Published on June 22, 2008
Author: arpanbhattacharya
Source: slideshare.net
Diabetes & Heart
Conventional Cardiac risk factors… superimposed on the diabetic state … Hypertension Microalbuminuria Inactivity South Asian origin Dyslipidaemia Obesity … further accentuate atherosclerosis in the diabetic state…accounting for the excess Cardiac risk
Why does diabetes predispose to atherosclerosis? Metabolic abnormalities…in diabetes High blood sugar High lipid Insulin resistance Alter the normal function of 3 different cell lines ARTERY … and their destruction leads to atherosclerosis Endothelial cell Platelet Smooth muscle cell
Metabolic abnormalities…in diabetes
Heart Attack Which patient is at greater risk of future attack? An attack survivor A typical Type 2 diabetic
Risk Factors and C.H.D. Adapted from : Stamler; Diabetes Care,12,573 (1989) Cholesterol. Smoking. Hypertension .
Heart Attack Equal risk An attack survivor A typical Type 2 diabetic Without heart problem
Atherosclerosis in T 2 DM ~80% of all people with Diabetes dying 75% from coronary atherosclerosis 25% from cerebral or peripheral vascular disease >75% of all hospitalizations are for diabetic complications . National Diabetes Data Group. Diabetes in America. 2nd ed. NIH;1995.
~80% of all people with Diabetes dying
75% from coronary atherosclerosis
25% from cerebral or peripheral vascular disease
>75% of all hospitalizations are for diabetic complications .
Death after MI Herlitz J et al, Acta Med Scand 1988
Managing Diabetes : 4 Cardinal Rules for the Patient 1. Follow a healthy meal plan 2. Regular exercise 3. Take your medication 4. Test your blood glucose regularly
1. Follow a healthy meal plan 2. Regular exercise
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