Caliciviridae

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Information about Caliciviridae
Education

Published on March 9, 2014

Author: jclargado

Source: slideshare.net

• from the Latin calyx “chalice” or Cup • Often referred as “Small round structured viruses”

• • • • non-enveloped 27-40 nm in diameter Icosahedral symmerty Some have characteristic appearance with 32 cup shaped depressions on their surface • Linear • Positive sense single-stranded RNA viruses

Encompasses 4 clinical syndromes: • Swine Vesicular Exanthema • San Miguel Sea Lion Virus • Feline Calicivirus • Rabbit Hemorrhagic Disease

Group IV; single stranded RNA positive-strand viruses Family: Caliciviridae Genus: Lagovirus Nebovirus Norovirus Sapovirus Vesivirus

1.Attachement to host receptors mediates e ndocytosis of the virus into the host cell. 2.Uncoating, and release of the viral genomic RNA into the cytoplasm.

3.VPg is removed from the viral RNA, which is then translated into a processed ORF1polypr otein to yield the replication proteins. 4.Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).

5. The dsRNA genome is transcribed/replicate d thereby providing viral mRNAs/new ssRNA(+) genomes. 6. Subgenomic RNA tran slation gives rise to the capsid protein and VP2.

7. Assembly of new virus particles and release by cell lysis.

• Swine Vesicular Exanthema • San Miguel Sea Lion Virus • Feline Calicivirus • Rabbit Hemorrhagic Disease

Vesicular Exanthema infection of Porcine

Rabbit Hemorrhagic Disease

 a common respiratory disease in cats  virus attacks the respiratory tract -- lungs and nasal passages -- the mouth, with ulceration of the tongue, the intestines, and the musculoskeletal system

Causative agent: Clinical Signs: conjunctivitis rhinitis tracheatis pneumona and vesiculation, ulceration of the oral epithelium fever anorexia lethargy stiff gait

Nasal discharge and vesicles & ulcers on the tongue of a cat infected with FCV.

Tongue ulcerative glossitis from a FCV case.

Lesions: on muzzle and tongue, respiratory tract, oral cavity and eyes. Pathogenesis: natural transmission occurs via aerosol and fomites; the virus is often carried to susceptible cats by human handlers.

Radiographs of interstitial pneumonia.

Histopathology & gross pathology of interstitial pneumonia from a FCV case.

Lymphocytic-plasmacytic stomatitis in a cat.

Lesions in the eyes

DISEAS CAUSATI ES VE AGENT SAMPLE/s DIAGNOSTIC TEST SWINE VESICULAR EXANTHEMA VESIVIRUS Vesicular fluid, mucous membranes SEROLOGIC TEST ELECTRON MICROSCOPY FELINE CALICIVIRUS VESIVIRUS oral swabs, blood, skin scrapings or lung tissue PCR, IMMUNOFLOURESCENCE ENZYME IMMUNOASSAY RABBIT HEMORRHA GIC DISEASE LAGOVIRUS Spleen, liver , blood IMMUNOFLOURESCENCE ENZYME IMMUNOASSAY SAN MIGUEL SEA LION VIRUS VESIVIRUS Tissue samples, fecal samples ELISA Immunoflourescence PCR

 There is no specific treatment for FCV  Antibiotics are used for secondary bacterial infections, and immune modulators, such as lymphocyte T-cell immune modulator, have been used for immune support.

 Nursing care and rehydration are used for dehydrated and anorexic cats  Routine vaccination. Avoiding overcrowding of feline populations, reducing stress.

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