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INMHA 050818 en

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Travel-Nature

Published on March 10, 2008

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Slide2:  CIHR’s 13 Institutes Four Research Pillars of CIHR:  Four Research Pillars of CIHR Biomedical Clinical Health services and health systems Health of populations, societal and cultural dimensions of health, and environmental influences on health CIHR Budget 2005-2006:  CIHR Budget 2005-2006 Canadian Institutes of Health Research:  Canadian Institutes of Health Research Institute of Neurosciences, Mental Health and Addiction CIHR-INMHA: a Canadian Experiment:  CIHR-INMHA: a Canadian Experiment Virtual institute aimed to promoting interdisciplinary approaches to the study of neuroscience, mental health, addictions and the sensory systems integration of neuroscience (including vision, hearing, communication, pain, etc.), mental health and addiction research Unique model in the world Quirion (2002) A Canadian experiment: INMHA. How to link up the brain via a virtual institute. TINS 25: 268-270 Institute Advisory Board 2004-2005:  Institute Advisory Board 2004-2005 Dr. Anthony Phillips (Chair) Dr. Kathryn Bennett Dr. Serge Brochu Dr. Yves de Koninck Ms. Judy Hills Dr. Judy Illes Mrs. Mary Jardine Dr. Alain Lesage (vice-chair) Dr. Ravi Menon Dr. Freda Miller Dr. Marlene Reimer Dr. Patrice Roy Dr. Michael Salter Dr. Eric Single Dr. Martin Steinbach Dr. Jane Stewart Dr. Donald Weaver Dr. Douglas Zochodne University of British Columbia, Vancouver BC McMaster University, Hamilton ON Université de Montréal, Montreal (Quebec) Université Laval, Quebec City (Québec) Public Representative, Toronto ON Stanford University, Palo Alto CA Public Representative, Toronte ON Université de Montréal, Montréal QC University of Western Ontario, London ON University of Toronto, Toronto ON University of Manitoba, Winnipeg MB Pfizer Canada, Montréal QC University of Toronto, Toronto ON University of Toronto, Toronto ON York University, Toronto ON Concordia University, Montréal QC Dalhousie University, Halifax NS University of Calgary, Calgary AB INMHA IAB Focus Groups :  INMHA IAB Focus Groups Ethics and Law Government Affairs and Networking Industry and biotechnology International Affairs Performance Evaluation and Budget Training and Education Voluntary Sector and Professional Organizations Clinical Research INMHA Vision:  INMHA Vision The Institute of Neurosciences, Mental Health and Addiction believes that innovative, ethically responsible research will lead to better health for all Canadians. INMHA Mission:  INMHA Mission The mission of the INMHA is : to foster excellence in innovative, ethically responsible research that increases our knowledge of the functioning and disorders of the brain and the mind, the spinal cord, the sensory and motor systems, and mental health, mental illness and all forms of addictions. To foster cutting-edge research that incorporate the four pillars of CIHR: biomedical, clinical, health services and health systems, and population health to translate this new knowledge into improved health outcomes and quality of life for all Canadians. INMHA Values:  INMHA Values INMHA: Commits to the support of excellence, scientific integrity and ethics in research that meets the highest international standards; Cultivates an understanding of the diversity of the disciplines covered by the INMHA mandate in order to expand beyond traditional approaches to research; Affirms the importance of research and knowledge translation as means of making a difference in the lives of people who are experiencing or who are at risk for the disorders and illnesses of concern to the INMHA; INMHA Values:  INMHA Values INMHA: Respects ethical, transparent and effective governance and management processes that establish the INMHA’s credibility and strengthen its organizational capacity; Acknowledges its accountability to the Governing Council of the CIHR, the Government of Canada and Canadians for the accomplishment of its mission. INMHA Strategic Goals:  INMHA Strategic Goals To accomplish its mission, the INMHA will: Promote and support excellence in peer-reviewed, internationally recognized and ethically responsible research in the domains of the Institute, including co-occurrence with other health problems and co-morbidity; Encourage trans-disciplinary research in order to facilitate knowledge transfer aimed at developing and improving health care treatments and services; Ensure the training and support of the next generation of Canadian scientists in all aspects of neurosciences, mental health, and addiction by promoting and sustaining the development of trans-disciplinary programs of research and training. INMHA Strategic Goals:  INMHA Strategic Goals To accomplish its mission, the INMHA will: Work with non governmental and volunteer health organizations, municipal governments and other interested stakeholders to reduce the discrimination and prejudices associated with neurological and sensory disorders, mental illnesses and addictions; Promote the visibility and mandate of the INMHA and its contribution through effective communication with all sectors of civil society; INMHA Strategic Goals:  INMHA Strategic Goals To accomplish its mission, the INMHA will: Work with the Government of Canada, provincial and territorial governments, members of the scientific community, non governmental and volunteer health organizations, foundations and all Canadians to ensure that sufficient human and financial resources, consistent with the burden of disease of the disorders covered by the INMHA, are made available to the Institute in order to