Published on October 25, 2013
Toxicological Risk Assessment An initiative of 24 October 2013 - UCL - Brussels (Woluwe) 1
Namur Nanosafety Centre University of Namur Dr Christelle Saout Senior scientist Pr Stéphane Lucas Director of NARILIS
Fields of expertise Fields of expertise • Nanomaterial (NM) physicochemical characterisation: pristine forms, dispersions, complex matrices • NM fate and biodistribution studies at cellular and organ levels • Assessment of NM potential toxicity: in vitro & in vivo testing following OECD guidelines • Metrology, cross validation studies for regulatory purposes: validated supplier of EC-JRC IRMM • Animal whole-body exposure to standardized airborne aerosols: local and systemic impacts, biopersistence • Heamocompatibility of NMs • Toxicity mechanistic studies • Nanomaterial regulation: OECD WPMN, EC DG Consumers & Health, GAARN- European Chemical Agency, BE Superior Health council 3
Industrial targets Industrial applications fields Potentially, all industrial sectors involved nanotechnologies • NM manufacturers • Paint & coating • Construction • Transport • Cosmetic • Food • Biomedical and health • Electronics • Aerospace •… 4
Applied research projects in Nanotoxicology Ongoing projects QualityNano : A pan-European Infrastructure Project for quality in nanomaterials safety testing. Joint Research and Networking Activities and provision of Transnational Access. (7 M€, 2011-14, INFRASTRUCTURE-2010-1-262163). http://www.qualitynano.eu NANOVALID: Large scale integrated project: Development of reference methods for hazard identification, risk assessment and LCA of engineered nanomaterials (7 M€, 2011-14, NMP4-LA-2011-263147). http://www.nanovalid.eu NANoREG: Large scale integrated project: Regulory testing of Nanotechnology The approach of NANoREG will provide answers to Society, Industry and the National Regulation and Legislation Authorities (48 M€, 2013-16, NMP4-LA2013, 310584). http://www.nanoreg.eu Closed projects Program of Excellence NANOTOXICO n°516252: Coordinator : Unamur–(Jan 2006 to Dec 2012) – Total Budget 10 M€ co-sponsored by DGO6-SPW & Unamur. NANOPOLYMERES project: n°DG5/MR-RB/2007/nano1. Coordinator: ISP- Nov. 2007 to June 2008) – Total Budget : 32.000,00 €. Silicalloy project: Convention n°6144 MECATECH Pole. Coordinator : De LEUZE Brussels – s.a. –Jan. 2009 to June 2013)–Total Budget 1.2 M€ Oct 24, 2013 5
Special equipments NM physicochemical characterisation • 2 MeV Tandetron linear accelerator (Altaïs) for NM-core chemical characterisation • Field Emission Gun - Scanning Electron Microscope JSM7500F /Jeol (resolution 0.6 nm) with EDX detector for morphology and global chemical composition • CPS 24000 Disc Centrifuge for nanoparticle size analysis • BET for porosity evaluation • XRD for phase and crystallinity evaluation 6
Special equipements NM toxicity assessment In vivo/ ex vivo testing • Impact-R®, PFA-100®, light transmission aggregometry, electron microscopy, KC-10®, cTGT for NM impact on blood • Whole body inhalation exposure models for biodistribution and biopersistence studies In vitro testing • Cell culture platforms – Tissue engineering - Young vs Elderly • Confocal microscopy (Leica TCS SP5) for cellular uptake and DNA damage studies • Gene expression profiling and proteomic platforms for toxicity screening 7
Services provided to companies Adapted to the demand • Physicochemical characterisation: size distribution, shape, surface properties (pristine form, complex matrices) • NM release studies – Identification of potential exposure • NM solubility • NM transport /crossing through biological barriers • Toxicity screening testings – safe by design strategy • … 8
Training proposals to companies ITEMS • Selection of best and most appropriate analytical technique for NM investigation • Training about in vivo and in vitro toxicity assessment • On site NM worker exposure measurements • Best NM manipulation practice • Origin of NM generation as byproduct for vacuum based technologies • … 9
Contacts University of Namur Namur Nanosafety Centre Rue de Bruxelles, 61 5000 Namur http://www.narilis.be/technological-facilities/namur-nanosafety-center Pr Stéphane Lucas Director of Narilis– Characterisation studies email@example.com +32 81 72 55 28 or (54 81) Dr Christelle Saout Senior scientist– in vitro studies firstname.lastname@example.org 32 81 72 57 13 Dr Olivier Toussaint Senior FNRS research associate – In vitro studies email@example.com +32 81 21 54 87 Pr Jean-Michel Dogné Director of the Pharmacy Dpt.– In vivo and hemocompatibility studies firstname.lastname@example.org +32 81 72 57 13 10
Lab'InSight du 24.10.2013, ... (NNC) (UNamur) ... Labinsight "Toxicological Risk Assessment" UNamur by Réseau LIEU.
Here are the top 24 Nnc profiles on LinkedIn. Get all the articles, experts, jobs, and insights you need. LinkedIn Home What is LinkedIn? Join Today
Toxicological Risk Assessment ... 3:00 Lab' Presentation (videos, skills, equipment, etc.) of : ... The lab'InSight concept
Labinsight "toxicological Risk Assessment" ULB ... Risk Assessment Presentation ... Labinsight "Toxicological Risk Assessment" UNamur ...