, median, mode, and so on Statistics Statistics is the study of the collection, organization, analysis, interpretation and presentation of data


Key words

External validity: Sample touches pupulation

The concept of sampling: External validity Sampling is the process of selecting units (e.g., people, organizations) from a population of interest so that by studying the sample we may fairly generalize our results back to the population from which they were chosen.

Two ways to get sample • Sampling Model • Proximal Similarity Model

Sampling Model • Start by identifying the population you would like to generalize to • Draw a fair sample from that population • Conduct your research with that sample • Generalize your results back to the population •

Limitation of Sampling Model • 1st :Don't know at the time of your study who you might ultimately like to generalize to • 2nd :May not be easily able to draw a fair or representative sample • 3rd : it's impossible to sample across all times that you might like to generalize to (like next year)

Sampling Model

Proximal Similarity Model • • • • • 'Proximal' means 'nearby‘ 'similarity' means... well, it means 'similarity‘ Proximal similarity was suggested by Donald T. Campbell as an appropriate relabeling of the term external validity Begin by thinking about different generalizability contexts and developing a theory about which contexts are more like our study and which are less so For instance, we might imagine several settings that have people who are more similar to the people in our study or people who are less similar. This also holds for times and places. When we place different contexts in terms of their gradient of similarity relative similarities, we can call this implicit theoretical a . Once we have developed this proximal similarity framework, we are able to generalize. How? We conclude that we can generalize the results of our study to other persons, places or times that are more like (that is, more proximally similar) to our study. Notice that here, we can never generalize with certainty -- it is always a question of more or less similar.

Proximal Similarity Model

Threats to sampling • The results of sample analysis may not exactly fits people when all the three parameters of epidemiology(time,place and person ) related in different setting

Improving quality of sample • Accept random sample • Assure that the respondents participate • Keep your dropout rates low • If there is variation in sampling, define at starting only to have proper external validity

Behaviour of a sample across a bell curve

standard error • • • • • The standard deviation of the sampling distribution tells us something about how different samples would be distributed. In statistics it is referred to as the standard error In sampling contexts, the standard error is called sampling error Sampling error gives us some idea of the precision of our statistical estimate A low sampling error means that we had relatively less variability or range in the sampling distribution The greater your sample size, the smaller the standard error

Methods of sampling • Probability • Non Probability

Probability vs. Non Probability Probability  Random selection during sampling  Depends upon the rationale of probability theory  Odds or probability that we have represented the population well  Estimate confidence intervals for the statistic  Best preferred  More accurate and rigorous Non Probability  Sampling does not involve random selection  Cannot depend upon the rationale of probability theory  May or not represent the population well  It is preferred over probability in situation where randomization is not possible

Probability • A probability sampling method is any method of sampling that utilizes some form of random selection. In order to have a random selection method, you must set up some process or procedure that assures that the different units in your population have equal probabilities of being chosen

Keywords • N = the number of cases in the sampling frame • n = the number of cases in the sample • NCn = the number of combinations (subsets) of n from N • f = n/N = the sampling fraction

Probability: Random Sampling Single stage=Simple Random Simple Stratified Systematic Cluster (Area) Multi-Stage

Simple • • Objective: To select n units out of N such that each NCn has an equal chance of being selected. • • Simple random sampling is simple to accomplish and is easy to explain to others • • Procedure: Use a table of random numbers, a computer random number generator, or a mechanical device to select the sample A fair way to select a sample, it is reasonable to generalize the results from the sample back to the population Simple random sampling is not the most statistically efficient method of sampling just because of the luck of the draw, not get good representation of subgroups in a population To deal with these issues, we have to turn to other sampling methods

Stratified :Proportional or quota Divide population into homogeneous subgroups and then taking a simple random sample in each subgroup: and it should be o non-overlapping groups (i.e., strata) N1, N2, N3, ... Ni, such that N1 + N2 + N3 + ... + Ni = N. Then do a simple random sample of f = n/N in each strata.


Cluster (Area) :Wider geographical territory • Divide population into clusters (usually along geographic boundaries) • randomly sample clusters • measure all units within sampled clusters

Multi-Stage In most real applied social research, we would use sampling methods that are considerably more complex than these simple variations. The most important principle here is that we can combine the simple methods described earlier in a variety of useful ways that help us address our sampling needs in the most efficient and effective manner possible. When we combine sampling methods, we call this multi-stage sampling

Non Probability • Purposive[more commonly used]:planned • Accidental, Haphazard or Convenience Sampling

Purposive[more commonly used]:planned • Modal Instance Sampling • Expert Sampling • Quota Sampling • Heterogeneity Sampling • Snowball Sampling

Modal Instance Sampling • In statistics, the mode is the most frequently occurring value in a distribution. In sampling, when we do a modal instance sample, we are sampling the most frequent case, or the "typical" case

Expert Sampling Expert sampling involves the assembling of a sample of persons with known or demonstrable experience and expertise in some area

Quota Sampling Select people nonrandomly according to some fixed quota. There are two types of quota sampling: proportional and non proportional. In proportional quota sampling you want to represent the major characteristics of the population by sampling a proportional amount of each.

Heterogeneity Sampling In order to get all of the ideas, and especially the "outlier" or unusual ones, we have to include a broad and diverse range of participants. Heterogeneity sampling is, in this sense, almost the opposite of modal instance sampling

Snowball • Begin by identifying someone who meets the criteria for inclusion in your study. You then ask them to recommend others who they may know who also meet the criteria. Although this method would hardly lead to representative samples, there are times when it may be the best method available. Snowball sampling is especially useful when you are trying to reach populations that are inaccessible or hard to find

Accidental, Haphazard or Convenience Sampling In clinical practice, we might use clients who are available to us as our sample. In many research contexts, we sample simply by asking for volunteers. Clearly, the problem with all of these types of samples is that we have no evidence that they are representative of the populations we're interested in generalizing to and in many cases we would clearly suspect that they are not

Morning is the sample of the day

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