enable it to achieve its goals. Interact with all stakeholders to identify research priorities, establish partnerships and undertake collaborative activities. Approaches Used to Develop INMHA First Strategic Plan :  Approaches Used to Develop INMHA First Strategic Plan Visits to universities and research centres across the country (>30) Two NGO meetings http://www.cihr-irsc.gc.ca/e/8586.html International visits NIH, WHO, PAHO, etc. Prioritization by IAB and Scientific Director 2001-2005 Strategic Plan Outcomes of consultations:  Outcomes of consultations INMHA Strategic Priority One:  INMHA Strategic Priority One To foster and develop a capacity for innovation in research in neurosciences, mental health and addiction Training Strategic Initiatives Early Life Events and First episodes in brain disorders Co-occurrence of brain disorders with other health problems and co-morbidity Regenerative Medicine and Nanonmedicine Nicotine addiction and tobacco abuse Emerging areas and unique opportunities Research in bioethics INMHA Strategic Priority Two:  INMHA Strategic Priority Two To pursue and sustain collaborative partnership The INMHA will: Collaborate with the Strategic Partnerships and Alliances and the Industry Program Branches of CIHR in identifying and developing potential partnerships Develop sustainable partnerships with other Institutes and with governmental organizations at the national and international levels as well as with NGOs and VHOs Collaborate and partner with NGOs and VHOs in effort aimed at advancing Advocacy, information dissemination, knowledge translation, training, leverage funding, surveillance, community support INMHA Strategic Priority Three:  INMHA Strategic Priority Three To promote linkage and exchange through structured efferts aimed at knowledge translation The INMHA has defined the following strategies: Collaborate with CIHR in developing a framework for contributing to public policies and programs that will help create an environment conducive to the development of the CIHR and its institutes Engage in structured, individual activities that promote linkage and exchange Develop a comprehensive stakeholder knowledge translation strategy INMHA Strategic Priority Four:  INMHA Strategic Priority Four To insure INMHA’s presence on the international stage The INMHA will help Canadian scientists by promoting and developing joint research and training initiatives with institutes in other countries. This strategy will enable the INMHA to: Develop and pursue collaborations international research projects and funding Promote and establish trainee exchange programs at the international level. INMHA Strategic Priority Five:  INMHA Strategic Priority Five To establish an effective organizational and operational structure The INMHA’s organizational structure and operational processes must support the efforts and endeavours of the Institute, and ensure its accountability to CIHR and its stakeholders. Three components of the strategy have been identified: Implement an effective governance, accountability and management structure and process Develop and sustain structured communication efforts aimed at informing and gaining an understanding of the health and research issues related to INMHA’s domains Develop a framework for gathering, maintaining and accessing relevant and reliable health and research information in the fields of interest to the INMHA. INMHA Institute Support Grant:  INMHA Institute Support Grant $1 million/year since 2001 Staff salaries Conference, symposia and workshops Annual Meeting Annual reports and brochures Web site (www.thebrain.mcgill.ca) IAB expenditures Travel Office rental Supplies International Activities Partnership Development INMHA Strategic Initiative Budget:  INMHA Strategic Initiative Budget INMHA Strategic Initiative Budget 2004-2005:  INMHA Strategic Initiative Budget 2004-2005 Some INMHA initiatives (2002-2005):  Some INMHA initiatives (2002-2005) Brain Star Award Strategic Training Initiative in Health Research Bridging Operating Grants Priority announcement New Emerging Team Program Strategic Initiatives Inter-institute partnerships International Collaborations Workshops and scientific meetings INMHA Strategic Priority One :  INMHA Strategic Priority One Training Grants and Salary Support Brain Star Program:  Brain Star Program To recognize the excellence of research done by trainees in all fields covered by our Institute $1,000 per award Awarded every 2 weeks Based on a research article recently published as first author in a high impact journal Cross-pillar is a plus Brain Star of the year since 2003 For more details: www.cihr-irsc.gc.ca/e/8585.html Recent Brain Star Awardees:  Recent Brain Star Awardees McMaster (Dalhousie) Hippocampal volume in early onset of depression (2004) BMC Medicine 2 :2 Cotrell (Queen’s) Prokiceticin 2 modulates the excitability of subfornical organ neurons (2004) J Neurosci. 24:2375 Thompson (Toronto) Variant of the Orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette’s syndrom comorbidity (2004) AM. J. Med. Genet. 129 B(1):69-75 Nicholls (UBC) Assessing risk of violence among male and female civil psychiatric patients: The HCR-20, PCL:SV, and VSC (2004) Behav. Sci Law 22: 127-158 Kogan (McGill) Differential impact of the FMR1 gene on visual processing in fragile X syndrome (2004) Brain 127: 591-601 Brain Star of the year:  Brain Star of the year 2003 Michelle Aarts and Yitao Liu Aarts M., Liu Y., Bessoh S., Arundine M., Gurd J., Wang Y.T., Salter M. (2002) Brain damage by perturbing NMDA receptor PSD-95 protein interactions Science 298:846-850. 