HIV Vaccine

33 %
67 %
Information about HIV Vaccine
Health & Medicine

Published on March 11, 2014

Author: mahmoodi2000


60 million people, infected since 1981 39.5 million people are living with HIV 4.3 million new infections in 2006 Over 28 million have died since 1981 Ten new infections occur every minute

Facts Special Features of HIV Human Immune System Response Ideal HIV Vaccine Current Achievements Prospective

FactsFacts  AIDS kills more people than any other infectious disease  Impact on economics  Unreliable pharmacotherapy  HIV is the best studied pathogen  Yet we don’t have any vaccine for it

Facts Special Features of HIV Human Immune System Response Ideal HIV Vaccine Current Achievements Prospective

Special Features of HIV  HIV is highly mutable  Genetically diverse population of viruses  Too variable epitopes of the viral envelope  Masking of gp120  High levels of viral replication Long latent period of infection

Special Features of HIV GP 120

Slide 7.37

Facts Special Features of HIV Human Immune System Response Current Achievements An Ideal HIV Vaccine Prospective

Human Immune System Response Humeral immunity

Human Immune System Response Cell-mediated immunity

Facts Special Features of HIV Human Immune System Response Current Achievements An Ideal HIV Vaccine Prospective

Current Achievements Since 2000 30 vaccine versions have been tried  Many clinical trials are ongoing in developing countries  Large scale AIDS vaccine trials could be conducted

Current Achievements

Live Attenuated Whole Killed Live Vector Re- combinant Proteins DNA Vaccines Pseudo virion Vaccine Types Current Achievements

Whole, Killed HIV  Not under study in primates  No useful immunity  Difficult to maintain viral configuration  Difficult to make large quantities

Live, Attenuated HIV Studied in non- human primates Has pathogenic potentiality

Live Vector Vaccines  Phase I and II trials  Inserting HIV or SIV genes into viruses or bacteria  Effective humoral and cellular immune responses

Recombinant Viral Protein Vaccines  Phase III  Uses viral surface antigens as immunogens  Uses genetically engineered bacteria, yeasts, insects or cell cultures

Naked DNA Vaccines  Stages I , I/II and II  Synthesizing antigens using host-cell’s machinery  Presented on the cell surface with host MHC class I and class II molecules

Pseudovirions Pre-clinical trials Virus-like particles Self-assembling, non- replicating, virus-sized structures

Facts Special Features of HIV Human Immune System Response Current Achievements An Ideal HIV Vaccine Prospective

An Ideal HIV VaccineAn Ideal HIV Vaccine Sterilizing Long-term controlled infection Transient Infection Altruistic vaccine

Epidemiological Aspect Individual Aspect An Ideal HIV VaccineAn Ideal HIV Vaccine

Efficacy  Protection from infection Sterilizing immunity  Protection from disease Reduction in set point viral loads Time after infection Viralload Ideal vaccine Peak Set point Sub optimal vaccine

Facts Special Features of HIV Human Immune System Response Current Stand An Ideal HIV Vaccine Prospective

Total New Infections Averted By An AIDS VaccineNewinfectionsinmillion Vaccine introduction Base Low scenario Medium scenario High scenario Total new infections averted by an AIDS vaccine between 2015-2030 30% efficacy 20% coverage 50% efficacy 30% coverage 70% efficacy 40% coverage 5.5 million 28 million 17 million 28 million

Is an AIDS vaccine really Preparable? Is an AIDS vaccine really Preparable? In 1984 researchers predicted that a vaccine was right around the corner…

INTERNATIONAL HEALTH SECURITY 2007 …..HIV/AIDS threatens the stability of entire regions and nations…. While there are major efforts under way to find a vaccine and to expand access to affordable treatments, much more still needs to be done…

What To Do Now?

Conclusions  The scale of HIV problem is huge  Humanity needs an effective vaccine to end the pandemic  Developing an HIV vaccine is a laborious task  HIV vaccines on different stages of trials are only partially effective  The best primary prevention up till now is : - Health education - Personal protection

Acknowledgments  Dr. Seyed Mohsen Mahmoodi  Dr. Abdel Hamid Elhawary  Mr. Mohammad Reza Rahimi  Dr. Rizwana Sheikh

THANKTHANK YOU!!!YOU!!! You Can Visit My Website:

Add a comment

Related presentations

Related pages

HIV Vaccine Research

HIV Vaccine Research. Historically, vaccines have been our best weapon against the world’s deadliest infectious diseases, including smallpox ...
Read more

HIV Vaccines -

What Are Vaccines and What Do They Do? A vaccine—also called a “shot” or “immunization”—is a substance that teaches your body's immune system ...
Read more

Home - IAVI - International AIDS Vaccine Initiative

The International AIDS Vaccine Initiative (IAVI) is a global not-for-profit organization whose mission is to ensure the development of safe, effective ...
Read more

HIV Vaccine Trials Network

The HIV Vaccine Trials Network is the world’s largest publicly-funded international collaboration focused on the development of vaccines to prevent HIV/AIDS.
Read more

WHO | HIV Vaccines

Contents:: What it is:: Why it is Important:: How it is Done:: Cost Information:: Key References. What it is. Vaccines stimulate the body’s immune system ...
Read more

HIV Vaccines: Trials of Preventive Vaccines and ...

A look at where we are in developing an HIV vaccine. ... Types of HIV Vaccines Being Tested continued... Therapeutic HIV vaccines:
Read more

HIV vaccine - Wikipedia, the free encyclopedia

An HIV vaccine is a vaccine which would either protect individuals who do not have HIV from contracting that virus, or otherwise may have a therapeutic ...
Read more

AIDS Vaccines | AVAC

There is momentum and promise in the search for an AIDS vaccine. An effective preventive AIDS vaccine would teach the body how to prevent HIV infection.
Read more

HIV vaccine trial gets go ahead in Africa at AIDS ...

Durban (CNN)A vaccine against HIV will be trialed in South Africa later this year after meeting the criteria needed to prove it could help fight ...
Read more

HIV Vaccine: How Close Are We? - Healthline

An HIV/AIDS vaccine would theoretically have two goals. It could be administered to healthy individuals to protect them from being infected with the HIV virus.
Read more