Infectious Disease Git

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Published on May 9, 2009

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INFECTIOUS DISEASE CHAPTER SIX GASTROINTESTINAL AND INTRAABDOMINAL INFECTIONS Acute gastroenteritis (mainly, infectious diarrheas) is second only to cardiovascular disease as a cause of death worldwide. In the U.S., acute gastroenteritis is second only to viral respiratory disease as a cause of acute illness, prompting an estimated 73 million physician consultations each year.

Most episodes are self- limited but infectious diarrhea and various foodborne illnesses account annually for more than 5,000 deaths. Other intraabdominal infections are relatively common and present dilemmas in diagnosis and management. HELICOBACTER Figure 1 PYLORI Helicobacter H. pylori (figure 1) is a pylori - Gram- spiral-shaped, negative, spiral to microaerophilic gram- pleomorphic, negative rod that attaches spiral rod to epithelial cells in the prokaryote. © stomach, especially in the Dennis Kunkel

Microscopy, Inc. antrum, where it resides Used with in the mucous layer. H. permission pylori damages mucous- secreting cells and also promotes an acute and chronic inflammatory response that may lead to a sequence of events: acute gastritis followed by chronic superficial gastritis, then atrophic gastritis, intestinal metaplasia, dysplasia, and adenocarcinoma. The stomach infected with H. pylori also develops lymphoid follicles (lymphoid tissue is not normally present in the stomach), which can evolve into a low-grade

malignancy known as MALT lymphoma. Why some persons develop these various manifestations of H. pylori infections while others do not remains largely unclear. H. pylori colonizes at least one-half of the world’s population, with high colonization rates in developing countries where the infection is usually acquired during childhood. About 35% of persons in the U.S. are colonized and, as the frequency of colonization is about 0.5% per year, about 50% of persons >

60 years of age in the U.S. and other developed countries may be infected. Fecal-oral transmission occurs, and lower prevalence rates correlate with higher standards of living and sanitation. H. pylori is associated with about 70% to 90% of duodenal ulcers, about 70% of gastric ulcers, and with about 60% to 80% of gastric carcinomas. There is evidence that the prevalence of H. pylori in the U.S. has been declining, and it is suggested that this may explain, at least in part,

the declining incidence of peptic ulcer disease and adenocarcinoma of the stomach. However, the incidence of reflux esophagitis, Barrett’s esophagus, and adenocarcinoma of the esophagus in the U.S. has been increasing, leading to the provocative suggestion that certain strains of H. pylori may be protective against the serious consequences of gastroesophageal reflux disease (GERD). FOOD POISONING Figure 2 Centralized food

E. coli (0157:H7) processing and hemorrhagic type. distribution combined Gram-negative, with the growing trend enteric, facultatively toward meals away from anaerobic, rod home make food prokaryote. poisoning an increasingly Potentially fatal to important problem in the humans, contracted U.S. and elsewhere. when contaminated About 5000 outbreaks of meat is cooked food-borne disease are inadequately. © reported to the CDC each Dennis Kunkel year, but the magnitude of Microscopy, Inc. the problem is thought to Used with be far greater. By various permission estimates, 6 million to 81 million cases of food poisoning occur in the Figure 3. U.S. each year, causing Shigella 323,000 hospitalizations dysenteriae - and 5,000 deaths with Gram-negative, expenditures exceeding

enteric, facultatively $5 billion. Symptoms anaerobic, rod range from mild facial prokaryote; causes flushing (Chinese bacterial dysentery. restaurant syndrome) or This species is gastroenteritis to life- most often found in threatening paralysis or water contaminated colitis. Emerging with human feces. problems include the © Dennis Kunkel hemolytic-uremic Microscopy, Inc. syndrome caused by Used with Shiga toxin-producing permission strains of E. coli (notably E. coli 0157:H7 (figure 2) but also others) and Figure 4 increasing drug resistance Vibrio among Salmonella, parahaemolyticus Shigella (figure 3), and - halophilic, other relatively common facultative bacteria. Here we will anerobic, rod review briefly the major bacterium that syndromes of food

poisoning. causes a food- borne illness Bacterial food known as seafood poisoning can result from poisoning. one of 4 mechanisms: Usually Ingestion of food transmitted containing pre-formed through eating toxin is characteristic raw or of food poisoning due undercooked to S. aureus, Bacillus seafood such as cereus (short oysters. Less incubation type), and commonly, this Clostridium botulinum organism can (other than infant cause an infection botulism). Symptoms in the skin when of S. aureus and short- an open wound is incubation B. cereus exposed to warm food poisoning seawater. © Dennis Kunkel typically begin within 1 to 6 hours since the Microscopy, Inc. Used with organism need not

permission multiply in the host in order to cause disease. Symptoms of botulism Figure 5 are delayed because Vibrio the toxin must be parahaemolyticus absorbed and then - halophilic, fixed to neural tissue. facultative Toxin production anerobic, rod within the patient's bacterium that gastrointestinal tract causes a food- following ingestion of borne illness the organism is known as seafood characteristic of food poisoning. poisoning due to Usually Bacillus cereus (long transmitted incubation type), through eating infant botulism, raw or Clostridium undercooked perfringens, seafood such as enterotoxigenic E. oysters. Less coli, Shiga toxin-

commonly, this producing E. coli, and organism can Vibrio cholerae cause an infection infection (01, 0139, in the skin when and non-01). an open wound is Symptoms typically exposed to warm begin 8 hours or more seawater. after ingestion. © Dennis Kunkel Tissue invasion by the microorganism is Microscopy, Inc. Used with characteristic of food- permission borne disease due to Salmonella species, Shigella species, Figure 6 Campylobacter jejuni, Yersinia and invasive E. coli. enterocolitica - Symptoms typically Gram-negative, begin 16 hours or facultatively more after ingestion, anaerobic, rod since the organism prokaryote must multiply and (dividing). This then invade tissue.

