Published on February 27, 2014
Mother of all antioxidants The Master Detoxifier and Maestro of the Immune System GLUTATHIONE Why your body needs a regular supply of this critical substance? Protects against oxidative stress Produced naturallyby every cell of your body Reduces cellular inflammation
What is Glutathione? Glutathione is a very simple molecule that is produced naturally all the time in your liver. It is a combination of three simple building blocks of protein or amino acids -cysteine, glycine and glutamine. It contains –SH group that acts like flypaper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals. Poor diet, pollution; toxins, medications, stress, trauma, aging, infections and radiation all deplete your glutathione. This leaves you susceptible to unrestrained cell disintegration from oxidative stress, free radicals, infections and cancer. And your liver gets overloaded and damaged, making it unable to do its job of detoxification. Glutathione production in the body begins to slow down after around 25 years of age. Depleted level of glutathione creates a condition where the body has to decide whether to use it for supporting immune system or for muscular system or for any other function.
PRODUCTION OF GLUTATHIONE IN THE LIVER Glutathione Precursors Supplementation For a cell to be able to manufacture Glutathione these three GSH precursors - glutamine, glycine and cysteine - absolutely must be in a form that can be transported from the mouth, through the digestive system, into the blood and finally through the cell wall where they are combined into Glutathione. Glutamate and glycine are readily available in most Western diets; cysteine, however, is a limiting factor of GSH production. One reason cysteine is a limiting factor for GSH is that cysteine does not survive the trip to the cell through the digestive system very well. Most cysteine is broken down or altered somewhere along the long trip from the mouth to the cell. That is why it is important to consume cysteine in a form that resists alteration and is strong enough not to be broken down in the digestive tract. Supplement containing glutathione precursors is better than glutathione itself if it is to be taken orally.
INGREDIENTS GLYCINE Glycine is produced in the body from the amino acids serine and threonine. Glycine is found to be useful in assisting with the absorption of calcium in the body and the manufacturing of hormones responsible for a strong immune system. Glycine is also an inhibitory neurotransmitter in the central nervous system (especially in the spinal cord, brainstem, and retina of an eye), which makes it important to help prevent epileptic seizures. Glycine helps in slowing down the degeneration of muscles since it helps to supply extra creatine in the body. GLUTAMATE Glutamate is a key molecule in cell metabolism and it acts as a neurotransmitter in the brain. It also acts as a substrate for DNA synthesis. Apart from these two roles, glutamine also serves as a source of fuel for enterocytes, which are cells that line the inside of the small intenstine, acting as the precursor for multiplying immune cells, as well as helps to promote a healthy immune systems. N-ACETYL CYSTEINE It is an easy way to deliver an amino acid -- same as the stuff you eat every day, in protein -- called cysteine, which otherwise does not easily reach brain cells. Cysteine has two potential ways of working. In some research studies, it was used for one reason but may have actually worked through the other! Overall Functions of the Glutathione Precursors Restores and increases muscle mass Decreases body fat Increases energy and stamina Lowers high cholesterol profile Improves vision Promotes mental ability while enhancing memory Elevates mood and improves sleep Normalizes blood pressure Increases cardiac output and stamina Improves immune function Decreases sugar cravings and the desire for alcohol Helps maintain a healthy digestive tract Helps to build and maintain muscle Helps to maintain proper pH (acid/alkaline) balance
Who can benefit? This simple molecule has been studied and shown to be better than a placebo for the treatment of bipolar depression schizophrenia autism compulsive hair-pulling ("trichotillomania") and obsessive compulsive disorder addictive behaviors: cocaine craving; gambling; marijuana use; and cigarette smoking (decrease use but not craving) and preliminary evidence (not studied yet against placebo, or in humans) for the following: compulsive nail-biting reversing the brain changes induced by cocaine (in rats, anyway) Other health claims Some other possible benefits less relevant to mental health: NAC has been claimed or shown to lower the rates of viral infections, treat fluid in the ear, lower heart disease risk by lowering homocysteine, improve insulin sensitivity, decrease infections in lung diseases, and help prevent kidney stones. (references, such as they exist for these claims). Data from rats suggest NAC could prevent the decrease in kidney function sometimes caused by lithium.
Glutathione Precursors Supplementation Mechanism 1 Cysteine is an important ingredient, the limiting one in fact, for the creation of glutathione. Glutathione is an "anti-oxidant", one of the primary ones. These molecules clean up chemical debris in cells, to oversimplify quite a bit. Research suggests that people with depression have too little glutathione. Using NAC is really just a way to try to raise the glutathione levels. Glutathione (GSH, L-gamma-glutamyl-L-cysteinylglycine) is the predominant anti-oxidant in the cytoplasm of cells. Virtually all cells require glutathione for viability and function. Glutathione is synthesized from three amino acids in a two-step process, beginning with the combination of glutamic acid & cysteine and ending with the addition of glycine. The liver & lungs are the primary sites of glutathione synthesis. Glycine & glutamic acid are plentiful in cells, so it is the availability of cysteine that controls the reaction rate. Mechanism 2 Another amino acid, glutamate, acts as a neurotransmitter (serotonin is another neurotransmitter you are probably more familiar with). Too much glutamate activity is not good, and that may be part of the problem in mood and anxiety disorders. Well, it turns out that cysteine can lower the amount of glutamate stimulation getting through to some neurons. It does so through a close relationship with glutamate, in in which it affects the balance between the two amino acids in brain neurons (I know, that was really vague. But this "cotransport" story is even more complicated, and I cannot really explain it well, yet). Changing cysteine levels can change this cysteine/glutamate balance -- to the good, it appears, for people with mood and anxiety problems. Contact Us NesvitalitySdnBhd No. 33A-G & 35-G, Block C, No.1, Jalan SS7/26, Kelana Jaya, 47301 Selangor DarulEhsan. Phone: +603-78866898 Email: firstname.lastname@example.org
Calcification Inhibitors in CKD and Dialysis Patients
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