Published on February 22, 2014
Carcinoid Tumours Dr. Ahmed Almumtin
Introduction The term “carcinoid” “Carcinoid syndrome” vs “carcinoid tumour”
Epidemiology Carcinoids are relatively rare tumors. incidence 4.7:100,000 median age 63 male : female is it really increasing?
Pathology and grading Origin. Different behaviour. Grading vs differentiation. Two sub-Groups: Well differentiated Poorly differentiated
Embryonic classification Based on Embryonic origin Foregut - stomach Midgut - Small intestine, Appendix Hindgut - Colon, Rectum, Genitourinary, Ovarian .. Metastatic
WHO Classification Te xt - Well differentiated: • Low grade • Intermediate Grade - Poorly differentiated • High grade
Continue classification European Neuroendocrine Tumour Society (ENTS) vs American Joint Committee on Cancer (AJNCC) vs WHO.
Carcinoid Syndrome Definition Pathophysiology - mediators Tryptophan Metabolism Histamine Killekrien Prostaglandins Tachykinins Clinical features
Clinical Features of carcinoid syndrome Cutaneous flushing Venous telangiectasia diarrhoea bronchospasm cardiac valvular lesions
So, patient presents as a result of the carcinoid syndrome or as a result of tumour growth or as incidental finding
Diagnosis Biochemical testing: Urinary 5-HIAA Urinary Serotonin serum chromogranin Serum serotonin Tumour localisation CT MRI Scintigraphy OctreoScan PET scan Endoscopy
Basic principles of evaluation and management of patients with carcinoid tumours Radiographic Staging and Localisation Pathologic assessment of tumour differentiation and/or grade Removal of Tumour Control of carcinoid symptoms
Treatment of Localised Carcinoids - Appendix - Small intestine - Rectum - Colon - Stomach
Appendix Size >2 cm < 2cm Appendectomy vs Rt hemicolectomy
Small intestine Usual location. Matastasis prognosis
Rectum Treatment < 1 cm mucosa or submucosa > 2 cm or beyond muscolaris propria Prognosis
Colon Aggressive 5 years survival prognosis
Stomach Types options Medical therapy?
Prognosis Stage and Site of origin Tumour differentiation
Post-treatment F/U Gastric, Small intestine, Colonic, appendiceal and Rectal 3 to 12 months.. more than one year Gastric <= 2 cm
Te xt Thank you
Carcinoid (also carcinoid tumor) is a slow-growing type of neuroendocrine tumor originating in the cells of the neuroendocrine system. In some cases ...
Unter dem Begriff Karzinoid versteht man in der Medizin eine bestimmte Sorte von neuroendokrinen Tumoren (NET). Die typischen Symptome, die im Rahmen von ...
Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells in the gut wall, but they can be seen in other organs,  ...
Carcinoid tumours are neuroendocrine tumours (NETs). Two thirds of carcinoid tumours occur somewhere in the gastrointestinal tract.
A Carcinoid is a tumour of the neuroendocrine system, which is a series of glands that produce hormones that are carried in the bloodstream.
Ein Karzinoid (neuroendokriner Tumor) ist ein sehr seltener bösartiger Tumor, der sich von bestimmten hormonbildenden Zellen ableitet. Karzinoide treten ...
What are carcinoid tumours? Carcinoids are rare tumours which tend to be slow growing. They may not cause any symptoms for several years. Most of these ...
Carcinoid tumors are rare, slow-growing cancers. They usually start in the lining of the digestive tract or in the lungs. They grow slowly and ...
1 Definition. Karzinoid ist eine Sammelbezeichnung für Tumoren, die aus Zellen des diffusen neuroendokrinen Systems hervorgehen. In einer WHO ...
The Carcinoid Cancer Foundation pledges to continue working to bring about greater awareness of carcinoid and NET cancers; to educate the medical community ...