bacterium Toxin production and/or releases a toxin tissue invasion is that causes characteristic of infection enteritis with pain due to Vibrio resembling parahaemolyticus (figure appendicitis. © 4 and 5) and Yersinia Dennis Kunkel enterocolitica (figure 6), Microscopy, Inc. which thus seem to cause Used with disease by more than one permission mechanism. Some microorganisms, for example Bacillus cereus, cause disease by more than one mechanism. Salmonella species are the most frequently reported cause of food- borne outbreaks and are sometimes associated

with severe disease. Shigella species, the classic agents of bacillary dysentery, currently cause < 2% of outbreaks in the U.S., while Campylobacter jejuni, although responsible for > 200,000 cases of diarrhea each year, causes <1% of reported food- borne outbreaks. Shiga toxin-producing E. coli strains assume importance disproportionate to their frequency because of the severe complications (discussed below). Listeria monocytogenes causes occasional

outbreaks of food-borne illness in the United States, which can result in life threatening disease especially in young children and among the elderly. Brucella species cause occasional outbreaks of disease (brucellosis) in the U.S. and are usually acquired from cheese made from unpasteurized milk, raw milk, or raw meat. Parasites associated with outbreaks of food-borne disease in the U.S. in recent years include Cyclospora cayetanensis (cyclosporiasis) and Cryptosporidium parvum

(cryptosporidiosis). Listeria monocytogenes has been associated with outbreaks traced to dairy products. The syndromes of food poisoning vary according to the organism, the organ(s) affected and the time of onset after ingestion: Onset within 1 hour suggests ingestion of a chemical. Onset between 1 and 6 hours suggests ingestion of a preformed toxin, usually due to food contaminated with S. aureus or Bacillus

cereus. Onset within 8 to 16 hours raises a number of possibilities, especially bacteria such as Clostridium perfringens and enterotoxin- producing strains of Bacillus cereus that must multiply in the gastrointestinal tract prior to causing disease. Onset beyond 16 hours also raises a number of possibilities, including various bacteria and viruses. Staphylococcal food poisoning and short- incubation B. cereus food poisoning are

characterized by vomiting and crampy abdominal pain. Diarrhea occurs in about one-third of cases. A later onset of crampy abdominal pain with diarrhea is characteristic of Clostridium perfringens and long- incubation B. cereus food poisoning, but these same symptoms can be caused by many other enteric pathogens. INFECTIOUS DIARRHEA: OVERVIEW Infectious diarrhea is the second most common

cause of death worldwide and the leading cause of death in early childhood. In the U.S., infectious diarrhea causes death mainly in older and debilitated persons. However, disastrous consequences can occur in previously healthy persons. Pathogen- associated complications from infectious diarrhea include mycotic aneurysm of the aorta with Salmonella species, the hemolytic-uremic syndrome and renal failure with Shiga toxin- producing strains of E. coli, and Guillain-Barré

syndrome with Campylobacter jejuni. The clinician’s primary task is to discern which patients need further investigation including stool cultures, which need empiric antimicrobial therapy, and which need only quot;tincture of timequot;. According to various estimates, there are > 200 million episodes of diarrhea in the U.S. each year (by one estimate, 1.4 episodes per person), resulting in > 73 million physician consultations, 28 million office visits, 1.8 million hospitalizations, and

5,000 deaths. Answers to a series of questions usually determine the optimum approach to diagnosis and therapy. When a patient presents with diarrhea as the chief complaint, important questions include the following: Is the problem best classified as diarrhea? Diarrhea is usually defined as 3 or more loose stools per day, 2 loose stools with abdominal symptoms, or > 250 grams of stool per day for 7 days. “Loose stools” not meeting one

of these criteria may be part of another illness, or may fall within the range of normal bowel functioning. However, it is acceptable to consider any increased frequency or decreased consistency of bowel movements as “diarrhea.” Is the problem likely infectious or non- infectious? Most cases of community-acquired diarrhea are probably caused by infection. Non-infectious causes include drugs, primary gastrointestinal diseases

such as inflammatory bowel disease, food allergies, endocrine disorders (such as thyrotoxicosis), carcinoid syndrome, and paraneoplastic syndromes. Ischemic colitis due to cocaine should be considered in the differential diagnosis of abdominal pain and bloody diarrhea in a young or middle-aged adult. What is the duration of the illness, and did it begin suddenly or gradually? Sudden onset of diarrhea can be caused

