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Electrophysiological assessment of neuromuscular transmission

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Information about Electrophysiological assessment of neuromuscular transmission
Health & Medicine

Published on February 19, 2014

Author: drrahulkumarsingh

Source: slideshare.net

Description

The Presentation discusses the detailed aspects of the Electrophysiological Aspects of Neuromuscular transmission, as well as the diagnostic features of the various types of NMJ Disorders.
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Acetyl co A +Choline Cholineacetylase Ach synthesis Main store Mobilization pool Immediately available pool ACh->Acetic acid+choline Depolarisation->EPP->MAP

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Myasthenia Gravis Repetitive Nerve Stimulation

baseline Post exercise 2 minutes 3 minutes Repeat exercise

Single Fiber EMG Myasthenia Gravis

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Ca2+ channel structure α2δ γ β α1

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

Action potential Arrival of an action potential at the synaptic terminal Axon Arriving action potential Synaptic terminal Sarcolemma Vesicles ACh Synaptic cleft Sarcolemma of motor end plate AChE molecules ACh receptor site ACh binding at the motor and plate Release of acetylcholine Vesicles in the synaptic terminal fuse with the neuronal membrane and dump their contents into the synaptic cleft. Muscle fiber The binding of ACh to the receptors increases the membrane permeability to sodium ions. Sodium ions then rush into the cell. Appearance of an action potential in the sarcolemma An action potential spreads across the surface of the sarcolemma. While this occurs, AChE removes the ACh. Action potential Na+ Na+ Na+

SCS

Choline acetyl transferase deficiency

20 Hz

Summary

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