2004 Jeffrey Coull Coull J., Boudreau D., Bachand K. Prescott S.A., Nault F., De Koninck P.Y. (2003) Transynaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424:938-942 Strategic Training Initiative in Health Research:  Strategic Training Initiative in Health Research First competition 2001 CIHR central and Institutes supported 51 teams funded 8 of them related to INMHA $300K per year for 6 years Cross-pillars and multi-centres favoured Strategic Training Initiative in Health Research:  Strategic Training Initiative in Health Research First Competition 2001-2002 Teams related to INMHA Cameron (Waterloo) Tobacco Research De Koninck (Laval) Neurophysics: Setting new frontiers in neurosciences with material sciences and photonics Fenster (UWO) Vascular and cerebrovascular transdisciplinary training program Houry (Toronto) Protein folding. Principles and diseases McGrath (Dalhousie) Pain in child health Reithmeier (Toronto) Structural biology of membrane proteins linked to disease Salter (Toronto) Pain research. From molecules to community Vincent (UBC) Neurobiology and behaviour Strategic Training Initiative in Health Research:  Strategic Training Initiative in Health Research Second competition 2002 Funded by each Institute INMHA received 15 LOI With internal and external (FRSQ, NAAR) partners INMHA is associated to 10 successful applications Funding for six years started in April 2003 Strategic Training Initiative in Health Research Second Competition 2001-2002:  Strategic Training Initiative in Health Research Second Competition 2001-2002 Antel (McGill) Integrated Training Program in basic and clinical aspects of neuroinflammation Chaudhuri (McGill) McGill integrative neurobehavioral training program: focus on regenerative medicine and early life events Fombonne (McGill) Training program in autism research Goldner (UBC) Building capacity in mental health and addiction services and policy research Holden (Queen’s) Transdisciplinary inter-institute training program in autism spectrum disorders Kirmayer (McGill) Culture and mental health services Meaney (McGill) Genes, environment and health training program Mishara (UQAM) Formation interdisciplinaire en recherche sur le suicide et sa prévention Selby (Toronto) Tobacco use in special populations Wilson (York) CIHR strategic training program in vision research STIHR WORKSHOP Nov. 28-29, 2005:  STIHR WORKSHOP Nov. 28-29, 2005 A STIHR Workshop will be held on Nov. 28-29, 2005 in Montreal, for all training program grants related to INMHA INMHA Salary Awards - Spring and Fall 2002 – :  INMHA Salary Awards - Spring and Fall 2002 – Doctoral Research Award (11) Post-doctoral Fellowship (8) Senior Research Fellowship (1) New Investigators (2) Clinician Scientists (2) Senior Investigator (1) INMHA Doctoral Research Award:  INMHA Doctoral Research Award Alain (Montréal) Les processus C-REM induits par stimulations vibratoires pendant le sommeil NREM Arudine (Toronto) Cellular and molecular mechanisms of secondary neurotrauma Beauchamps Étude des résultats des traitements psycho- (McGill) sociaux auprès des jeunes présentant un premier épisode de schizophrénie Bédard (Toronto) Application of virtual reality technology in assessing cognitive function in children with ADHD Brouillette (McGill) Action neuroprotectrice de l’IGF-1: Rôles des akt kinases et régulation génomique Caraiscos (Toronto) Enhancement glycine receptor function by insulin receptor-mediated pathways INMHA Doctoral Research Award:  INMHA Doctoral Research Award Ghasemlou Characterization of trkA and p75 neurotrophin (Queen’s) receptor function in sympatetic and sensory axonal growth Lefebvre (Dalhousie) Use of event-related brain potentials and standardized neuropsychological stimuli in the understanding and assessment of working memory abilities in patient following brain injury Ohayon (Toronto) Recurrent neural network models of kindling Sharif (McGill) Differential contribution of the nervous system to inflammation and joint destruction in an animal model of monoarthritis Thibeault (Laval) Rôle de la réponse immune dans le système nerveux central INMHA Fellowships:  INMHA Fellowships Henriques Kinesthetic guidance of limb movements: (Minneapolis) Kinesthetic spatial perception and its role in action Moller (Toronto) Screening for neurocognitive impairment and road safety in sleep disorders using the virtualized environment of a computerized driving simulator Powell (Dalhousie) Effects of fetal neurons and stem cell derived neurons on pre- and post-synaptic gene expression in striatum and substantia nigra Rose (Valencia) Effect of acute brain liver failure on cerebral function: Brain metabolism and signal transduction pathways Van der Werf Cortical oscillations in the healthy and disordered (McGill) brain: Studies with transcranial stimulation INMHA Senior Research Fellowships:  INMHA Senior Research Fellowships Marotta (York) Hemispatial neglect: A multidisciplinary investigation of the effect on visual perception and visually guided action INMHA New Investigators:  INMHA New Investigators Joober (McGill) Genetics of schizophrenia : From animal models to human studies Yan (Calgary) Neural mechanisms of learning-induced auditory plasticity: Role of cortical acetylcholine and corticofugal modulation INMHA Clinician scientists:  INMHA Clinician scientists Daskalakis A study of cortical inhibition and (Toronto) plasticity in schizophrenia using transcranial magnetic stimulation Dupré (McGill) Clinical and genetic study of a new form of recessive cerebellar ataxia frequently encountered in the Beauce region (Québec) and the surrounding area INMHA Senior Investigator:  INMHA Senior Investigator Szatmari (McMaster) Understanding developmental trajectories in autism INMHA Strategic Priority One :  INMHA Strategic Priority