by a pre-formed toxin or by a specific enteric pathogen usually associated with an acute diarrheal syndrome. Diarrhea of gradual onset is often caused by pathogens that tend to cause prolonged diarrheal illness such as Giardia lamblia. What is the epidemiologic setting? Has the patient recently traveled to a developing country? Has the patient recently taken antibiotics (raising the possibility of C. difficile colitis)? Has there been exposure to persons with diarrhea, or

who are at high risk of diarrhea (such as children in day-care centers)? Is there a history of ingestion of unsafe foods (such as unpasteurized milk or cheese, raw shellfish, raw eggs, or raw meat) or water (such as from lakes or streams)? Has there been contact with animals or pets, including reptiles (which are notoriously associated with Salmonella species)? How is the patient’s general health and immunocompetence? Dehydration secondary

to acute diarrheal illness carries increased risk of morbidity and mortality at the extremes of life: infants and the elderly. Persons who are on immunosuppressive medication or who have advanced HIV disease are at high risk of diarrhea due to opportunistic pathogens including parasites. Is the diarrhea likely to involve mainly the small bowel or the large bowel? About 90% of cases of acute, community- acquired infectious diarrhea in the U.S.

represent “small bowel diarrhea” characterized by infrequent watery stools. About 5% to 10% of cases represent “large bowel diarrhea” or the dysentery syndrome, characterized by frequent, small-volume stools that often contain mucus or blood. Frequently, however, the pattern of diarrhea doesn’t fit neatly into one or the other of these categories. Is the diarrhea medically important? Diarrhea is a common experience and usually runs a benign course,

even in persons with underlying conditions. Most patients do not require stool cultures and other studies. The character and duration of the diarrhea, the associated symptoms and signs, and the epidemiologic features usually determine whether further investigation is warranted. SHIGA TOXIN- PRODUCING E. COLI (E. COLI 0157:H7 AND OTHER SEROTYPES) Strains of E. coli that

produce Shiga toxin, also known as enterohemorrhagic E. coli strains, were recognized in the U.S. in 1982 and now cause an estimated 20,000 cases of diarrheal disease each year. Although uncommon in primary care (<1% of all cases of infectious diarrhea), these strains can cause severe hemorrhagic colitis, the hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. E. coli 0157:H7 differs from most E. coli strains

by its production of one or more Shiga toxins and by its inability to ferment sorbitol. Other serotypes of E. coli sometimes produce Shiga toxins, but these are uncommon in the U.S. These E. coli strains adhere tightly to mucosal cells, especially in the ascending and transverse colon. The toxin molecule damages mucosal cells and also enters the systemic circulation, where it causes vascular and endothelial damage that can lead to capillary leak syndrome, thrombosis, hemolysis, and renal

failure. Most human infections have been transmitted by beef, and are thought to result from fecal contamination of meat during slaughter. Undercooked hamburger meat has been famously associated with E. coli 0157:H7 outbreaks. It has been estimated that a hamburger purchased at a fast food restaurant in the U.S. contains meat from as many as 1000 cows. Outbreaks have also been associated with the ingestion of unchlorinated drinking water, unpasteurized apple cider,

alfalfa sprouts, leaf lettuce, mesclun lettuce, radish sprouts, milk, and other foods and beverages. New standards for food processing have been introduced in the U.S. with the aim of reducing the prevalence of this pathogen. However, the infectious dose is low, possibly as low as 100 bacteria. Therefore, prevention is difficult and person-to- person spread may occur. After an incubation period of 3 to 4 days (range 1 to 8 days), patients classically present with crampy

abdominal pain and bloody stools. The pain is often severe and out of proportion to the findings on physical examination of the abdomen. About one third of patients have fever, which characteristically follows the appearance of blood in the stool. Some persons infected with E. coli 0157:H7 remain asymptomatic, and others experience crampy abdominal pain with little or no diarrhea. Most patients, however, have bloody diarrhea caused by hemorrhagic colitis. Data from large series suggest

that up to 90% of patients experience bloody diarrhea at some point during the illness, with about 60% of patients having blood in their stools at the time of presentation. Severe abdominal pain prior to the onset of fever often suggests acute appendicitis, while pain combined with bloody stools suggests inflammatory colitis. SALMONELLA SPECIES OTHER Figure . THAN S. TYPHI Salmonella - rod (SALMONELLOSIS) prokaryote

(dividing); note the Gastroenteritis caused by flagella. Causes non-typhoidal Salmonella salmonellosis (foodstrains is extremely poisoning). (x common in the U.S., with 20,800) © Dennis an estimated 0.8 to 3.7 Kunkel million cases each year. Microscopy, Inc. Many cases, and probably Used with the vast majority of permission sporadic cases, go unrecognized. Outbreaks are usually associated Figure . Isolation Rate for with food products. Between 1985 and 1994, Salmonella Salmonella enteritidis enteritidis by was identified with 582 region, United States, 1974-1994 outbreaks that accounted for 28,058 cases of CDC disease, 2,290 hospitalizations, and 70 deaths. Salmonellae are aerobic

gram-negative rods. Recent studies showing high levels of DNA similarity among Salmonella isolates have led to the reclassification of all clinically important Salmonellae into a single species, Salmonella choleraesuis. There are 7 subgroups of Salmonella choleraesuis, and more than 2300 serovars are recognized based on 3 major antigens (the somatic O antigen, the surface Vi antigen, and the flagellar H antigens). Most clinical laboratories continue to report isolates by their familiar names;

