67 %
33 %
Information about Leishmania

Published on December 23, 2007

Author: Nevada

Source: authorstream.com

Fun with Flagellated Friends:  Fun with Flagellated Friends Leishmania – Life cycle and social impact Vector – The Female Sandfly:  Vector – The Female Sandfly Reservoir Hosts:  Reservoir Hosts Foxes, Jackals, Rodents, Wolves, Chickens, Horses And most importantly-- DOGS Two Life-cycle stages:  Two Life-cycle stages Promastigote -elongated, with flagella (10-20 µm long) -occur extracellularly in the insect midgut -motile Amastigote -round (3-7 µm diameter) -occurs intracellularly, during mammalian stage -nonmotile The Blood Meal (fly becomes vector):  The Blood Meal (fly becomes vector) Female sandfly bites a host (usually a nonhuman animal), intakes amastigotes through proboscis. Amastigotes reproduce via binary fission and transform in the sandfly’s midgut into promastigotes. How do promastigotes get from the gut back to the proboscis? Development Inside the Sandfly:  Development Inside the Sandfly Repeated division blocks the fly gut, resulting in travel forward into the pharynx and blockage of the sucking apparatus Or Chitinolytic enzymes damage the fly cardiac valve, allowing for reverse flow into proboscis Human Infection (AKA where did I put my insect repellent?):  Human Infection (AKA where did I put my insect repellent?) Macrophage Lysis:  Macrophage Lysis Macrophage defenses:  Macrophage defenses Oxidative burst peroxide (H2O2), superoxide anion (O2-) Acidification Enzyme Digestion Intracellular Survival:  Intracellular Survival Leishmania defense mechanisms:  Leishmania defense mechanisms Produces enzymes to neutralize the oxidative burst of the macrophage. Proton pump to keep the intracellular pH close to neutral. Surface glycoproteins that degrade lysosomal enzymes. Inactivation of oxidative burst products via enzyme action:  Inactivation of oxidative burst products via enzyme action Superoxide dismutase O2- + O2- + 2H+  O2 + H2O2 Catalase or trypanothione peroxidase H2O2 + H2O2  O2 + 2H2O Surface glycoproteins:  Surface glycoproteins LPG – inhibits oxidative burst; mediates attachment of promastigotes to gut wall. gp63 – degrades lysosomal enzymes Cutaneous Leishmaniasis:  Cutaneous Leishmaniasis Mucocutaneous Leishmaniasis:  Mucocutaneous Leishmaniasis Visceral Leishmaniasis:  Visceral Leishmaniasis Global Status:  Global Status

Add a comment

Related presentations

Related pages

Leishmaniose – Wikipedia

Es gibt viele Krankheitsbilder, die der geografischen Verbreitung der jeweiligen Leishmania-Arten zuzuordnen sind. Sie reichen vom lokal begrenzten, oft ...
Read more

Leishmanien – Wikipedia

Als Leishmanien (Leishmania, nach William Boog Leishman benannt) bezeichnet man eine Gattung von geißeltragenden Protozoen, die sich im Blut in ...
Read more

Leishmanien - DocCheck Flexikon

Leishmania panamensis; Leishmania tropica; Die Übergänge sind fließend, eine genaue taxonomische Einteilung bisher noch nicht abgeschlossen. 4 Klinik.
Read more

Leishmania - Wikipedia

Leishmania / l iː ʃ ˈ m eɪ n ɪ ə / is a genus of trypanosomes that are responsible for the disease leishmaniasis. They are spread by ...
Read more

Leishmaniose beim Hund - Symptome, Behandlung und Therapie

Leishmanien oder auch Leishmania subspecies existieren vor allem in Südeuropa zum Beispiel in Spanien, Portugal und Griechenland, den Tropen, ...
Read more

Leishmaniasis - Wikipedia

Leishmaniasis, also spelled leishmaniosis, is a disease caused by protozoan parasites of the genus Leishmania and spread by the bite of certain ...
Read more

Leishmaniose: Ursache, Symptome und Therapie - NetDoktor.de

Leishmaniose-Form. befällt. Leishmanien-Spezies. Kutane Leishmaniose der „Alten Welt“ (Orientbeule) Haut. Leishmania tropica. Kutane Leishmaniose der ...
Read more


... erkranken an Leishmaniose. Der Erreger Leishmania infantum der Kala-azar infantil, und der Leishmaniose bei den HIV-Patienten ist der gleiche, ...
Read more

Leishmania | definition of Leishmania by Medical dictionary

Leishmania [lēsh-ma´ne-ah] a genus of protozoa comprising parasites of worldwide distribution, several species of which are pathogenic for humans. All ...
Read more

Leishmaniose - DocCheck Flexikon

1 Definition. Leishmaniosen sind eine Gruppe von subtropischen und tropischen Infektionskrankheiten, die durch Erreger der Spezies Leishmania ausgelöst ...
Read more