One Grant Funding and Strategic Initiatives INMHA First Two Initiatives:  INMHA First Two Initiatives IHRT Karpati et al. (McGill University) Gene Therapy for Neurological Disorders (ICR, IHDCYH, IMHA, Neuroscience Canada, Muscular Dystrophy of Canada) CAHR (IAPH/INMHA Special Project) Kirmayer et al. (McGill University) National Network for Aboriginal Mental Health Research Research in emerging areas:  Research in emerging areas Institute-specific initiatives New Emerging Team (NET) 3 to 6 independent investigators senior and junior investigators Collaborative multidisciplinary research Up to $300,000 per year for five years Research in emerging areas:  Research in emerging areas NET Research Themes for 2001-2002 Discrimination and stigma Understanding the placebo effect Neurodevelopment and early life events Computational neurosciences and artificial intelligence Neurodevelopment and early life events:  Neurodevelopment and early life events Brien (Queen’s) Fetal alcohol syndrome, oxidative stress and innovative therapies Honer (UBC) Interactions of development, early life experience, and genetic predisposition in schizophrenia Paus (McGill) Long-term consequences prenatal exposure to maternal cigarette smoking on brain structure, function and mental health in adolescence: Role of genes and environment in brain development Robaey (Montréal) Inattention, impulsiveness and restlessness in childhood: Heritability, genetics, neuropsychology and psychophysiology (KIDNET) Computational neurosciences and artificial intelligence:  Computational neurosciences and artificial intelligence Kalaska Learning task decomposition in (U de Montréal) large-scale biological and artificial neural networks McIntosh Development of integrative (U of Toronto) computational neuroscience program to understand human mental function Research in emerging areas:  Research in emerging areas NET Research Themes for 2002-2003 Discrimination and stigma (Re-issued) Understanding the placebo effect (Re-issued) Post-traumatic stress syndrome Comorbidity and co-occurrence Regenerative Medicine - Neurosciences Post traumatic stress disorder:  Post traumatic stress disorder Asmundon Understanding Risks Factors, (U of Regina) Co-morbidity, and Global Health Issues in PTSD Coupland « STRESS » Stress, Trauma (U of Alberta) and Recovery: Early Stage Studies Understanding the Placebo Effect:  Understanding the Placebo Effect Lavigne Comprendre l’effet placebo à (U de Montréal) partir d’études expérimentales et cliniques sur le sommeil et la douleur impliquant des états de vigilance altérés Regenerative Medicine _ Neuroscience:  Regenerative Medicine _ Neuroscience Weaver (UWO) In partnership with Ontario Neurotrauma Foundation Spinal Cord Injury: Discovery and development of rescue and repair strategies. Research in emerging areas:  Research in emerging areas NET Research Themes for 2003-2004 Neuroethics Downie (Dalhousie University) Neuroimaging ethics: From theory to practice Suicide Prevention targeted to Aboriginal People (with IAPH) Andersson (CIET, Ottawa) Aboriginal Community Youth Resilience Network (ACYRN): Community-led research and resources to prevent youth suicide Turecki (McGill U.) Understanding and acting on Aboriginal suicide: A new multidisciplinary research team Research in emerging areas:  Research in emerging areas NET Research Themes for Dec. 2004 Neuroethics (re-issued) Suicide prevention targeted to Aboriginal People (re-issued) Mental Health in the Work Place (with IPPH) For June 2005 Mental Health in the Work Place Research in emerging areas:  Research in emerging areas Analysis of the Canadian Health Survey on Mental Health and Well-Being (Health Services and Policy Research, Gender and Health as well as Statistics Canada, Ontario Problem Gambling Research Centre and Northern Health Research Initiative) Caron (McGill U) Le soutien social, la santé mentale et le bien-être des populations pauvres au Canada Cole (McGill U) Health services use by Canadian seniors with major depression Cox (U of Manitoba) Two population-based mental health studies using the CCHS (cycle 1.2): social phobia and problem gambling D’Arcy (U of Saskatchewan) A mental health divide? Rural-urban and intra-rural differences in mental health services Research in emerging areas:  Research in emerging areas Analysis of the Canadian Health Survey on Mental Health and Well-Being (2) Dewa (U of Toronto) Psychiatric disorders, chronic physical conditions, workplace stress and disability in the Canadian working population Fournier (U de Montréal) Troubles anxieux chez les jeunes de 15 à 24 ans : évolution, déterminants et recours aux services Lesage (U de Montréal) Utilization of services for mental health reasons- cross provincial differences in rates and determinants Newman and Thompson (U of Alberta) Prevalence and correlates of pathological gambling Patten et al. (U of Calgary) Descriptive epidemiology of major depression in the Canadian population Roman (U of Toronto) Gender issues in depression and anxiety for Canadians less than 65 years of age Research in emerging areas:  Research in emerging areas Analysis of the Canadian Health Survey on Mental Health and Well-Being (3) Rush (U of Toronto) Concurrent substance use and mental disorders in Canada: prevalence and impact on service utilization Sareen (U of Manitoba) Correlates of mental health services utilization and emotional well-being: Analysis of the CCHS survey cycle 1.2 Stewart et al. (U of Toronto) The relation between work-related factors and mental health in Canada men and women Streiner and Cairney (U of Toronto) Psychiatric disorders, associated risk factors and mental health services use among adults aged 55 