for example, Salmonella typhimurium rather than Salmonella choleraesuis serotype typhimurium. Although S. typhi and S. paratyphi colonize only humans, non-typhoidal Salmonella strains are widespread throughout the animal kingdom. Human disease is usually associated with food products, most commonly poultry and eggs. Infection of poultry flocks is widespread. Ingestion of uncooked or lightly cooked eggs is therefore a risk factor for disease. However, outbreaks and cases have been linked to

numerous foods including tomatoes, alfalfa sprouts, cantaloupe, and freshly squeezed orange juice. Some patients with salmonellosis give a history of keeping exotic pets, especially reptiles, of which up to 90% harbor Salmonella organisms. Salmonella infection is frequently asymptomatic. There is no reliable serologic test, and a single negative stool culture does not exclude the possibility that a food handler might be an intermittent shedder of Salmonella organisms.

Given both the wide distribution of Salmonella in foodstuffs and the frequency of asymptomatic Salmonella carriage, it is difficult to envision how any restaurant might prevent the occasional case of Salmonella transmission despite emphasis on hygienic practices. Salmonella infection is a risk of everyday life, especially for persons who dine out frequently. Salmonella infection nearly always arises by ingestion of the bacteria. Gastric acidity is the first line of host defense, since

Salmonella survives poorly if at all at the normal gastric pH (< 1.5). On the basis of previous data, it has been accepted that ingestion of >105 Salmonella organisms is necessary to cause disease. However, more recent data indicate that a lower inoculum (<103 organisms) can cause disease. Because Salmonella survives well at pH values of 4.0 or higher, persons with atrophic gastritis (which is common among the elderly) or who are taking gastric pH-raising medications (antacids,

H2-blockers, or proton pump inhibitors) are at increased risk of salmonellosis. Containment of Salmonella infection depends on an intact T- lymphocyte system including macrophage function. Persons at risk of serious consequences of Salmonella infection include (1) persons with impaired T-cell function because of lymphoproliferative disorders, other malignancies, HIV disease, or immunosuppressive medication; and (2)

persons with disorders that cause “macrophage blockade” such as hemoglobinopathies (notably, sickle cell disease), bartonellosis, malaria, schistosomiasis, and disseminated histoplasmosis. The 5 recognized syndromes of salmonellosis are gastroenteritis, enteric fever (discussed separately, below), bacteremia and endovascular infection, localized metastatic infections, and the asymptomatic carrier

state. Gastroenteritis due to non-typhoidal Salmonella usually presents as nausea, vomiting, and diarrhea 6 to 48 hours after the ingestion of contaminated food or water. A high inoculum of Salmonella correlates with increased severity and duration of the illness. The stools are usually loose, of moderate volume, and without blood. Occasionally the disease can present as classic “small bowel diarrhea” with large volume, watery stools or as classic “large

bowel diarrhea” with small volume stools accompanied by tenesmus. Fever, chills, nausea, vomiting, and abdominal cramps are common. Occasionally, right lower quadrant pain suggesting acute appendicitis dominates the clinical picture (pseudoappendicitis). Bacteremia is documented, when sought, in up to 4% of immunocompetent persons with Salmonella gastroenteritis. Unrecognized episodes of transient bacteremia are probably common. More

prolonged bacteremia correlates with immunosuppression. Multiple positive blood cultures for Salmonella should raise the possibility of intravascular infection including mycotic aneurysm or endocarditis. Localized metastatic infection occurs in up to 5% to 10% of patients. The major syndromes are as follows: Endocarditis occurs in up to 0.4% (or 1 in 250) patients with Salmonella bacteremia, usually in persons with pre-existing

heart disease. Central nervous system infections including meningitis, ventriculitis, and brain abscess are more common in infants, especially neonates. Osteomyelitis and septic arthritis are encountered most frequently in persons with sickle cell disease, bone disease, or immunosuppression. Osteomyelitis due to Salmonella species most commonly affects the femur, tibia, humerus, or lumbar vertebrae. Septic arthritis due to Salmonella species most commonly affects the

knee, hip, or shoulder. Reactive arthritis affecting multiple joints occurs most often in persons who have the HLA-B27 histocompatibility antigen. Soft tissue infections usually occur in the setting or local trauma and immunosuppression. Urinary tract infection usually occurs in the setting of ureteral or bladder stones, malignancy, renal transplants, or, in some parts of the world, schistosomiasis.

