Innovation For Health by DSM Chief Innovation Officer

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Information about Innovation For Health by DSM Chief Innovation Officer
Health & Medicine

Published on February 20, 2014

Author: dsmcompany


Future proof Healthcare through innovation? Approaches to address Health & Wealth in our society Rob van Leen Chief Innovation Officer, Royal DSM Boegbeeld Life Science & Health February 2014

Topsector Life Sciences & Health 1

Regiegroep Life Sciences & Health Topsector vision: Health and wealth for society and economy Vision Society QUALITY OF LIFE > improve QUALITY OF LIFE of patients > increase PRODUCTIVITY within and beyond healthcare Source: topsectorplan; cahier no. IV PRODUCTIVITY LIFE SCIENCES & HEALTH > support the AFFORDABILITY of healthcare AFFORDABILITY BUSINESS Wealth > create BUSINESS VALUE in the Netherlands Economy Health The topsector envisions a thriving Dutch Life Sciences & Health sector that develops innovative health solutions based on scientific excellence that: 2

Regiegroep Life Sciences & Health Three objectives which together contribute to affordable, high-quality healthcare PREVENTION CURE CARE 1. Maintain health, prevent healthcare 2. Maximize effect, minimize trauma 3. Manage disease extramurally 3

Regiegroep Life Sciences & Health LSH Roadmaps • Molecular Diagnostics • Imaging and image guided therapies • Home care and self-management • Regenerative medicine • Pharmacotherapy • One health • Specialized nutrition, health and disease • Health technology assessment & quality of life • Enabling technologies & infrastructure • Solutions to neglected diseases 4

Regiegroep Life Sciences & Health Efficient valorization requires 7 critical success factors IDEA GENERATION DEVELOPMENT Increase the number of promising ideas Accelerate the development process and heighten the chance of success 1 2 APPLICATION Accelerate and broaden effective application (nationally and internationally) Demanding Dutch market and patients, a portal into Europe/ the rest of the World Optimized legal and regulatory landscape 3Sufficient well educated, entrepreneurial people 4 Good accessibility to the right capital 5 Strong, accessible (fundamental) knowledge base 6 Shared public-private innovation infrastructure The 7 Netherlands as one self-organized Life Sciences & Health sector 5


Regiegroep Life Sciences & Health Transition from TopInstitutes BMM, CTMM, TiP & NGI • Transition period is necessary: Identify ‘pearls’ and continue support, safeguard data infrastructure and valorization initiatives. • Capitalize on built up PPS expertise and networks to attract EU money (Horizon 2020, in e.g. IMI-2) • Strenghten operational capacity of the Topsector (TKI-Office) • Budget made available by EZ – efforts to include VWS and OCW 7

Meer informatie: 8

@DSM > 23K People: Living our Passion

People Health Food & Nutrition Security Sustainable Innovation Themes  a Sustainable Company Energy Security Planet Sustainable Manufacturing/ Raw Materials Profit

Building an intrinsically innovative company 20% Innovation Sales 2015 @ ~5% higher Gross Margins Top Quartile McKinsey Innovation Benchmark 2012 €1B Disruptive Platforms, 2020

Accelerating and supporting innovation DSM Innovation Center New Business Development Accelerators EBA Biomedical Excellence in Innovation EBA Bio-based Products & Services CTO Office EBA Advanced Surfaces Licensing Business Incubator Venturing

Why do we need Open Innovation? DSM 99.999996% of world population outside DSM! Networks needed!

Open Innovation in biomedical materials Joint R&D Licensing In Joint Business Developments Actamax Joint-venture Venturing Spin in Acquisitions Divestments R&D services Licensing Out Spin out/off Device design; Exclusive material developments Scientific Advisory Board & other Consultants

DSM Biomedical materials improve over 4.4 million people’s lives, every day.

A world class portfolio of biomedical materials Silicone hydrogels Natural Materials Biomedical polyurethanes Mechanical Devices UHMWPE biomaterials Drug delivery Coatings ECMs Polymers & Metals Bio Commercialization

Escalation of healthcare costs Cost per intervention Healthy Life style Food & Sport Medication & non-invasive treatment Surgery Restore Repair Maintain Health Total disease cost Nurture Health curative preventive Severity / Invasiveness of intervention Page

Micronutrient intake in Western countries Germany United States United Kingdom The Netherlands Source: Troesch et al BJN 2012

Example vitamin D: the inadequate status impacts a number of body functions Classical role of vitamin D: bone health normal • Improves bone mineral density through calcium absorption and deposition • Necessary to prevent rickets & osteomalacia Emerging health benefits of vitamin D • Muscle - Reduces risk of falling by improving muscle strength • Immunity - Strengthens the immune system - Reduces risk of multiple sclerosis and diabetes type I and II • Cardiovascular - Lowers blood pressure • Cancer - Inhibits cell proliferation osteoporotic

The health continuum : example of the knee HALS-UH Restore Repair Maintain Health Nurture Health Page 20

To conclude Prevention, Cure and Care, together with Diagnostics all need integrated attention to improve peoples lives and get a hold on healthcare costs Open Innovation and Collaboration between all parts of the “health value chain” is essential to accomplish breakthrough solutions Topsector LSH increasingly integrates, facilitates and stimulates the complete public private innovation infrastructure with all parties involved DSM has competences in both Life Sciences and Materials Sciences which contribute to a brighter life for people today and generations to come

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