and older in Canada Tempier (McGill U) General practice and mental health care: a Canadian-Australian comparative study Research in emerging areas:  Research in emerging areas Analysis of the Canadian Health Survey on Mental Health and Well-Being (4) Waraich and Streiner (UBC) Validation of administrative cases of major depressive disorder using CCHS 1.2 data Zumbo (UBC) Bias in self-reported health services utilization in the CCHS on mental health and well-being: Influences of age, gender, personal characteristics and patterns of care Research in emerging areas:  Research in emerging areas In partnership with IHSPR Vingilis (UWO) Marrying knowledge generation with knowledge diffusion and utilization:  The consortium for applied research and evaluation in mental health In partnership with IHSPR Kisely (Dalhousie U) Measuring quality in mental health services across Nova Scotia evaluation of a demonstration site Dewa (U Toronto-CAMH) Examining the effectiveness of a collaborative care model for individuals with severe mental illness In partnership with IGH Violence, Gender and Health across the lifespan Pepler (York U) Preventing violence in the lives of girls and women: A focus on relationships McMillan (McMaster U) Health impacts of violence across the lifespan. A multidisciplinary approach. Research in emerging areas:  Research in emerging areas In partnership with the Fogarty Centre of the NIH Stigma and Global Health C. Benoit (University of Victoria) Joint RFA to be re-issued in 2006 INMHA Bridging Funds:  INMHA Bridging Funds One-year operating grants for highly-rated proposals Priority Announcements March 2002 Competition (13 projects funded) September 2002 Competition (3 projects funded) March 2003 Competition (1 project funded) September 2003 (3 projects funded) March 2004 (3 projects funded) September 2004 (5 projects funded) March 2005 (6 projects funded) Majority successful in obtaining CIHR/NIH operating grants in subsequent competition (70%) INMHA Bridging Funds March 2002:  INMHA Bridging Funds March 2002 Bartha (UWO) Monitoring metabolism and tissue magnetic susceptibility during acute focal cerebral ischemia Brown (UWO) In vivo and in vitro studies of EphA3 and EphA4 signaling Carlen (Toronto) Synaptic mitochondria: Physiology and pathophysiology Cuello (McGill) Studies on the plasticity of CNS cholinergic neurons Fehlings (Toronto) Apoptosis after spinal cord injury: The role of Fas, p75NTR, and NF-kappaB Franklin (McGill) Sex steroids and depression as modulators of pain sensitivity (with IMHA) Gianoulakis (McGill) Alcoholism, central opioid activity and stress responses as a function of family history and gender INMHA Bridging Funds March 2002:  INMHA Bridging Funds March 2002 Mishra (McMaster U) Role of catecholamine regulated proteins (CRPs) in schizophrenia O’Craven Understanding the neural mechanisms of visual (U of Toronto) cognition: fMRI studies of human extrastriate cortex Peters (UWO) Procedures for image-guided neurosurgery in the deep brain Prat (U de Montréal) Functional analysis of the metalloendopeptidase NRDc Rossi (UBC) A model for regulated delivery of neuropeptides to the CNS through microglia mediated gene therapy Sullivan (Montréal) Cerebral laterality, prefrontal cortex and stress INMHA Bridging Funds September 2002:  INMHA Bridging Funds September 2002 Gratton, Meaney (McGill) Early experience and the development of the corticolimbic dopamine system Niles (McMaster) Neurotrophine induction and neuroprotection by melatotin in Parkinson’s disease Vaucher (Montreal) Modulation cholinergique du cortex visuel du rat INMHA Bridging Fund March 2003:  INMHA Bridging Fund March 2003 Antel (McGill) Cellular immune injury of human oligodendrocytes INMHA Bridging Fund September 2003:  INMHA Bridging Fund September 2003 Kerouac (Memorial U.) Regulation of orexin (hypocretin) neurons by monoaminergic and cholinergic systems Létourneau Support for women who experienced symptoms (U of Alberta) of postpartum depression Zhang (U of Toronto) Cellular mechanisms of hippocampal sharp wave and associated fast oscillations INMHA Bridging Funds March 2004:  INMHA Bridging Funds March 2004 Sarret (U de Sherbrooke) Régulation des récepteurs de la neurotensine: Implication dans le contrôle de la douleur Karim (McGill U) Towards an understanding of reconsolidation Joanisse (UWO) The brain bases of speech perception: Imaging studies of normal adults and developmentally impaired children INMHA Bridging Funds September 2004:  INMHA Bridging Funds September 2004 Fouad (U of Alberta) Combining axonal growth promoting treatments with rehabilitative training Magoski (Queens’s U) The role of calcium channel in controlling neuronal excitability Morshead (U of Toronto) Examining the function and regulation of adult mammalian neural stem cells Soja (UBC) State-dependent control of spinal interneurons Zadra (U of Montreal) Precipitating factors and psycho- physiological correlates of adult somnambulism Bridging Funds March 2005:  Bridging Funds March 2005 Allen (U. of Alberta) In-vivo magnetic resonance spectroscopic quantification of brain metabolites Chahine (U. of Laval) Modulation of nav1.7 and nav1.8 two peripheral nerve Na channels by local anesthetics and auxiliary beta-subunits Mishra (McMaster U) Role of synapsin II in schizophrenia and its regulation by typical and atypical antipsychotic drugs Poulter (U. Carleton) GABA-A receptor plasticity in response to experimental epilepsy Ross (U. of Alberta) In vivo exploration of brain connectivity in temporal lobe epilepsy Duquette (U. of Montreal) Further exploration of the mechanisms underlying motor dysfunction in antipsychotic drug-treated monkeys INMHA Four Major