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Product-Training-Manuals

Published on June 19, 2007

Author: Mahugani

Source: authorstream.com

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Responsive Drug Delivery System:  Responsive Drug Delivery System Presenter: Bo He 12/10/03 Outline:  Outline Traditional drug dosing andamp; introduction to responsive drug delivery systems Commercially available sensors andamp; drug delivery systems Responsive drug delivery systems under development Challenge andamp; perspective Traditional Drug Dosing:  Traditional Drug Dosing Medicine or injections Each person responds uniquely Noticeable symptoms are not sufficient to support timely and accurate dosing Examples- diabetes, cardiovascular disease, acute pain Controlled release – frequent exposure, side effects, tolerance Responsive Drug Delivery Systems:  Responsive Drug Delivery Systems Combination of Biosensors andamp; controlled release system Revolutionized medicine by enabling individualized therapy Sense continuously to manage unpredictable condition Immediate respond with appropriate countermeasure Give the patients more flexibility and less disruption of the daily life Example: Insulin Pumps:  An insulin reservoir (like a regular syringe) A small battery operated pump A computer chip for control Infusion set- a thin plastic tube to deliver insulin to the body Pump therapy A basal rate andamp; bolus insulin Combination with Glucose sensors Example: Insulin Pumps The Importance of Control:  The Importance of Control Programmed release controlled by microchips More flexibility andamp; less pain Reduced the risk of side effects More than 200,000 people in the US wear insulin pumps Ideal Responsive Drug Delivery:  Ideal Responsive Drug Delivery Disadvantages of available systems Not automatic, the user has to decide the dose The results are not always reliable Sensors and controlled drug delivery systems are not combined Ideal systems Sense minute amounts of marker molecules Immediate response In vivo detection and delivery Small, biocompatible, accurate and reproducible Type of Drug Delivery:  Type of Drug Delivery Biosensors, e.g. Glucowatch:  Biosensors, e.g. Glucowatch Biographer: non-invasive, watch-like device that measures glucose AutoSensor: a plastic part that snaps into the Biographer and sticks to the skin. Noninvasive andamp; automatic reading every 10 mins up to 13h Comparison of Glucose Readings :  Comparison of Glucose Readings How does Glucowatch work?:  How does Glucowatch work? Based on reverse iontophoresis A low electric current pulls glucose through the skin. Glucose is accumulated in two gel collection discs in the AutoSensor. Another electrode in the AutoSensor measures the glucose. Enzymatic pathway:  Enzymatic pathway Controlled-release device:  Controlled-release device Affecting factors Compositions of osmotic agent Thickness of semipermeable membrane Surface area Responsive drug delivery systems:  Responsive drug delivery systems Smart polymer Antigen-antibody interaction Closed loop systems Sensing and delivery combo system Antigen-antibody interaction smart polymers:  Antigen-antibody interaction smart polymers A semi-interpenetrating polyacrylamide (PAAm) hydrogel Antigen—rabbit immunoglobulin G( rabbit IgG) Antibody—goat anti-rabbit IgG (GAR IgG) Takashi Miyata et al., Nature, vol 399 ,766 Antigen-antibody interaction smart polymers:  Antigen-antibody interaction smart polymers Effect of free antigen concentration on the hydrogen swelling ration Antigen recognition by antigen-antibody semi-IPN hydrogel Antigen-antibody interaction smart polymers:  Antigen-antibody interaction smart polymers Reversible swelling changes Antigen-responsive permeation (a model protein drug haemoglobin through a membrane fabricated from hydrogel ) Schematic of Self Regulating Responsive Therapeutic System:  Schematic of Self Regulating Responsive Therapeutic System Challenge:  Challenge Commercially available systems Expensive yet not always reliable Not automatically responsive Not completely in vivo Systems under development Short lifetime and hard to reproduce Slow response time Biocompatibility (coating) References:  References Sapna K. Deo; et al. Analytical Chem. 2003, 206A-213A. www.minimed.com www.glucowatch.com R. T. Kurnik et al. Electrochem. Soc. 1998, 145, 4119-4125 Miyata, T. et al. Nature 1999, 399, 766–769. Zhang, K.; Wu, X. Y. J. Controlled Release 2002, 80, 169–178. Tanihara, M. et al. J. Pharm. Sci. 1999, 88, 510–514. www.chiprx.com www.acs.ohio-state.edu/unit/research/archive/muscles.htm Metzger, M. et al. Diabetes Care 2002, 25, 1185–1191. Thank You:  Thank You

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