Central dogma

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Information about Central dogma

Published on June 15, 2008

Author: melamoon

Source: slideshare.net

PROTEIN Transcription Translation DNA RNA

Transcription of DNA to RNA to protein : This dogma forms the backbone of molecular biology and is represented by THREE major stages. 1. Replication. 2. Transcription . 3. Translation .

Transcription of DNA to RNA to protein : This dogma forms the backbone of molecular biology and is represented by THREE major stages.

1. Replication.

2. Transcription .

3. Translation .

Unwinding of DNA to produce a copy during a cell division. The enzymes involved were helicase,polymerase, RNA primase,ligase. The leading strand operate in a continous fashion Whereas the lagging strand is not in a continous fashion (okazaki fragments)

Unwinding of DNA to produce a copy during a cell division.

The enzymes involved were helicase,polymerase,

RNA primase,ligase.

The leading strand operate in a continous fashion

Whereas the lagging strand is not in a continous fashion (okazaki fragments)

Copying of part of DNA strand (base pair of a gene) by complementary base pairs. Only one strand of DNA (the template strand) is transcribed. RNA polymerase opens the part of the DNA to be transcribed.

Copying of part of DNA strand (base pair of a gene)

by complementary base pairs.

Only one strand of DNA (the template strand) is transcribed.

RNA polymerase opens the part of the DNA to be transcribed.

 

codon=3 base pairs= responsible for amino acid building blocks of amino acid=protein

The ribosome binds to the mRNA at the start codon (AUG) During this stage, complexes, composed of an amino acid linked to tRNA, sequentially bind to the appropriate codon in mRNA by forming complementary base pairs with the tRNA anticodon .

The ribosome binds to the mRNA at the start codon (AUG)

During this stage, complexes, composed of an amino acid linked to tRNA, sequentially bind to the appropriate codon in mRNA by forming complementary base pairs with the tRNA anticodon .

2 subunits (large and small) form a 3D groove 2 major sites: P site---holds the growing polypeptide A site---new amino acids enter here

2 subunits (large and small) form a 3D groove

2 major sites:

P site---holds the growing polypeptide

A site---new amino acids enter here

The ribosome moves from codon to codon along the mRNA. Amino acids are added one by one, translated into polypeptidic sequences dictated by DNA and represented by mRNA. At the end, a release factor binds to the stop codon, terminating translation and releasing the complete polypeptide from the ribosome.

The ribosome moves from codon to codon along the mRNA. Amino acids are added one by one, translated into polypeptidic sequences dictated by DNA and represented by mRNA.

At the end, a release factor binds to the stop codon, terminating translation and releasing the complete polypeptide from the ribosome.

 

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