Strategic Initiatives:  INMHA Four Major Strategic Initiatives Nicotine Addiction and Tobacco Abuse Co-occurrence of brain disorders with other health problems and comorbidity Early Life Events and First Episodes of Brain Disorders Regenerative Medicine and Nanomedicine 1st Major Strategic Initiative:  1st Major Strategic Initiative Nicotine addiction and tobacco abuse National Summit, Ottawa, April 2002 Report on CTCRI Web site (www.ctcri.ca) RFA “Advancing the science to reduce tobacco abuse and nicotine addiction” June 2003 Partners CIHR: INMHA, ICR, IAPH, ICRH, IGH, IHDCYH National Cancer Institute, Canadian Cancer Society, Heart and Stroke Foundation, Health Canada, Canadian Lung Association, Association pulmonaire du Québec Funding in 2004 1st Major Strategic Initiative:  1st Major Strategic Initiative Nicotine addiction and tobacco abuse Two teams supported for 5 years by INMHA and many other partners (June 2004) P. Clarke (McGill U.) Nicotine addiction: Behavioral and brain mechanisms from rodents to humans P.W. McDonald (U. of Waterloo) A Pan-canadian Resource Network for Tobacco Control Research, Policy and Practice 1st Major Strategic Initiative:  1st Major Strategic Initiative Nicotine addiction and tobacco abuse Re-issued in December 2004 RFA on Research in Addiction with CTCRI, CCSA, OPGRC and other partners http://www.cihr-irsc.gc.ca/e/25700.html Tobacco Abuse and Nicotine Addiction (re-issued) and Community based research grants with CTCRI www.ctcri.ca Funding starts in 2006 2nd Major Strategic Initiative:  2nd Major Strategic Initiative Co-occurrence of brain disorders with other health problems NET Program May 2002 Consultation Workshop on September 22-23, 2005, in Ottawa to plan development of a RFA with partners in June 2006 3rd Major Strategic Initiative:  3rd Major Strategic Initiative Early Life Events and First episodes in Brain Disorders In partnership with IHDCYH Steering Committee, Halifax, October 2002 Workshop, Montréal, February 9-10, 2004 Report on the Web, Spring 2004 RFA in mid-December 2004 www.cihr-irsc.gc.ca/e/25650.html Funding for team grants to be announced in 2006 4th Major Strategic Initiative:  4th Major Strategic Initiative Regenerative Medicine and Nanomedicine (1 of 4 CIHR Large Strategic Initiatives) stem cells, nanomedicine, gene therapy, tissue engineering, rehabilitation Brain and spinal cord repair IHRT on Gene therapy (Karpati, McGill U.) NET on Spinal Cord Injury (Weaver, UWO) Vision and hearing losses Partners CIHR: INMHA, IG, ICR, ICRH, III, IMHA Canadian Genetic Diseases Network, Canadian Stroke Network, Juvenile Diabetes Research Foundation International, Heart and Stroke Foundation, NSERC, NRC, Neuroscience Canada, Stem Cell Network, Canada Space Agency, etc Nanomedicine Workshop, Feb. 2003 Annual Meeting - Nanomedicine, Feb. 2004 and March 2005 RFA in June 2003, re-issued in June 2004 and June 2005 For details: www.regenerativemedicine.ca 4th Major Strategic Initiative:  4th Major Strategic Initiative Regenerative Medicine and Nanomedicine 1st competition New Discoveries High Risk Grant (with IG) Jefferies (UBC) Delivery of therapeutics proteins across the blood-brain barrier Invention, Tools and Devices Kirby (Dalhousie) Rear anti-tip devices for manual wheelchairs: Effect of new vs conventional design on performance, user satisfaction and social participation Scott (Queen’s) KINARM - A robotic tool for objective assessment of upper limb motor function De Koninck Novel microprobes for combined optical and (U. Laval) electrical recording in vivo 4th Major Strategic Initiative:  4th Major Strategic Initiative Regenerative Medicine and Nanomedicine 5 year Team Grants 1st competitition W. Chan (U of Toronto) Quantum dot-based biomolecular imaging M. Fehlings (U of Toronto) Regenerative medicine strategies for spinal cord injury repair: Integration of stem cell biology, nanotechnology, bioengineering approaches and neurosurgical application A. Daar (U of Toronto) Regenerative Medicine: Ethical, Environmental, Economic,  Legal and Social Issues Network S. Rivest (Université Laval) Engineered bone marrow stem cells (BMSCs) for treatment of CNS injuries and diseases I. Brunette (U de Montréal) Femtosecond Laser Assisted Corneal Posterior Lamellar Transplantation with Endothelial Enhancement: Technological Developement and Socioeconomic Impact W. Stanford (U of Toronto) Stem cell fate analysis and manipulation J. Galipeau (McGill U) Cardiovascular and respiratory stem cell plasticity – CARE project. Y. de Koninck (Université Laval) Nanotools for neuropharmacology 4th Major Strategic Initiative:  4th Major Strategic Initiative Regenerative Medicine and Nanomedicine: Innovative Approaches in Health Research RFA re-issued in June 2004 and June 2005 Team Grants New Discoveries High Risks Seed Grants Funding starts in 2006 and 2007 www.cihr-irsc.gc.ca/e/22842.html INMHA Strategic Priorities Two and Four :  INMHA Strategic Priorities Two and Four Partnership and International Visibility Inter-Institute Partnerships:  Inter-Institute Partnerships Include most if not all CIHR Institutes, for example: Analysis of the Canadian Community Health Survey on Mental Health and Well-Being (IHSPR, IGH and Statistics Canada, Ontario Problem Gambling Research Centre and Northern Health Research Initiative) Gene Therapy (ICR, IHDCYH, IMHA and NeuroScience Canada and Muscular Dystrophy Association of Canada) Training Program in Aboriginal Mental Health (IAPH) Alcoholism and Gender (Gender and Health) ICE (IHSPR) Outreach Initiative for NGOs (IGH) Strategic Training Initiative in Health Research (most institutes) One-year Bridging Funds Large Strategic Initiatives National Partnerships:  National Partnerships EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health with the Royal Society of Canada and EJLB Foundation (Min Zhuo, University of Toronto) Barbara Turnbull Award with Barbara Turnbull Foundation for Spinal Cord Research and NeuroScience Canada (50,000$ added to the top grant in spinal cord research) David Kaplan, U of Toronto, 2002 Mohammad Sawan, École polytechnique, Montréal, 2003 David Bennett, U of Alberta, 2004 Canadian Tobacco Control Research Initiative /NCI RFA “Advancing the Science to Reduce Tobacco Abuse and Nicotine Addiction” National Partnerships:  National Partnerships Ontario Neurotrauma Foundation NET Program on Regenerative Medicine / Neurosciences (Weaver, UWO) Regenerative Medicine and Nanomedicine Fonds de la recherche en santé du Québec Joint Funding for 6 Strategic Training Initiative Grants McGill University and UQAM Canadian Medical Association Physician Mental Health and Well-Being Grants Brewster (U of Toronto) Development of a guide for common indicators fo Canadian Physician Health Programs Maranda (U Laval) The psychodynamics of the work of physicians: A well-being and mental health issues National Partnerships:  National Partnerships Neurobiology of Psychiatric Disorders and Addictions Grants Programs (to be repeated in 2005) Canadian Psychiatric Research Foundation and Astra Zeneca (with CIHR/Rx&D) Boksa (McGill University) Maternal infection during pregnancy as a risk factor for schizophrenia Li (University of Saskatchewan) A neuroprotective mechanism of atypical antipsychotics in haloperidol-induced neurotoxicity Phillips (University of British Columbia) Biochemical and behavioural characterization of an animal model of schizophrenia induced by sensitization to amphetamine Van Tol (University of Toronto) Identification of psychosis susceptibility genes using C. elegans National Partnerships:  National Partnerships Astra Zeneca Canada / Royal University Hospital Foundation --U. of Saskatchewan / Schizophrenia Society of Saskatchewan Chair on Schizophrenia Ontario Problem Gambling Research Centre Eric Single Studentship Analysis of Canadian Community Health Survey on Mental Health and Well-Being Workshop on Problem Gambling RFA on Research in Addiction Canadian Centre for Substance Abuse (CCSA) Alcohol and Illicit Drugs Forum Joint RFA on Research in Addictions Eric Single Studentship NSERC, NRC, CSA Regenerative Medicine and Nanomedicine National Partnerships:  National Partnerships Health Canada Nicotine Addiction and Tobacco Abuse Regenerative Medicine and Nanomedicine Workshops Suicide Research in Canada Alcohol and Illicits Drugs Statistics Canada Analysis of the Canadian Community Health Survey on Mental Health and Well-Being National Partnerships:  National Partnerships Schizophrenia Society of Canada Co-sponsor of New Investigator Award NeuroScience Canada Barbara Turnbull Award for Spinal Cord Research National Brain Repair Program F. Miller (U of Toronto) Novel Appproach to CNS white matter repais M. Salter (U of Toronto) Transforming research on chronic pain in Canada Y.T. Wang (UBC) Novel therapeutic strategies to repair brain abnormalities in psychiatric disorders National Partnerships:  National Partnerships Vascular Health and Dementia Research Grant Program (to be repeated in 2005) IA, CIHR-Rx&D, Heart and Stroke Foundation of Canada, Alzheimer Society of Canada and Pfizer Canada G. Boulay (Université de Sherbrooke) Intracellular calcium signaling and vascular dementia P. Carlen (University of Toronto) Alzheimer's Disease, Aging and the Ischemic Synapse D. Corbett (Memorial University of Newfoundland) Exercise, aging and cognitive impairment W. Zhang (National Research Council of Canada) Neurovascular Unit in Alzheimer's Disease and Cerebral Amyloid Angiopathy National Partnerships:  National Partnerships Heart and Stroke Foundation of Canada RFA on Nicotine Addiction and Tobacco Abuse RFA on Regenerative Medicine and Nanomedicine Stem Cell and Stroke Networks of Excellence Miller (U of Toronto) Weiss (U of Calgary) International Partnerships:  International Partnerships Japan-Canada Post-doctoral Fellow Exchange Program 3 Japanese post-docs Program terminated and replaced by: JSPS-CIHR Joint Health Research Program New joint funding program with Japan Society for the Promotion of Science INMHA lead CIHR Institute First joint competition – September 2003 One joint grant funded Michael Salter, U. of Toronto Re-issued in September 2004 6 grants funded International Collaborations:  International Collaborations NIH Institutes and NIH Fogarty International Center (see NIH Web Site at www.fic.nih.gov) to be repeated in 2005 Stigma and Global Health joint RFA in 2002 C. Benoit (University of Victoria) Joint RFA to be re-issued in 2005 Tobacco Brain Disorders in the Developing World joint RFA in 2002 to be repeated in 2005 Workshop on Manual Therapies in Bethesda, Maryland, on June 9-10, 2005 with IMHA RFA, Identifiying Autism Susceptibility Genes, and Fragile X Susceptibility Genes International Collaborations:  International Collaborations NIH Institutes and NIH Fogarty International Center RFA on Identifying Autism Susceptibility Genes with many partners including: NIH: NIMH, NINDS, NICHDS, NIEHS, NIDCD CIHR : INMHA, IHDCYH and IG National Alliance for Autism Research Health Research Board of Ireland Southwest Autism Research and Resource Center Cure Autism Now Similar on Fragile X Discussion Nanomedicine International Collaborations:  International Collaborations INMHA-IBRO Neurosciences Schools Partnership with International Brain Research Organization to particularly support neuroscience schools in developing countries African Advanced Neuroscience School September 