Successful treatment often requires attention to structural abnormalities. Other complications include pneumonia, hepatobiliary infection, splenic infection, and genital infections. The asymptomatic carrier state develops in 0.2% to 0.6% of persons with non-typhoidal salmonellosis, and is more common in women and in persons with abnormalities of the biliary tract. The long-term carrier state is defined by persistence of Salmonella in stool

or urine cultures for > 1 year. SHIGELLA SPECIES (SHIGELLOSIS) Shigella species are the classic agents of dysentery and are highly communicable. Shigellosis remains an important cause of morbidity and mortality in developing countries, mainly in children. At least 19,000 cases occur in the U.S. each year. Shigella are gram- negative bacilli with 4 recognized serogroups:

group A (Shigella dysenteriae), group B (Shigella flexneri), group C (Shigella boydii), group D (Shigella sonnei). Within these 4 serogroups are about 40 serotypes, of which Shigella dysenteriae serotype 1 (also known as the Shiga bacillus) causes the most severe disease. Shigella sonnei now accounts for about 60% to 80% of cases of shigellosis in the U.S. Like Salmonella, Shigella can contaminate food and water, causing occasional common source outbreaks. However,

person-to-person transmission is the dominant mode of transmission. As few as 10 to 100 Shigella organisms can cause disease; therefore, shigellosis is highly communicable. After exposure to a case of shigellosis in a household, about 40% of persons between and 1 to 4 years of age and about 20% of persons of all ages develop the disease. Outbreaks of shigellosis occur in crowded, closed environments such as nurseries, day care centers, institutions, and

cruise ships. Following ingestion, Shigella organisms multiply in the small intestine resulting in concentrations of 107 to 109 bacteria per mL of intestinal fluid. Symptoms commonly result from small intestinal involvement, but the hallmark symptoms of shigellosis—the dysentery syndrome— result from mucosal invasion and toxin production in the colon. Inflammation is severe but relatively superficial, and bacteremia is

therefore uncommon. CAMPYLOBACTER SPECIES Figure Campylobacter Diarrhea caused by jejuni is an Campylobacter jejuni is enteric, curved- one of the most common rod prokaryote infectious diseases (bacterium). It is worldwide. More than 1 the bacterium that million cases occur each causes year in the U.S., where campylobacterios Campylobacter is isolated is, one of the from stool cultures more most common frequently than either bacterial causes Salmonella or Shigella of diarrheal species. Campylobacter illness in the jejuni is therefore an United States. It important pathogen in is a relatively primary care. fragile bacterium Campylobacter fetus is

that is easily encountered much less killed by cold or frequently and presents as a bacteremic illness. hot temperatures. Birds are carriers Campylobacter species due to their body are small, comma-shaped temperature or curved gram-negative being just right to bacilli, of which C. jejuni host the bacteria. and C. fetus are of Improper medical importance. C. handling of raw jejuni causes an intestinal poultry or infection manifested as undercooked acute gastroenteritis and fowl is usually colitis. Campylobacter the source of fetus is more likely to infection in cause a systemic infection humans. © with bacteremia, Dennis Kunkel meningitis, intravascular Microscopy, Inc. infections including Used with endocarditis, and permission metastatic abscesses. Human disease is

predominantly food-borne but can result from direct contact with animals, including household pets (notably, puppies or kittens with diarrhea). Fecal-oral transmission occurs, and men who have sex with men are at increased risk. However, transmission from food handlers appears to be uncommon. Some studies suggest that disease can result from ingestion of as few as 500 bacilli. Like Salmonella, Campylobacter is inhibited by hydrochloric acid in the stomach and might therefore occur

more commonly when gastric pH is raised because of gastritis or medications. Campylobacter species invade the intestinal mucosa and also elaborate various extracellular toxins with cytopathic activities. Campylobacter jejuni causes disease throughout the year in the U.S., but sharp peaks of Campylobacter disease occur during the summer and early fall. The disease especially affects children < 1 year of age and persons between 15 and 29 years of age. This

pattern in the U.S. contrasts sharply with the pattern in developing countries, where Campylobacter affects persons of all ages and especially during the first 5 years of life. Mishandling of raw poultry and consumption of undercooked poultry are now considered to be the major risk factors to Campylobacter infection. The incubation period of Campylobacter jejuni gastroenteritis is usually between 1 and 7 days (average, 2 to 4 days). In about two thirds of cases, the disease begins with

abdominal pain and/or diarrhea. The remaining patients have a prodrome that suggests a flu-like illness (see below). Pain is often severe and can be the predominant symptom. In other patients, fever is the predominant manifestation of the disease. The diarrhea can consist of frequent loose stools, massive watery stools, or grossly bloody stools. Most patients (at least 50% in one study) have 10 or more bowel movements on the worst day of the illness. Gross blood is commonly

present in bowel movement during the second and third days of the illness. Mild leukocytosis is often present. CLOSTRIDUM DIFFICILE AND ANTIBIOTIC- ASSOCIATED COLITIS Diarrhea is a relatively common complication of antimicrobial therapy and is associated with Clostridium difficile in about 10% to 30% of cases. Pseudomembranous

colitis due to C. difficile, the most severe form of antibiotic-associated diarrhea, occurs in about 1 in 10,000 courses of antibiotic therapy in ambulatory patients. C. difficile elaborates two large toxin molecules, an enterotoxin known as toxin A and a cytotoxin known as toxin B. About 60% of adults in the U.S. have serum antibodies to C. difficile, suggesting that asymptomatic colonization is relatively common. Prevalence surveys indicate colonization of the colon by C. difficile in about

3% or less of healthy adults, 2% to 8% of elderly persons in nursing homes, and up to 20% of persons who are hospitalized. Person-to- person transmission of C. difficile occurs, and can be reduced by handwashing before and after patient encounters and by use of disposable gloves (followed by handwashing) during direct contact with patients. Symptoms typically begin 5 to 10 days after a course of antimicrobial therapy, but can start as early as the first day of treatment

and as late as 10 weeks after treatment has been discontinued. A common presentation consists of acute onset of watery diarrhea with low-grade fever and abdominal pain. The disease ranges in severity from mild to fulminant. Overall, about 30% to 50% of patients have fever and 20% to 33% have abdominal pain. Despite prominent involvement of the rectosigmoid area in most cases, gross blood is seldom present in the stool.

