lecture01 1

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Information about lecture01 1

Published on October 15, 2007

Author: Gourangi

Source: authorstream.com

Slide1:  August 28th, 2007 Chem 547 Supramolecular Chemistry, Lecture #1 History, Definitions & Biological Inspiration Slide2:  What is supramolecular chemistry? Where did it come from? Why does it deserve to be a field of study on its own? • the study on non-covalent forces and the structures created by these forces: “chemistry beyond the molecule” • inspired from biology and built on the shoulders of synthetic organic chemistry and inorganic coordination chemistry • the next logical step in synthetic chemistry; understanding and interfacing with the biological world, nanotechnology, and nanomaterials Slide3:  Emil Fischer: The Lock & Key 1890: Recognized even before molecular structure was well understood that shape matters. In order for two species to interact in a specific fashion, they must have complementary shape & chemistry like a key fitting into a lock. Wins Nobel Prize in 1902. Slide4:  1987 Nobel Prize 1987 Nobel prize in chemistry goes to: * Donald J. Cram (1919-2001), UCLA, USA * Jean-Marie Lehn (1939-), U. Louis Pasteur, France * Charles J. Pedersen (1904-1989), Du Pont, USA “for their development and use of molecules with structure-specific interactions of high selectivity” http://www.nobel.se/chemistry/laureates/1987/index.html Slide5:  Charles J. Pedersen: Crown Ethers Dibenzo-18-Crown-6 Slide6:  Donald J. Cram: Pre-organization “Spherand” - preorganized binding site Selectivity for Li+ > Na+ >> K+ Q: What does he mean by preorganized? Slide7:  Donald J. Cram • Synthesized a huge series of increasingly complicated host-guest systems that bind molecules instead of just ions and eventually emulate an enzyme catalytic site. • Introduced the idea of a “carcerand” - synthetic molecular (jail) cells. • Primary contribution is to show how important pre-organization is to binding strength. • Shows the application of some hosts for practical application: resolution of racemic mixtures Slide8:  Jean-Marie Lehn [2.2.2] Cryptate K+ Slide9:  Jean-Marie Lehn • Introduced “Cryptands” - bicyclic hosts for binding ions • Hosts with multiple binding sites • Popularized the idea of self-assembly and produced some of the first good synthetic examples • Broadened peoples perspectives on what supramolecular chemistry is and to what it may lead the way Slide10:  Structures with multiple binding sites Slide11:  = Trefoil Molecular Knot

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