2003 Two Schools in 2004 Morocco and Argentina Two Schools in 2005 Kenya and Argentina For more details: www.ibro.org International Collaborations:  International Collaborations National Alliance for Autism Research (U.S.) Co-sponsor of two CIHR Strategic Training Programs in Autism Research Eric Fombonne, McGill University Jeannette Holden, Queen’s University Partner in a RFA on Identifying Autism Susceptibility Genes with NIH, CIHR and many partners International Collaborations:  International Collaborations Canada-Finland-China Collaborative Program in Neuroscience Joint Program with the Academy of Finland MOU signed in Finland, Mar. 2005 Many grant applications received International Collaborations:  International Collaborations National Alliance for Schizophrenia and Depression (NARSAD) (U.S.) Joint Young Investigator Awards 2004 Viau (UBC) Misener (University of Toronto) Dozois (UWO) Savard (Laval) Debruille (McGill) Repeated in 2005 Meeting with NARSAD, Schizophrenia Society of Canada and Canadian Psychiatric Research Foundation (Toronto, Sept. 2005) International Collaborations:  International Collaborations WHO / PAHO Mental Health and Addictions in the Developing World WHO Centre in Gender and Mental Health (with IGH) International Collaborations:  International Collaborations Mexico Memorandum of Understanding Signature in Ottawa on October 25, 2002 Institute of Neurology and Institute of Psychiatry China Discussions under way with National Science Foundation INMHA Strategic Priority Three :  INMHA Strategic Priority Three Knowledge Translation Knowledge Translation:  Knowledge Translation Cunningham Modeling parent preferences for translating (McMaster U) scientific knowledge regarding children with inter- nalizing and externalizing mental health problems Forchuk (UWO) Integrating an evidence-based intervention in clinical practice Manske Understanding and testing KT strategies in (U of Waterloo) tobacco control evaluation at national, provincial and local levels McVey Evaluation of a Web-based program designed to (U of Toronto) evaluate the dissemination of best practice models in the primary prevention of disorder eating Varnhagen Strategies for critically appraising children’s health (U of Alberta) web resources Knowledge Translation:  Knowledge Translation In partnership with IHSPR Kisely (Dalhousie U) Measuring quality in mental health services across Nova Scotia evaluation of a demonstration site Dewa (U Toronto-CAMH) Examining the effectiveness of a collaborative care model for individuals with severe mental illness Other KT Initiatives:  Other KT Initiatives Neuroscience Schools in developing countries sponsored in collaboration with IBRO (2 Schools per year) September 1-7, 2004 Cape Town, South Africa September 13-30, 2004 Cordoba, Argentina “Topics in Cellular and Molecular Neuroscience” March 19-27, 2005      Rabat, Morocco "Hormones and Brain“ Nov. 19  - Dec. 6, 2005    Buenos Aires, Argentina “Receptors, Channels, and Synapses” Other KT Initiatives:  Other KT Initiatives Outreach Initiative 2004 Program aimed to help NGO with communication and dissemination of information to target audience First edition in collaboration with IGH Autism Society of Canada Partners seeking solutions with seniors and Creative Retirement Manitoba Canadian Alliance on Mental Illness and Mental Health Canadian Mental Health Association, Ontario Other KT Initiative:  Other KT Initiative Outreach Initiative 2005 Autism Society of Ontario Canadian Coalition for Senior’s Mental Health Center of Neurosciences Studies (Queen’s University) Brain Awareness Week INMHA sponsors BAW in Montreal, Saskatoon,Toronto, British Columbia, and Halifax Other KT Initiatives:  Other KT Initiatives Web site The Brain from top to bottom Link available on INMHA web page www.cihr-irsc.gc.ca/e/8602.html Web site designed to popularize scientific information about the brain and human behaviors and aimed at all public Organized by topics and levels of explanation Approximately 700 visitors/day INMHA Strategic Priority Five :  INMHA Strategic Priority Five Effective Organizational and Operational Structure INMHA Organizational and Operational Structure:  INMHA Organizational and Operational Structure Frequent IAB meeting with summaries on the Web IAB organized in Focus Groups Annual Meeting with all stakeholders Quaterly Newsletter Two staff dedicated to National and International Partnerships Direct involvement in many CIHR committees and working groups Recent and Upcoming Events:  Recent and Upcoming Events Comorbidity and co-occurrence consultation workshop – Sept 22-23, 2005 First Performance Evaluation Report (Fall 2005) Fourth Annual Meeting, Vancouver, October 2005 INMHA-STIHR Workshop in Montreal, Nov. 2005, with NAAR and FRSQ Second Strategic Plan to be developed in 2005-2006 in collaboration with partners How to get in touch with us?:  How to get in touch with us? Montreal Office Rémi Quirion, Scientific Director remi.quirion@douglas.mcgill.ca Richard Brière, Assistant Director richard.briere@douglas.mcgill.ca Ramia Jabr, Executive Manager ramia.jabr@douglas.mcgill.ca Rocio Benalcazar, Administratrive Assistant rocio.benalcazar@douglas.mcgill.ca Astrid Eberhart, Assistant Director, Partnerships / International aeberhart@cihr-irsc.gc.ca Barbara Beckett, Assistant Director bbeckett@cihr-irsc.gc.ca Asimina Xidous, Project Officer axidous@cihr-irsc.gc.ca Eric Marcotte, Lead Lead Regenerative Medicine eric.marcotte@regenerativemedicine.ca Visit us at...:  Visit us at... www.cihr-irsc.gc.ca and read the Brain Brief, INMHA newsletter www.thebrain.mcgill.ca and read about the brain from top to bottom

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