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Information about MECH500

Published on May 2, 2008

Author: Kestrel


MECH 500: Bionic Implants and Devices:  MECH 500: Bionic Implants and Devices Sumitra Rajagopalan Office Hours: 5pm – 5:30 pm Mondays 4 pm- 5pm Fridays Bionic Implants & Devices: Overview:  Bionic Implants & Devices: Overview Layout of Course Evaluation & Expectations What is the course really about? Course Prologue Course Layout:  Course Layout Basic Notions in Medical Devices Functional Biomaterials for Bionic Implants Design of Soft-Tissue vs. Hard Tissue Implants Implant Surfaces and Interfaces Bioactive and Bioresponsive Implants Functional Tissue Engineering and Bioartificial Organs Bioelectrodes, Artificial Muscles and Neuroprosthetics Brain-Machine Interface and Cortical Prosthetics Implantable Devices for Minimally-Invasive Surgery Biosensors, Bioelectronics, Closed-Loop Management Getting Medical Device to Market: The Regulatory Environment Introducing Bioastronautical Engineering Course Evaluation:  Course Evaluation Class Participation: 15% Critical Review of Article(s) OR Case Study #1: 20% (Assigned) Third week of September, due early November Case Study # 2: 25% (Assigned or Chosen) Third week of October, due at the end of semester Take-Home Exam (5 questions): 40% December 1st, due December 10th What you will get out of the course::  What you will get out of the course: A broad, comprehensive overview of the field Study the human body from a materials/mechanical engineering perspective Understand and appreciate differences between living and man-made materials and structures Custom-design materials and structures to suit biological function : Biomimicry Design appropriate material surface and interface Identify optimal control & feedback system for implant Understand and appreciate factors governing behaviour in-vivo Basic design of biosensors and bioelectronic implants including Bio-mems and nems Getting medical device to market Apply knowledge of human factors engineering to extreme enviroments: outer space Project ideas for Honour’s, M.Sc/PhD thesis Learn the State-of-the-Art in the Field as well as Future Prospects So, what is this course really about?:  So, what is this course really about? Medical Devices :A Multidisciplinary Enterprise:  Life Sciences Physical Sciences Engineering Medical Devices :A Multidisciplinary Enterprise biology, physiology, biochemistry, immunology chemistry, physics, materials, mathematics electronics, image processing, mechanics, BIOMATERIALS BIOIMAGING BIONICS BIOMECHANICS BIOINSTRUMENTATION What is a Medical Device?:  What is a Medical Device? "an instrument, apparatus, implement, machine, contrivance, implant, in vitro reagent, or other similar or related article, including a component part, or accessory which is: recognized in the official National Formulary, or the United States Pharmacopoeia, or any supplement to them, intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of disease, in man or other animals, or intended to affect the structure or any function of the body of man or other animals, and which does not achieve any of it's primary intended purposes through chemical action within or on the body of man or other animals and which is not dependent upon being metabolized for the achievement of any of its primary intended purposes." Why Bionic ?:  Why Bionic ? 1976 1973 1990 2000 Bionics: Inspired by Nature:  Bionics: Inspired by Nature Coined by Jack Steeles of the U.S. Air Force in 1960 Studying Nature from an Engineering/ Design Perspective Extracting Structural, Design Paradigms. Adopting these paradigms to solve a range of engineering problems. Other names: Biomimicry,Biomimetics Bionic Implant & Device:  Bionic Implant & Device Implant that mimics – as far as possible – the structure AND function of the body part it replaces. Interacts with the human body in a bidirectional fashion Examples of Bionic Devices: Artificial Heart, Artificial Muscle, Cochlear Implant, Bioelectrodes, Mechanoactive Cartilage Towards seamless integration of implant with physiological environment Closed-loop system : Example of artificial pancreas. Living vs. Man-Made: Reflections:  Living vs. Man-Made: Reflections Living Materials, Structures and Machines:  Living Materials, Structures and Machines Multifunctional Materials Heirarchical, built through self-assembly