Published on February 24, 2014
Abnormal signal transduction Loss of apoptosis Angiogenesis Metastasis
EGF EGFR VEGF IGF1 EGFR EGFR EGFR EGFR EGFR VEGFR IGF1R RTK EGFR EGFR EG FR
Signal transduction pathways: PI3K/Akt/mTOR MAPK
Activation of TNF receptor family DNA damage Extrinsic pathway (Death receptor) Intrinsic pathway (Mitochondrial) Caspases enzymes
Caspases enzymes Apoptosis Activated IAP proteins Bcl-2 family
Caspases enzymes Apoptosis Inhibited IAP proteins Bcl-2 family Over expression of NFkB
So the Heroes?
Less angiogenesis Common Drugs Cancer Drugs Dietary factors William Li, TED 2010
M.-H Pan et al, Cancer prevention by diet therapy, 2013
Hazard ratio for CRC NIH-AARP Diet and Health study: Folate intake and CRC risk n=567,000 Gibson et al, AJCN, 2011 Total folate (µg)
Pan et al, Harvard School of Public Health, 2012
#1: Focus on plant based foods
#2: Reduce meat intake
#3: Bulk up on fiber
#4: Know cancer fighting foods
#5: Prepare your food in healthy ways
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