Challenging for Prevention Medicine 131129

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Information about Challenging for Prevention Medicine 131129
Health & Medicine

Published on January 26, 2014

Author: tmzo

Source: slideshare.net

Description

*For academia (research etc...) only.
How to calculate our life?

P = G + E

The Systems of Life and The Power of Statistics
(Interaction of Time, Space and Power )

Tomohisa Maruyama
Envirome, Inc.
CEO

予防ビジネスへの挑戦 How to calculate our life? どのように生命を計算するか? P=G+E The Systems of Life and The Power of Statistics (Interaction of Time, Space and Power ) 生命システムと統計の力 (時間と空間と力の相互作用) BaNZaI Tomohisa Maruyama President and CEO (Envirome, Inc.) Envelope? 2014/01/26 1

Index 0.はじめに • 自己紹介 • 0.In the beginning… - Self Introduction - My Personal History 1.生命の因子 • 健康は生命の基本 • 生命のシステムについて「スケール」 • 進化について「時というファクター」 • 家族(両親、兄弟姉妹) • 祖先について、日本の文化、風土 1. Factors of life - Health is the base of Life - Systems of Life (The factor “Scale”) - About Evolution (The factor “Time”) - Family (Parents, Brothers and Sisters) - Ancestor and Culture of Japan 2.表現型と遺伝子と環境子の統計学 • 生命の統計学 • 遺伝子とは • 遺伝子検査 妻とわたしの遺伝子の比較 2.Statistics (Phenome, Genome and Envirome) - Statistics of Life - Genome - Genetic Test Comparing gene between me and my wife • • • • • • 一卵性双生児の素晴らしい例 遺伝子の例 環境子の例 (モバイルアプリ等) 違いとはなにか?比較する。 環境子とは何か?文化について 自然、文化、未来 - Identical Twins - The case of genome - The case of envirome - Comparing us - About culture - Nature, Culture and Future Phenome = Genome +/* Envirome 2 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

0.はじめに 0.In the beginning… 3 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Q 1,099,511,627,776 3,200,000,000*2 医学研究者 130,000,000 会社社長 メディア etc…

Self Introduction 丸山 智久 / Tomohisa Maruyama <産業:Industry> *ENVIROME株式会社代表取締役兼CEO / Envirome Inc. - President and CEO URL; http://envirome.jp (Vision Making, Advanced Life Science and Data Mining) *美禅株式会社 取締役情報戦略兼広報戦略 / Bezen Inc. - CIO URL; http://www.wabezen.com (Culture Incubation, Culture Promotion and Japan Art) <学術:Academia> *東京医科歯科大学大学院 医歯学総合研究科 (がん等難病研究、長寿、老化研究) / Tokyo Medical and Dental University - Ph.D. Candidate – Medicine (Research about Cancer etc.) URL; http://www.tmd.ac.jp <メディア:Media> *日経BP外部記者 バイオ部 / Nikkei Business Publications – Writer (Biotechnology) URL; https://bio.nikkeibp.co.jp *菅野祐悟 グローバル戦略広報 / Yugo Kanno Director of Global Strategy and Publicity URL; www.yugokanno.com etc… FB; tomohisa.maruyama (Please contact me!) Twitter; tmzo (Please contact me!) 5 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

My Personal History / Koki 2638 2639 2640 2641 2642 2643 2644 2645 2646 2647 2648 2649 2650 2651 2652 / AC 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 / Age 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 / Address Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Hibari Kindergarten Hibari Kindergarten Hibari Kindergarten Kasumi West Primary Kasumi West Primary Kasumi West Primary Kasumi West Primary Kasumi West Primary Kasumi West Primary Kasumi West Jr High Kasumi West Jr High / Interest Living things and Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math 2653 1993 15 Kawagoe City, Saitama Pref Kasumi West Jr High Living things / Math 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Maebashi City, Gunma Pref Kiryu City, Gunma Pref Kiryu City, Gunma Pref Kiryu City, Gunma Pref Kiryu City, Gunma Pref Kawagoe City, Saitama Pref Kawagoe City, Saitama Pref Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Itabashi - ku, Tokyo Matsuyama High Matsuyama High Matsuyama High Gunma Univ Gunma Univ Gunma Univ Gunma Univ Gunma Univ Gunma Univ TUMSAT TUMSAT Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math Living things / Math 2654 2655 2656 2657 2658 2659 2660 2661 2662 2663 2664 2665 2666 2667 2668 2669 2670 2671 2672 2673 2014/01/26 / School / Job Part time Job Part time Job Part time Job IT IT IT IT IT IT IT IT IT Life Science AIST Life Science TMDU Life Science TMDU/HVDMU Life Science TMDU Life Science TMDU Life Science TMDU Life Science TMDU Life Science / Culture Copyright 2013 Tomohisa Maruyama , Envirome, Inc. 6