MISCELLANEOUS GASTROINTESTINAL PATHOGENS VIRUSES One of the most common human infections, viral Figure . gastroenteritis causes an Rotavirus (A estimated 3 to 5 billion double-capsid particle (left), and a cases of diarrhea each year, worldwide, with single, inner, capsid (right)) © Dr some 5 to 10 million deaths. Linda Stannard, University of Cape Rotaviruses Town, South Africa Rotaviruses, so-named because they resemble a wheel complete with spokes under the electron microscope (rota is Latin for “wheel”), cause about

one-third of all diarrhea- related hospitalizations worldwide, with about 800,000 deaths each year. Nearly all children are infected by age 3 years. In the U.S., diarrhea due to rotaviruses accounts for an estimated 500,000 physician visits, 50,000 hospitalizations, and 20 to 40 deaths, at an annual cost > $1 billion. Of the 3 recognized groups of rotaviruses (A, B, and C) are recognized, group A accounts for most outbreaks. The disease is presumably spread mainly by fecal- oral transmission, which

explains in part its high frequency in childcare centers. Rotaviruses infect villous epithelial cells in the jejunum and ileum. Children with rotavirus infection typically present with fever, vomiting, and diarrhea. Dehydration can be significant. Adults remain susceptible to rotavirus infection, but serious morbidity and mortality is rare except among the elderly. Outbreaks of rotavirus diarrhea can occur in nursing homes, sometimes with dehydration and death.

NOROVIRUSES AND OTHER CALICIVIRUSES Caliciviruses, so-named because of cup-life indentations on their Figure . surfaces (calix is Latin for Norwalk virus from “cup” or “goblet”) cause stool sample from vomiting, diarrhea, or an individual with both. Noroviruses gastroenteritis. (previously called the F.P. Williams, U.S. Norwalk agent, after an Environmental outbreak in Norwalk, Protection Agency Ohio, led to the first isolation) and similar agents cause more than one-third of outbreaks of nonbacterial gastroenteritis in the U.S.,

affecting persons of all age groups. Some studies suggest that up to 90% of persons are eventually infected. Like rotaviruses, caliciviruses are spread mainly by fecal-oral transmission and infect villous cells in the small intestine, causing diarrhea as a result of malabsorption. Onset of illness can be gradual or abrupt, with crampy abdominal pain being the usual first symptom. Most patients develop both vomiting and diarrhea, but either of these symptoms can predominate. Some

patients experience only mild watery diarrhea, while others have a more severe illness with vomiting, headache, and constitutional symptoms. Caliciviruses have been difficult to isolate by culture. No convenient diagnostic test is available, although numerous tests are in various stages of development. Treatment is supportive, and rapid recovery within 48 to 72 hours is the rule. Astroviruses and other agents of viral

gastroenteritis Astroviruses and enteric (group F) adenoviruses have been firmly established as causes of diarrhea. Astroviruses cause diarrhea primarily in young children. Serologic studies indicate that the majority of children are infected by 6 years of age. Illness is usually manifested by headache, malaise, and diarrhea, with nausea being less common. The illness tends to be milder than rotavirus diarrhea, although occasional patients require hospitalization.

Secondary cases in adult contacts are less common, and experimental studies indicate that astroviruses usually do not produce symptoms in adults. Both astroviruses and enteric adenoviruses have been isolated by culture. A commercially available test is available for detection of enteric adenoviruses, which also cause diarrheal disease in children. Other viruses that may sometimes cause diarrhea but in which the etiologic or causal relationship has not yet been firmly established include

coronaviruses, echoviruses, coxsackie A and B viruses, non-group F adenoviruses, picobirnaviruses, picotrirnaviruses, pestiviruses, and toroviruses. E. COLI OTHER THAN SHIGA TOXIN- PRODUCING STRAINS Escherichia coli, a major component of the normal intestinal flora and the most carefully studied of all living organisms, causes diarrhea by at least 6 mechanisms, identified

by the adjectives used to describe the respective strains: Shiga-toxin producing strains (STEC; also called enterohemorrhagic E. coli or EHEC), discussed above. Enterotoxigenic strains (ETEC), the usual cause of traveler’s diarrhea. Enteroinvasive strains (EIEC), which cause dysentery with high fever and bloody diarrhea that contains polymorphonuclear leukocytes. These strains belong to certain serogroups (such as

