Masahiro Satake session 6

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Information about Masahiro Satake session 6
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Published on October 9, 2007

Author: Nivedi

Source: authorstream.com

Lookback study for transfusion-related HBV infection in Japan:  Lookback study for transfusion-related HBV infection in Japan Tokyo Metropolitan Red Cross Blood Center Masahiro Satake Slide2:  Aliquots from all donations have been stored since 1997. When necessary, each aliquot was investigated using individual donation-NAT (ID-NAT). Subjects for the study : converters for HBs-Ag, HBc-Ab, HCV-Ab, HIV-Ab, screening NAT for HBV, HCV or HIV during April 1999 and February 2005 Lookback study in Japan Slide3:  ID-NAT results in repository tubes from seroconverted or NAT-converted donors (‘99 April ~ ’05 February) No. of HBV ID-NAT positive but pool-NAT negative donors estimated by lookback study:  No. of HBV ID-NAT positive but pool-NAT negative donors estimated by lookback study These donations do not directly relate to infectivity. Slide5:  The infectivity of HBV-ID-NAT positive components No. of ID-NAT positive donation    267 No. of components released 321   transfused・・・・・・・・・・・   discarded・・・・・・・・・・・   unknown・・・・・・・・・・・ Outcome of transfused patients(191 reports available )   HBs-Ag conversion   HBV-DNA conversion   HBs-Ab conversion   positive, but no information before transfusion 7   markers not changed   dead   discharged etc. 293 16 12 6 2 3 60 99 14 Slide6:  HBV infected Undetermined No change others 11 7 60 115 Infectious risk when transfused with ID-NAT positive blood 11/78~18 /78 The infectivity of HBV-ID NAT-positive components 6~10 HBV infections per year Slide7:  Infectivity of HBV ID-NAT positive components Infectivity of W.P. component is 13 times as high as that from chronic carrier. Implicated components :  Implicated components Established cases for HBV infection Disorders of patients:  Established cases for HBV infection Disorders of patients hematologic malignancy 2 gastric cancer 2 dissecting aortic aneurysm 1 shock due to multiple trauma 1 rheumatoid arthritis 1 unknown 4 ID-NAT in repository tubes --- voluntarily reported HBV cases ---:  ID-NAT in repository tubes --- voluntarily reported HBV cases --- Slide11:  The risk of HBV infection under current screening algorism including 50p-NAT system Lookback study for HCV and HIV:  Lookback study for HCV and HIV Seroconversion possibly due to nonspecific reaction was also subjected to lookback study. Slide13:  Estimates for the Occurrence of Transfusion-Transmitted Viral Diseases in Japan  HBV   HBV+ donation detectable only by ID-NAT : 1 / 150,000 11~15 infection cases per year    (1 infection / 3.6~5.4 x 105 components)  HCV (difficult to estimate)   HCV+ donation detectable only by ID-NAT : 1 / 24 million (1 component / 4 years)  HIV (difficult to estimate)    HIV+ donation detectable only by ID-NAT : 1 / 12 million (1 component / 2 years)

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