Index 0.はじめに • 自己紹介 • 0.In the beginning… - Self Introduction - My Personal History 1.生命の因子 • 健康は生命の基本 • 生命のシステムについて「スケール」 • 進化について「時というファクター」 • 家族(両親、兄弟姉妹) • 祖先について、日本の文化、風土 1. Factors of life - Health is the base of Life - Systems of Life (The factor “Scale”) - About Evolution (The factor “Time”) - Family (Parents, Brothers and Sisters) - Ancestor and Culture of Japan 2.表現型と遺伝子と環境子の統計学 • 生命の統計学 • 遺伝子とは • 遺伝子検査 妻とわたしの遺伝子の比較 2.Statistics (Phenome, Genome and Envirome) - Statistics of Life - Genome - Genetic Test Comparing gene between me and my wife • • • • • • 一卵性双生児の素晴らしい例 遺伝子の例 環境子の例 (モバイルアプリ等) 違いとはなにか?比較する。 環境子とは何か?文化について 自然、文化、未来 - Identical Twins - The case of genome - The case of envirome - Comparing us - About culture - Nature, Culture and Future Phenome = Genome +/* Envirome 7 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

1.生命の因子 1. Factors of life Interaction of Time, Space and Power 8 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

わたしたちは生物です。 We are living things. http://en.wikipedia.org/wiki/Evolution

健康は生命の基本 Health is the base of Life 10 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

100g 飲食したら100gの体重が増える わたしたちの身体は物質でできている If we ate 100g, Our weight will increase 100g. Our body is made from materials. http://en.wikipedia.org/wiki/Evolution

Life is Influenced by the system of …. 生命に影響を与えるシステム構成単位 Scale (Space) 0 m 0.素粒子 (Particle) 1.元素 (Element) 2.分子 (Molecule) 3.核酸 (Nucleotides) ← 3.2G*2 DNAs, RNA etc… 4.遺伝子 (Gene) ← 21,787遺伝子 身体の設計図(生命の傾向を予測可能) 5.たんぱく質 (Protein) ← 約100,000個 (アミノ酸コドン20種類) 6.染色体 (Chromosome) ← 22+X and 22+(X or Y) 計 46本 7.細胞 (Cell) ← 約60兆個?(体重ベース) 8.組織 (Tissue) 9.器官 (Organ) ←胃、肺、心臓、耳、脳、子宮、血管、骨等 10.器官系 (Organ System) ←循環器系、消化器系、神経系、呼吸器系、免疫 系、内分泌器系等 11.身体全体 (Whole body) 12.家族 (Family) 13.コミュニティー (Community) 14.地域 (Region) 15.国家 (State) 16.多国家地域(Multi-State Region) (アジア、ヨーロッパ、オセアニア、北アメリカ、南アメリカ… : Asia, Europe, Oceania, North America, South America ...) ) 17. 全世界(Worldwide) 10^23 m 18.太陽系 (Solar System) 銀河系 (Galaxy) ・・・・・・・ 10 to the 23rd meters …

Life is Influenced by the system of …. 生命に影響を与えるシステム構成単位 Scale (Space) 0 m 0.素粒子 (Particle) 1.元素 (Element) 2.分子 (Molecule) 3.核酸 (Nucleotides) ← 3.2G*2 DNAs, RNA etc… 4.遺伝子 (Gene) ← 21,787遺伝子 身体の設計図(生命の傾向を予測可能) 5.たんぱく質 (Protein) ← 約100,000個 (アミノ酸コドン20種類) 6.染色体 (Chromosome) ← 22+X and 22+(X or Y) 計 46本 7.細胞 (Cell) ← 約60兆個?(体重ベース) 8.組織 (Tissue) 9.器官 (Organ) ←胃、肺、心臓、耳、脳、子宮、血管、骨等 10.器官系 (Organ System) ←循環器系、消化器系、神経系、呼吸器系、免疫 系、内分泌器系等 11.身体全体 (Whole body) 12.家族 (Family) 13.コミュニティー (Community) 14.地域 (Region) 15.国家 (State) 16.多国家地域(Multi-State Region) (アジア、ヨーロッパ、オセアニア、北アメリカ、南アメリカ… : Asia, Europe, Oceania, North America, South America ...) ) 17. 全世界(Worldwide) 10^23 m 18.太陽系 (Solar System) 銀河系 (Galaxy) ・・・・・・・ バランスとリズムと力加減 Balance, Rhythm and Power Adjustment Fine Tuning 10 to the 23rd meters …

