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Food and Cancer: What is the story?

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Information about Food and Cancer: What is the story?
Health & Medicine

Published on February 24, 2014

Author: shayanmm

Source: slideshare.net

Description

This is a keynote lecture delivered in the 3rd American Society for Nutrition Middle East Congress, Dubai, UAE, Feb 2014.
The lecture was mainly focused on the effect of different bioactive food compounds on cancer, promoting diet therapy as a key component of cancer treatment.
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Abnormal signal transduction Loss of apoptosis Angiogenesis Metastasis

EGF EGFR VEGF IGF1 EGFR EGFR EGFR EGFR EGFR VEGFR IGF1R RTK EGFR EGFR EG FR

Signal transduction pathways: PI3K/Akt/mTOR MAPK

Activation of TNF receptor family DNA damage Extrinsic pathway (Death receptor) Intrinsic pathway (Mitochondrial) Caspases enzymes

Caspases enzymes Apoptosis Activated IAP proteins Bcl-2 family

Caspases enzymes Apoptosis Inhibited IAP proteins Bcl-2 family Over expression of NFkB

So the Heroes?

Less angiogenesis Common Drugs Cancer Drugs Dietary factors William Li, TED 2010

M.-H Pan et al, Cancer prevention by diet therapy, 2013

Hazard ratio for CRC NIH-AARP Diet and Health study: Folate intake and CRC risk n=567,000 Gibson et al, AJCN, 2011 Total folate (µg)

Pan et al, Harvard School of Public Health, 2012

www.en.omegart.org/MeatlessMonday

#1: Focus on plant based foods

#2: Reduce meat intake

#3: Bulk up on fiber

#4: Know cancer fighting foods

#5: Prepare your food in healthy ways

Final words…

www.omegart.org Shayan.m.moradi@omegart.org

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