Ordered, patterned, nano-structured Graded properties and functions throughout structure Seamless integration of materials and structures of varying properties Control & feedback integrated into structure Adaptive 3Rs: renewing, repairing, replicating FORM FOLLOWS FUNCTION FORM FITS FUNCTION FORM FITS FUNCTION: Reflection:  FORM FITS FUNCTION: Reflection Cartilage? Muscle? Bone? Skin? Anatomy of an Implant: Design & Fabrication Considerations:  Anatomy of an Implant: Design & Fabrication Considerations Biomaterial Bulk Structure Interface Implant Anchoring Sterilisation Method Power Issues in Implant Design Wireless Monitoring of Implant Biomaterials:  Biomaterials Material intended for implanting in human body Smart Materials: Bridging Materials to Life:  Smart Materials: Bridging Materials to Life Shape-memory foams Shape-memory alloys Polyelectolyte Hydrogels Piezoelectric Ceramics Electroactive Polymers Self-healing composites Supramolecular Chemistry Bionic Devices: Behaviour in-vivo:  Bionic Devices: Behaviour in-vivo Biocompatibility/Cytotoxicity Ability to function in-vivo with no adverse immune reaction Biodegradability Break-down of biomaterial through action of body enzymes into non-toxic byproducts. Biostability Resistant to break-down in the human body Biofunctionality Functions as structure intended to replace Inflammation & Immune System: Host Response :  Inflammation & Immune System: Host Response Inflammation occurs through foreign body response, movement of implant Protein layer formed on implant surface Even "inert" materials cause inflammation Inflammation reaction can adversely affect both patient & the functioning of implant Engineered biological tissue can cause adverse immune reaction Still empirical Solution? Surface Engineering:  Solution? Surface Engineering Biorecognisable implant surface Designing templates with cell-adhesion molecules Micro- and nano-texturing of surface Porous Structures : Why? Drug-eluting surfaces Functional Tissue Engineering:  Functional Tissue Engineering Engineering Living Tissue on Synthetic Scaffolds Scaffolds: porous, biodegradable, mimic the extracellular matrix Several parameters at play : ? Role of Mechanical Engineering: Develop mathematical models to describe tissue growth on scaffolds through these parameters What’s the difference between tissue engineering and functional tissue engineering? Boccafoschi, F et al. Biomaterials 26 (2005) 7410–7417 Interface with Excitable Tissue: Toward Neuromuscular Prosthetics:  Interface with Excitable Tissue: Toward Neuromuscular Prosthetics Excitable Tissue:Nerve, Muscle Bioelectronic Devices are either stimulate/record biosignals (or both) Electronic Implant consists of Power Source Controller Stimulator Electrode Used in a wide range of pathologies: spinal cord injuries, parkinson’s disease, epilepsy, stroke etc. Nerve-electrode interface remains the weakest link Study of bioelectric phenomena crucial to developing biocompatible electronic implants. Notions in Bioelectricity:  Notions in Bioelectricity Equivalent circuits used to model intefacial/ bioelectric phenomena Impedance Analysis used to calculate parameters affecting charge transfer from device-tissue Capacitance Inductance Resistance Models derived used to design medical instruments, biosensors and other bionic devices Zhu, F., Leonard,.E Levin,. N Physiol. Meas. 26 (2005) S133–S143 Wrap-up: Points to Remember:  Wrap-up: Points to Remember Highly multidisciplinary field drawing in on chemistry, biology, physiology, mechanics, electronics …. Unlike the man-made world, Nature SEAMLESSLY integrates different components and functions into a working unit. Biological materials vastly differ from man-made materials and that has to bet aken into account when designing implants Bionic Implants emerge ONLY in response to a clinical PULL (need) Bionic Implants to be designed with Clinical and Market Realities in mind. Role of Mechanical Engineer: Interfacing with multiple disciplines, interacting with multiple professionals. Carbon Nanotube Sheets for use as Artificial Muscles: Discussion Questions:  Carbon Nanotube Sheets for use as Artificial Muscles: Discussion Questions Differing requirements for robotic vs. prosthetic applications What are the advantages of carbon nanotubes? What are their drawbacks? Predict behaviour in-vivo Follow-up to this work?

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