進化 Evolution - Scale (Time) http://en.wikipedia.org/wiki/Evolution

進化 Evolution http://ygraph.com/chart/1724

Envirome-Genome Analysis Sheet For your understand of yourself and Family あなた自身と大切な家族の理解のために 祖父母 : G-2 (Grandparents) Age 祖父母 : G-2 (Grandparents) Age Age Age Y Y 父母 : G-1 (Parents) Age 2 to the 4th power = 16 Ave. 25 years /generation 25 * 4 = 100 Years Y Age Age 1000 Years…. 2 to the 40th power is … 1,099,511,627,776 © 2013 Tomohisa Maruyama (Envirome, Inc.) All rights reserved.

文化 Culture http://ygraph.com/chart/1724

物質やさまざまなものが システム的に構成し流動しているものが生物である。 人間は情報・文化を利用することが出来る生物である。 We are made from Materials. We are living things. We are systems. We can use information. We can make culture. Scientific Name: Homo sapiens Linnaeus, 1758 : Animalia : Chordata : Vertebrata : Mammalia : Primate : Hominidae : Homo : H. sapiens doi:10.1038/nature10533

日本 Japan

わたしたちは生物です。 We are living things. http://en.wikipedia.org/wiki/Evolution

Index 0.はじめに • 自己紹介 • 0.In the beginning… - Self Introduction - My Personal History 1.生命の因子 • 健康は生命の基本 • 生命のシステムについて「スケール」 • 進化について「時というファクター」 • 家族(両親、兄弟姉妹) • 祖先について、日本の文化、風土 1. Factors of life - Health is the base of Life - Systems of Life (The factor “Scale”) - About Evolution (The factor “Time”) - Family (Parents, Brothers and Sisters) - Ancestor and Culture of Japan 2.表現型と遺伝子と環境子の統計学 • 生命の統計学 • 遺伝子とは • 遺伝子検査 • 妻とわたしの遺伝子の比較 • 遺伝子でどの程度までわかるか • 表現型,遺伝子と環境子 • 一卵性双生児の素晴らしい例 • 遺伝子の例 • 環境子の例 (モバイルアプリ等) • 違いとはなにか?比較する。 • 環境子とは何か?文化について • 自然、文化、未来 2.Statistics (Phenome, Genome and Envirome) - Statistics of Life - Genome - Genetic Test - Comparing gene between me and my wife - What we can know by our genome - Phenome, Genome and Envirome - Identical Twins - The case of genome - The case of envirome - Comparing us - About culture - Nature, Culture and Future Phenome = Genome +/* Envirome 21 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

2.表現型と遺伝子と環境子の統計学 2.Statistics (Phenome, Genome and Envirome) Interaction of Time, Space and Power 22 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

環境子とはなにか?遺伝子とはなにか? What is Envirome? What is Genome?

Statistics Interaction of Time, Space and Power 24 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

日本人の人口推移:発現子,環境子 Population of Japanese : Phenome, Envirome 25 10 1 1 2730 22 0.17 25 5 1 1 2731 14 1646 5 15 64 7935 5 65 3149 1 2575 4 http://www.stat.go.jp/data/jinsui/new.htm 21 2 15 3 122 9 117 24 3 0.17 0.92 1.52 3.86 0.19

日本人の睡眠習慣:環境子, 発現子 Japanese Sleeping time : Envirome, Phenome Reference: 2010 , http://www.nhk.or.jp/bunken/summary/research/report/2011_04/20110401.pdf

