Information about EGR 183 Final Presentation

Short (expert) version powerpoint summarizing research paper file 'Paper EGR 183 Modeling Neural Networks in silico'.

Background: Neurons

Background: LTP and LTD The mechanisms of Long-term Potentiation

The mechanisms of Long-term Potentiation

Background continued: The mechanisms of Long-term Depression

The mechanisms of Long-term Depression

Short-term and Long-term Effects

The Basis of Hebbian Learning

Foundation for our Computer Model

Types of Neuron Inhibitory Neurons Input Neuron Output Neuron Neuron is voltage-clamped, presynaptic to all neurons in model Inhibitory neurons depress post-synaptic neurons Excitatory Neurons Average firing rates solved at each time step Learning rule determines change in synaptic strength inhibitory synapse excitatory synapse Key: 1 2 3 4 α = - 1 4

Synaptic strengths 1.0 1.0 t=t 0 t=t 0+1 + α In phase Out of phase + α Two neurons are firing full-speed: Strengths increase by factor of alpha 1.0 0.0 - β One neuron v i is firing but v j is not: Strengths decrease by factor of beta - β v i v j v i v j v i v j v i v j

Inhibitory Neurons t=t 0 t=t 0+1 Excitatory Inhibitory = ...+ w i,j v i +... = ...- w i,j v i +... An inhibitory neuron v i is firing, depressing the post-synaptic neuron Weighted v i is summed negatively into v j Weighted v i is summed positively into v j An excitatory neuron v i is firing, potentiating the post-synaptic neuron v i v j v j v i v i v j v i v j

In-phase & out-of-phase components, but we could not teach the model complete phasic inversion Need further development to do this: one-way connections (i.e. some strengths are 0) Results

In-phase & out-of-phase components, but we could not teach the model complete phasic inversion

Need further development to do this: one-way connections (i.e. some strengths are 0)

Phase components Learning rule: α = | v 1 - v N | Input Neuron Output Neuron Convergence In phase component Out of phase component time firing rate

Learning rule: α = | v 1 - v N |

Output Neuron Maxima & Minima Local max near minimum Local min near maximum Maximum at maximum time firing rate Input Neuron

Further developments Short-term Sparse synapse matrix (i.e. some synapses are strength 0) Asynchronous firing Multi-dimensional training (i.e. for character recognition, sound recognition, etc.) Long-term Ca +2 Modeling Gene Expression Profile (DNA microarray data to reflect changes in synaptic efficacy)

Short-term

Sparse synapse matrix (i.e. some synapses are strength 0)

Asynchronous firing

Multi-dimensional training (i.e. for character recognition, sound recognition, etc.)

Long-term

Ca +2 Modeling

Gene Expression Profile (DNA microarray data to reflect changes in synaptic efficacy)

Biological parallel with In Silico Starvoytov et al. 2005 Light-drected stimulation of neurons on silicon wafers. J Neurophysiol 93 : 1090-1098.

LDS in concert with Computer Simulation MEAs vs. LDS More real-time data More quickly Scans: Works on variably connected neural networks

MEAs vs. LDS

More real-time data

More quickly

Scans: Works on variably connected neural networks

Short (expert) version powerpoint summarizing research paper file 'Paper EGR 183 Modeling Neural Networks in silico'.

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EGR 183 Final Presentation Short (expert) version powerpoint summarizing research paper file 'Paper EGR 183 Modeling Neural Networks in silico'.

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