028, 052, and 0112), which are rare in the U.S. Enteropathogenic strains (EPEC) cause disease by adhering tightly to epithelial cells and effacing their brush borders. These strains, also called “enteroaggresive,” have been associated with nursery outbreaks and with persistent diarrhea in young children. Enteroaggregative strains (EAEC, also known as EaggED) adhere to cells and seem to cause diarrhea by several mechanisms

including both stimulation of the guanylate cyclase system and also cytotoxicity. These strains have been associated with diarrhea mainly in developing countries, but also cause persistent diarrhea in persons with advanced HIV disease. Diffusely adherent E. coli (DAEC) may cause disease by massive attachment to the gut mucosa, thereby diminishing the absorptive surface. Diagnosis of E. coli as the cause of diarrhea in one

of the latter syndromes is usually not accomplished by most clinical laboratories. Therefore, consultation with a state health department may be advisable when an outbreak of severe diarrhea occurs and cultures for the usual pathogens are unrevealing. CHOLERA AND NON- CHOLERA VIBRIOS Figure . Vibrio cholerae - Vibrio cholerae causes a Gram-negative, life-threatening secretory facultatively diarrhea by stimulating anaerobic, curved the adenylate cyclase (vibrio-shaped), rod system of the

prokaryote; causes gastrointestinal tract. The Asiatic cholera. © disease presents abruptly Dennis Kunkel with watery diarrhea. Microscopy, Inc. Fever and abdominal pain Used with are seldom prominent, if permission they occur at all. Death occurs by dehydration. Treatment requires aggressive fluid replacement, with antibiotics having a secondary role. Cholera is rare in the U.S., being seen almost exclusively in travelers, but the possibility of an eighth pandemic of the disease remains real. Vibrio parahemolyticus is an important cause of gastroenteritis associated

with the ingestion of inadequately cooked seafood or food that has been contaminated with seawater. Raw oysters are incriminated in about one-half of cases in the Gulf Coast states, where the disease is most common in the U.S., but outbreaks are associated with other types of shellfish. Between 1973 and 1998, 40 outbreaks of V. parahemolyticus infection were to the CDC, accounted for > 1000 illness. Explosive watery diarrhea is usually the first symptom and is often accompanied by

crampy abdominal pain. The organism can be isolated on TCBS agar. The disease is usually mild and self-limited, but occasional deaths occur in young children, elderly persons, or persons who are severely debilitated. ENTERIC FEVER (TYPHOID AND Figure Rose spots on the PARATYPHOID chest of a patient FEVERS) with typhoid The elimination of fever due to the typhoid as a major public bacterium health problem in the Salmonella typhi. U.S. was due largely to Symptoms of improved sanitation typhoid fever rather than to antibiotics

may include a or to the vaccine, which is sustained fever as only partially effective. high as 103° to Occasional outbreaks of 104° F (39° to typhoid fever still occur, 40° C), weakness, but about three-fourths of stomach pains, cases are acquired abroad, headache, loss of and especially from appetite. In some Mexico, the Philippines, cases, patients and India. The risk of have a rash of typhoid among U.S. flat, rose-colored travelers is greatest spots. among those who visit the CDC/Armed Indian subcontinent. Forces Institute Paratyphoid fever is an of Pathology, enteric fever syndrome Charles N. due to Salmonella species other than S. typhi. Farmer Typhoid fever is caused by Salmonella choleraesuis subspecies choleraesuis serotype

typhi, commonly known as S. typhi. A similar illness is caused by Salmonella paratyphi A, Salmonella schottmuelleri (formerly S. paratyphi B), and S. hirschfeldii (formerly S. paratyphi C), and occasionally by other Salmonella species. Enteric fever is a “penetrating” intestinal infection in the sense that the bacteria penetrate the small bowel mucosa, where the multiply in intestinal lymphoid tissue and especially in the large aggregates of lymphocytes in the ileum known as Peyer’s

patches. Lymphohematogenous dissemination results in high fever and other disease manifestations. The organisms grow within reticuloendothelial cells, and satisfactory host defenses require intact cell-mediated (T- lymphocyte) immunity. Typhoid fever usually affects persons < 30 years of age (children, adolescents, and young adults). After an incubation period of 5 to 21 days, patients present with abdominal pain, fever, chills, and constitutional symptoms.

Diarrhea is seldom the presenting complaint, and about 30% of patients, especially adults, experience constipation rather than diarrhea. The illness characteristically evolves over several weeks: First week: stepwise fever that becomes sustained (that is, the temperature does not return to the baseline), often with relative bradycardia and usually with positive blood cultures. Second week: abdominal pain, often (but < 50% of cases)

with a rash consisting of faint salmon-colored macules on the trunk and abdomen (rose spots). Third week: hepatosplenomegaly with, in severe cases, intestinal bleeding and/or perforation caused by erosions of Peyer’s patches. Complications include shock, stupor, delirium, seizures, psychosis, myelitis, and pneumonia. Diagnosis is most conveniently made by blood cultures, which are positive in 40% to 80% of

patients. BILIARY TRACT INFECTIONS Cholecystitis and cholangitis are relatively common causes of acute, recurrent, and chronic abdominal pain. Occasional complications of biliary tract disease include acute pancreatitis caused by gallstones and liver abscess. Cholecystitis usually results from obstruction of the cystic duct with subsequent bacterial invasion of the

gallbladder. In the U.S., cholelithiasis is the cause of cystic duct obstruction in > 90% of cases, and women are affected twice as frequently as men. Cholecystitis can be acute or chronic. More often than not, both types of inflammation are present, as evidence of chronic inflammation including fibrosis is found in about 95% of gallbladders removed for presumed acute cholecystitis. Acute cholecystitis, with or without gallstones, typically presents with pain in the right upper quadrant of the abdomen,