気温 Temperature : Envirome Health Care and ICT’s Ⅰ. VISION Ⅱ. NOW Ⅲ. BASE http://www.data.kishou.go.jp/climate/cpdinfo/himr/2011/chapter2.pdf

日本が世界に誇れる質と数:発現子、遺伝子、環境子、 Japan is Healthy Country : Phenome, Genome and Envirome Health Care and ICT’s Ⅰ. VISION Ⅱ. NOW Ⅲ. BASE www.thelancet.com Vol 380 December 15/22/29, 2012 Population 2013 B:405,938 J:127,817,277 S:5,183,700 SK:49,779,000

DNA, Gene and Genome DNA : 6.2 billions DNAs Gene : 21,787 Genome : 1 29 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Me and My wife’s DNA test result… 30 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

一卵性双生児の素晴らしい例 Identical Twins 31 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

32 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Daichi and Reiji Personal History / Koki / AC / Age / Address / School / Job / Interest / Differentation 2637 1977 0 Kunitachi City, Tokyo 2638 1978 1 Kunitachi City, Tokyo 2639 1979 2 Kunitachi City, Tokyo 2640 1980 3 Kunitachi City, Tokyo 2641 1981 4 Kunitachi City, Tokyo 2642 1982 5 Kunitachi City, Tokyo 2643 1983 6 Kunitachi City, Tokyo 2644 1984 7 Kunitachi City, Tokyo Kunitachi 1st Primary 2645 1985 8 Kunitachi City, Tokyo Kunitachi 1st Primary 2646 1986 9 Kunitachi City, Tokyo Kunitachi 1st Primary 2647 1987 10 Kunitachi City, Tokyo Kunitachi 1st Primary 2648 1988 11 Kunitachi City, Tokyo Kunitachi 1st Primary 2649 1989 12 Kunitachi City, Tokyo Kunitachi 1st Primary 2650 1990 13 Kunitachi City, Tokyo Kunitachi 3rd Jr.High Soccer / Basket Ball endurance + / - Speed +/++ 2651 1991 14 Kunitachi City, Tokyo Kunitachi 3rd Jr.High Soccer / Basket Ball endurance + / - Speed +/++ 2652 1992 15 Kunitachi City, Tokyo Kunitachi 3rd Jr.High Soccer / Basket Ball endurance + / - Speed +/++ 2653 1993 16 Aichi Pref Ichinomiya High Jyudo 2654 1994 17 Aichi Pref Ichinomiya High Jyudo 2655 1995 18 Aichi Pref Ichinomiya High Jyudo 2656 1996 19 Mitaka, Tokyo Tokyo Univ Smoking 2657 1997 20 Mitaka, Tokyo / Tokyo Tokyo Univ Smoking 2658 1998 21 Mitaka, Tokyo / Tokyo Tokyo Univ Smoking 2659 1999 22 Mitaka, Tokyo / Tokyo Tokyo Univ 2660 2000 23 Tokyo / Tokyo / Tokyo Univ 2661 2001 24 2662 2002 2663 Picture Design (Same) Smoking IT / / Snow board Smoking Tokyo / Tokyo IT / IT / Snow board Smoking 25 Tokyo / Tokyo IT / IT / Snow board Smoking 2003 26 Tokyo / Tokyo IT / IT / Snow board Smoking 2664 2004 27 Tokyo / Tokyo IT / IT / Snow board Smoking 2665 2005 28 Tokyo / Tokyo Free Trader (Finance)/IT / Snow board Married - / + Smoking 2666 2006 29 Tokyo / Tokyo Free Trader (Finance)/ Trader (Finance) / Snow board Married - / + Smoking 2667 2007 30 Tokyo / Tokyo Free Trader (Finance)/ Trader (Finance) / Snow board Married - / + 2668 2008 31 Tokyo / Tokyo Fashion Company IT / Trader (Finance) / Snow board Married - / + 2669 2009 32 Tokyo / Tokyo Fashion Company IT / Trader (Finance) Jogging / Snow board Married - / + 2670 2010 33 Tokyo / Tokyo Self Company / Trader (Finance) Jogging / Snow board Married - / + 2671 2011 34 Tokyo / Tokyo Self Company / Trader (Finance) Jogging / Snow board Married - / + 2672 2012 35 Tokyo / Tokyo Self Company / Trader (Finance) Jogging / Snow board Married - / + 2673 2013 36 Tokyo / Tokyo Self Company / Trader (Finance) Jogging / Snow board Married - / + 33 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Test : Phenome 34 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

環境子とはなにか?遺伝子とはなにか? What is Envirome? What is Genome?

