Ch 4: Membrane Potential

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Information about Ch 4: Membrane Potential
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Published on December 5, 2008

Author: wessellr

Source: authorstream.com

Slide 1: How Neurons Send and Receive Signals Chapter 4 Neural Conduction and Synaptic Transmission The Neuron’s Resting Membrane Potential : The Neuron’s Resting Membrane Potential Membrane – difference in electrical charge between inside and outside of cell Inside of the neuron is negative with respect to the outside Resting membrane potential is about –70mV Membrane is polarized (carries a charge) Ionic Basis of the Resting Potential : Ionic Basis of the Resting Potential Factors contributing to even distribution of ions (charged particles) Random motion – particles tend to move down their concentration gradient Electrostatic pressure – like repels like, opposites attract Factors contributing to uneven distribution of ions Selective permeability to certain ions Sodium-potassium pumps Ions Contributing to Resting Potential : Ions Contributing to Resting Potential Sodium (Na+) Chloride (Cl-) Potassium (K+) Negatively charged proteins (A-) Synthesized within the neuron Found primarily within the neuron The Neuron at Rest : The Neuron at Rest Ions move in and out through ion-specific channels K+ and Cl- pass readily Little movement of Na+ A- don’t move at all, trapped inside The Neuron at Rest (continued) : The Neuron at Rest (continued) Equilibrium Potential The potential at which there is no net movement of an ion – the potential it will move to achieve when allowed to move freely Na+ = 120mV K+ = 90mV Cl- = -70mV (same as resting potential) The Neuron at Rest (continued) : The Neuron at Rest (continued) Na+ is driven in by both electrostatic forces and its concentration gradient K+ is driven in by electrostatic forces and out by its concentration gradient Cl- is at equilibrium Sodium-potassium pump – active force that exchanges 3 Na+ inside for 2 K+ outside Slide 8: The passive and active factors that influence the distribution of Na+, K+, and Cl– ions across the neural membrane The Neuron at Rest (continued)

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