fever, nausea, and vomiting. Common pathogens in biliary infections include aerobic gram-negative bacilli (e.g., E. coli, Klebsiella species, Enterobacter species, Proteus species, and Pseudomonas aeruginosa), aerobic gram-positive cocci (enterococci, streptococci, and staphylococci), and anaerobic bacteria (e.g., Bacteroides species, Clostridium species, Fusobacterium species, and peptostreptococci). Acute ascending cholangitis (also called toxic or suppurative

cholangitis) occurs in the setting of common bile duct obstruction, most commonly from gallstones (choledocholithiasis). Other causes of common bile duct obstruction include benign or malignant strictures, extrinsic compression, and parasitic infestation (usually Ascaris lumbricodes in the U.S.). Patients with acute ascending cholangitis often have evidence of severe sepsis, and about 50% to 60% of patients manifest “Charcot’s triad” of fever, jaundice,

and right upper quadrant abdominal pain. ACUTE APPENDICITIS AND MESENTERIC LYMPHADENITIS (PSEUDOAPPENDICI TIS SYNDROME) Acute appendicitis should be considered in all patients with fever, right lower quadrant abdominal pain, anorexia, and vomiting. However, these finding are nonspecific and the clinical presentation of acute appendicitis can be atypical. Several diseases closely mimic acute appendicitis

including mesenteric lymphadenitis. Studies suggest that 8% of all persons and up to 20% of admitted to the hospital for suspected acute appendicitis may have mesenteric lymphadenitis instead. Acute appendicitis is usually caused by obstruction of the organ’s narrow lumen by fecaliths, foreign bodies, enlarged lymphatic follicles, or tumors. The mucosa and wall become ischemic, promoting bacterial invasion. Unchecked, the inflammatory process

progresses to gangrene (infarction) and then perforation, allowing aerobic and anaerobic bacteria to enter the peritoneal cavity. Peritonitis can be localized as a right lower quadrant mass or abscess, or can be generalized. In either case, patients usually become septic. Mesenteric lymphadenitis (pseudoappendicitis) is most commonly caused by Yersinia enterocolitica and Yersinia pseudotuberculosis. Non- typhoid Salmonella species and Campylobacter jejuni

have also been associated with this syndrome. Streptococci were not infrequently associated with this syndrome in the preantibiotic era. Unusual etiologies reported in recent years include infectious mononucleosis (Epstein-Barr virus) and intestinal anthrax. ACUTE DIVERTICULITIS Acute diverticulitis is a common problem in primary care because of the high prevalence in our society of diverticulosis of the colon. Acute

diverticulosis is often self-limited, but can lead to serious complications including sepsis, intraabdominal abscess formation, and death. Acute diverticulitis is actually a “peridiverticulitis” in that the inflammatory reaction is almost entirely extrinsic to the colon. Microperforations of diverticula cause contamination of the peritoneal cavity by the aerobic and anaerobic flora resident to the normal colon (notably, Bacteroides species, E. coli, and enterococci). The result is often a small abscess within the pericolonic fat (Stage 1)

that, if not contained, may expand and spread (Stage 2) and then rupture, causing generalized suppurative peritonitis (Stage 3). If the bowel lumen communicates with the inflammatory process, more colonic contents enter the peritoneal cavity leading to extensive fecal contamination of the peritoneal cavity and intraabdominal abscesses (Stage 4). PERITONITIS Intraabdominal infections can be confined to the peritoneal cavity, to one or another organ, or, more

commonly involve both. Infectious peritonitis can be diffuse or localized. Examples of localized peritonitis secondary to acute cholecystitis, acute appendicitis, and acute diverticulitis have already been discussed. Diffuse (generalized) peritonitis and intraabdominal abscess nearly always mandate admission to the hospital. Primary peritonitis (spontaneous bacterial peritonitis) occurs in up to 10% of patients with alcoholic cirrhosis) and occurs rarely in patients with ascites caused by

congestive heart failure, nephritic syndrome, metastatic tumors, systemic lupus erythematosus, or other disorders. E. coli is the most common infecting bacterium. Anaerobic bacteria are rare in primary peritonitis. Peritonitis can also be caused by tuberculosis, Neisseria gonorrhoeae and Chlamydia trachomatis infections. Secondary peritonitis usually results form spillage of bacteria from the gastrointestinal tract, as occurs in acute appendicitis with rupture,

acute diverticulitis, ischemic bowel disease, intestinal obstruction due to neoplasm, and penetrating injuries. Other causes of secondary peritonitis include acute suppurative cholecystitis (see above), chronic ambulatory peritoneal dialysis, complicated genitourinary tract infections, and ruptured abscess from an intraabdominal organ such as the liver, pancreas, kidney, or fallopian tube. Secondary peritonitis typically involves both aerobic and anaerobic bacteria.

Intraabdominal abscesses arise from one of several mechanisms: (1) local spread of infection within the peritoneal cavity; (2) hematogenous seeding of an organ; and (3) necrosis of an organ followed by bacterial colonization and superinfection.

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