Introduction to Articualate Labs - Prepared for SXSW '14

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Information about Introduction to Articualate Labs - Prepared for SXSW '14
Health & Medicine

Published on March 11, 2014

Author: joshrabinowitz


KneeStimTM Wearable, Personalized, Dynamic Medical Devices for Mobile Rehabilitation South by Southwest 2014

Knee Joint Rehabilitation Market Pre-Surgical Dysfunction • 30M patients (9.5% US population) w/ evidence of knee osteoarthritis • 11M patients symptomatic, seeking treatment • Incidence increasing with age & obesity 1994 Post-Surgical Rehabilitation • US, 2011: 730,000 replacements, 55,000 revisions • $9B annual cost • Procedure volume growing @ 8%/yr. • 2M replacements/yr. by 2020

Limitations of Existing Treatments $5B Pre-Surgical Market Current Treatments Drawbacks/Adverse Events OTC remedies (Chondroitin) Headache, diarrhea, vomiting, swelling of knee OTC Acetaminophen Liver toxicity & limited pain relief NSAIDs Stomach discomfort, gastrointestinal bleeding Narcotics Addiction, constipation, drug-drug interactions Hyaluronic Acid Injections Risk of infection and limited duration Steroid Injections Atrophy and limited term of benefit Unloader Knee Brace Doesn’t address atrophy, cumbersome, compliance

KneeStim™ Mobile Rehabilitation Solution Stimulates quadriceps muscles during everyday movements Features • Differential muscle stimulation based on joint state • Real-time reaction to movement • Kinematic data collection • Light, form-fitting, comfortable Potential Benefits • Re-strengthened and re-educated quadriceps • Accelerated rehabilitation • Reduced rehabilitation costs • Improved functional outcomes

Unmet Needs in Rehab Market Orthopedic Surgeons ● Use data to document treatment necessity ● Help patients on waiting list Hospitals & Clinics ● Preserve margin on treatment ● Improve procedure outcomes ● Monitor patients, gain data with fewer office visits Physical Therapists ● Spend time on issues more complex than building strength ● Get feedback over time on patient's physical improvement All Improve rehabilitation Accumulate data on progress Save time and money

Proven Team Corporate Office 3 Concord Ave Suite #43 Cambridge, MA 01238 P: (617) 714-5125 Research Labs Austin, TX 78704 P: (512) 366-3063 Rick Pierce, Chief Executive Officer Javelin Pharmaceuticals (NYSE amex: JAV) sold to Hospira (01/07/10), GlycoGenesys (NASDAQ: GLGS), SafeScience (NASDAQ: SAFS), Lehman Brothers, Merrill Lynch Herbie Kirn, Chief Science Office & Co-Founder Founder, Jam Technologies; Senior Systems Engineer for GM and Chrysler advanced research facilities Josh Rabinowitz, Chief Operating Officer & Co-Founder Grant writing, research, policy analysis, communications Gavan Goss, Chief Financial Officer CFO, Dell Financial Services and Citigroup Finance; M&A Barbara Rohan, Gov’t Affairs, Public Policy & Reimbursement* VP, Gov’t Affairs, Public Policy & Reimbursement - Smith & Nephew Janie Gentry Bates, Senior Marketing Strategist* VP Marketing - Smith & Nephew Mary Kelly, Senior Reimbursement Specialist* Pfizer, Amgen, Smith & Nephew, Genzyme Bio-Surgery Marco Valez-Duran, Clinical, Regulatory & Quality* VP, Clinical, Regulatory, and Quality – Smith & Nephew * = Contractor/Consultant

Thank you Josh Rabinowitz, Co-Founder & COO O: (512) 366-3063 M: (248) 408-1503

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