Cell Cycle -1 Mitosis

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Published on February 21, 2018

Author: husanbano

Source: authorstream.com

Cell Cycle -1 Mitosis: Cell Cycle -1 Mitosis Prof. Husan Bano Department of Physiology Al- Tibri Medical College, Isra University Learning Objectives: Learning Objectives At the end of this lecture you should be able to: Define cell cycle. Explain the phases of cell cycle . Explain mitosis and its phases . List the importance of mitosis . Slide 3: Cell Cycle Cell Cycle: Cell Cycle Definition: It is the series of stages by which genetic materials are duplicated and cell is divided into two daughter cells having same genetic component as the parent cell. Phases of Cell Cycle : 1. G1 Phase (Gap-1) 2. S- Phase ( DNA synthesis) 3. G2 Phase (Gap-2) 4. M-Phase (Mitosis) Phases of Cell Cycle: Phases of Cell Cycle Cell Cycle Cont….: Cell Cycle Cont…. G1 phase Cell is prepared for division. Cellular contents excluding chromosomes duplicated. S phase DNA synthesis replicates the genetic material. Each 46 chromosome duplicate and form two sister chromatids . Cell Cycle Cont….: Cell Cycle Cont…. G2 phase Each duplicated chromosomes checked . If there is error, it is repair in this phase. M phase Mitosis takes place. A nuclear division (mitosis) followed by a cell division ( cytokinesis ). Slide 8: Mitosis Slide 9: Note: Before going in detail about mitosis, some terminology must be known. Terminology: Terminology Chromatin - thin fibrous form of DNA and proteins. Sister chromatids - identical structures which are produce from chromosome replication. Structure of Chromosome: Structure of Chromosome Centromere – point where sister chromatids are joined together P =short arm; upward Q =long arm; downward Telomere -tips of chromosome p -arm centromere q-arm telomere chromatids Mitosis: Mitosis Definition: Mitosis is a cell division in which parent cell is divided in two daughter cells having the same number and kind of chromosomes as the parent nucleus. Stages of Mitosis : Stages of Mitosis 4 stages : Prophase Metaphase Anaphase Telophase . 1. Prophase: 1. Prophase Chromosome condense. Microtubules form. The nuclear envelope breaks down. 2. Metaphase: 2. Metaphase Chromosomes are pulled to center of cell. Line up along “metaphase plate”. 3. Anaphase: 3. Anaphase Centromeres divide. Spindle fibers pull one set of chromosomes to each pole. 4. Telophase: 4. Telophase Nuclear envelope form around chromosomes. Chromosomes uncoil. Cytokinesis takes place. (Cell divide into two) Slide 18: Mitosis begins after G 2 and ends before G 1 Slide 19: Importance of Mitosis. Importance of Mitosis (Why Do Cells Divide?) : Importance of Mitosis ( Why Do Cells Divide?) Mitosis is important for: Growth of cell. Repair of cell. Reproduction of cell. Cell Division vs. Nuclear Division: Cell Division vs. Nuclear Division Cytokinesis : The actual division of the cell into two new cells. Mitosis : The division of the nucleus of the cell into two new nuclei. Note : Sometimes cells go through mitosis without going through cytokinesis . Name the cell that did this. Slide 22: Thanks

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