Envirome-Genome Analysis Sheet For your understand of yourself and Family あなた自身と大切な家族の理解のために P-CMH(病歴): - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- 祖父母 : G-2 (Grandparents) Age Age Y P-CMH(病歴): 祖父母 : G-2 (Grandparents) P-CMH(病歴): - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- Age Y 父母 : G-1 (Parents) P-CMH(病歴): - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- 2 to the 4th power = 16 Ave. 25 years /generation 25 * 4 = 100 Years 1000 Years…. 2 to the 40th power is … 1,099,511,627,776 Age Y Age Age P-CMH(病歴): G- : - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress P-CMH(病歴): - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- 兄弟姉妹 及び 本人: G0 (Brothers, Sisters and You) Age P-CMH(病歴): - BML: - Allergy: E- Jobs: - Foods: - Location: - Stress G- 遺伝子全般:Genome = G 環境子(仕事):Envirome - Jobs = E^ J 環境子(食):Envirome - Foods = E^ F 環境子(ストレス):Envirome – Stress = E^ S フェノーム(体型):Phenome - Body Mass and Length = P^BML フェノーム(アレルギー):Phenome - Allergy = P^ A フェノーム(その他病歴) : Phenome - CaseMedical Histroy = P^ CMH © 2013 Tomohisa Maruyama (Envirome, Inc.) All rights reserved.

ヒトゲノムプロジェクト以降の遺伝子情報研究の発展 Genomic achievements since the Human Genome Project. Genomic achievements since the Human Genome Project. ED Green et al. Nature 470, 204-213 (2011) doi:10.1038/nature09764

遺伝情報を活用した将来 A vision for the future of Genome 14 April 2003 A vision for the future of genomics research Francis S. Collins, Eric D. Green, Alan E. Guttmacher & Mark S. Guyer Nature 422, 835-847 doi:10.1038/nature01626

これからの医療・医薬ヘルスケアに求められる もの Next Medicine and Healthcare will be … (Prevention and Personalized Medicine) IT (Ubiquitous Medicine with ICT) (Minimally invasive procedures ) http://www.moves-app.com/

Simulation Collective intelligence Please Think “What you are?”. あなたが何で出来ているかよく考えてください。 BC. 1,000,000

Simulation Collective intelligence 41 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

How Calcurate? 42 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Is there limit? 43 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

A 1,099,511,627,776 = 2^(40) 3,200,000,000*2 = DNAs of Human 医学研究者 130,000,000 = Japanese Population 会社社長 メディア etc…

Interaction of Space, Time and Power Please think about 自然; Nature 文化; Culture 未来; Future

11 26 Collective intelligence 46 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Special Thanks Family Identical Twins Translation Daichi Naomi Misa Reiji 47 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Phenome = Genome +/* Envirome We Can Calculate Our Life Thank You! ありがとうございます。 謝謝 This File will be uploaded on SNS and “envirome.jp”. You can share this. FB: tomohisa.maruyama Twitter:tmzo LinkedIn: tomohisa maruyama 2014/01/26 48

11 26 Collective intelligence 49 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

Today I talk about… ;Life • 遺伝子は生命の設計図です。数年以内にこの設計図情報を簡単に全て 知ることできるようになります。また、私たちは私たちの体の状態や 環境を測定することができ、それは私たち の生活の中で当たり前とな り、その意味をよく理解することができるようになりました。QSの動 きは私たちの生活ログの収集を加速しています。今回 Genome:遺伝要 因(遺伝子)とEnvirome:環境要因(環境子)の観点から私たちの生活 ログに関するいくつかの実例を紹介し、生命というシステムについて ;Life Log 考えます。 • The genome is the map of the life. Within these several years, it becomes possible to know easily.And also, we can measure our body’s status and the environment and which surrounds by our life , and it became able to be well understood.QS movements are accelerating to collecting our life logs.By the sight of “Genome; Genetic Factors” and “Envirome; Environmental factors”, I will show some case about our health log.And, we think about Data Mining ; “what is life?”. ; Big Data 50 2014/01/26 Copyright 2013 Tomohisa Maruyama , Envirome, Inc.

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