Published on February 21, 2014
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Treatment challenges • • • • • • • Acne venenata Nodulocystic acne Acne fulminans Acne conglobata Predominant closed comedones Nodular lesion Cysts of acne
• Preventing Early Acne Scars
• • • • Dermaplaning (before peeling) Chemical Peels Intense Pulsed Light (IPL) Skin Lifting
Feature Challenges • • • Life style -( look concern ) Acne Venenata (cosmetics, environmental) Drug resistance
How can one class of drugs have such a wide range of seemingly unrelated activities?
The clinical spectrum of retinoids
Retinoids available • • • • • Tretinoin Adapalene Tazarotene Alitretinoin Bexarotene
Topical Agents available for Acne • • • • • • • Tretinoin Adapalene Tazarotene Isotretinoin Motretinide Retinaldehyde Retinoyl –beta glucuronide
Topical retinoids in Acne Topical Retinoids Have Multiple Anti-Acne Actions – Inhibit the formation and reduce the number of microcomedo – Reduce mature comedones – Reduce inflammatory lesions – Promote normal desquamation of follicular epithelium – Anti-inflammatory action – Likely to enhance penetration of other drugs – Likely to maintain remission of acne by inhibiting microcomedo formation, thus preventing new lesions
“In dermatology, retinoids are the most exciting and important pharmacological agents in light of their large presence on the therapeutic scene. If no more retinoids were added to the inventory, clinicians would still be busy for decades, searching for a new therapeutic applications in diverse areas of clinical medicine” - Dr. Albert M. Kligman, Philadelphia August 1998
Introduction • It is a common inflammatory condition of pilosebaceous unit • 90% of adolescent suffer from it during their life time • Cause is multifactorial- abnormal keratinization, P.acnes, genetics, hormones, environment • It produces wide variants acne • Many topical and oral medications are effective, but selection of appropriate medication /procedure is effective
Management of Acne THANK YOU
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