Calcium

43 %
57 %
Information about Calcium
Health & Medicine

Published on March 27, 2014

Author: mprasadnaidu

Source: slideshare.net

Description

Minerals

M.Prasad Naidu MSc Medical Biochemistry, Ph.D.Research Scholar

Total body Calcium 1 – 1.5 kg 99% in Bones &Teeth 1% in body Fluids and tissues

Milk and dairy products Eggyolk , Fish, G.L.V , beans Cow’s milk 100mg/100ml Human milk 30mg/100ml

RECOMMENDED DAILY ALLOWANCE (RDA): Adults – 500 mg /day Children - 1200 mg /day Pregnancy & 1500 mg /day Lactation

SITE : first part and second part of duodenum Calcium absorbed against concentration gradient and requires energy and a carrier protein.

Factors affecting absorption: INCREASE THE ABSORPTION RATE 1.CALCITRIOL 2. PARATHYROID HORMONE 3.ACIDITY 4.AMINOACIDS – Lysine and Arginine

FACTORS THAT DECREASE ABSORPTION RATE: 1.PHYTATES 2.OXALATES 3.HIGH PHOSPHATE CONTENT OPTIMUM RATIO OF CALCIUM TO PHOSPHATE CONTENT– 1:2 TO 2:1----- allows maximum absorption. 4.FREE FATTY ACIDS ( FFA) Ca+ FFA – In soluble calcium soaps (Steatorrhoea) 5. ALKALINE MEDIUM 6. HIGH DIETARY FIBRE

1.Mineralisation of Bones and teeth. Bone is a mineralized connective tissue. It contains organic (collagen – protein) and inorganic (mineral) Component, HYDROXY APATITE, Ca10(Po4)6 (OH)2

. - Calcium is factor IV in coagulation cascade. Prothromlin (factor II) contains Gla(γ Carboxy glutamate) Residues. Calcium forms a bridge between Gla residues of prothrombin and membrane phospholipids of platelets

Calmodulin is a Calcium binding regulatory protein molwt 17000 Calmodulin can bind with 4 calcium ions

Mechanism of action of Calcium

Mediated by Calmodulin 1. Adenyl cyclase 2. Ca++ dependent protein kinases 3. Ca++ -Mg++ ATPase 4. Glycogen synthase 5. Phospholipase C 6. Phosphorylase kinase 7. Pyruvate carboxylase 8.Pyruvate dehydrogenase 9. Pyruvate kinase.

Mediated by Calmodulin 1. Adenyl cyclase 2. Ca++ dependent protein kinases 3. CA++ -Mg++ ATPase 4. Glycerol – 3 – phosphate dehydrogenase 5. Glycogen synthase 6. Phospholipase C 7. Phosphorylase kinase 8. Pyruvate carboxylase 9. Pyruvate dehydrogenase 10. Pyruvate kinase.

Calcium is necessary for transmission of nerve impulses from pre-synaptic to post – synaptic region. Calcium mediates secretion of Insulin, parathyroid hormone, calcitonin, vasopressin,etc. from the cells

Calcium and cyclic AMP are second messengers of different hormones . One example is glucagon. Calcium is used as second messenger in systems involving G proteins and inositol triphosphate.

8. MYOCARDIUM In myocardium, Ca++ prolongs systole. In hypercalcemia cardiac arrest is seen in systole. Caution : when calcium is administered intravenously, it should be given very slowly.

Normal serum level of calcium -- 9 to 11 mg /dl Ionized calcium -- 5 mg/dl Calcium complexed with Po4, citrate -- 1 mg/dl Protein bound Calcium -- 4 mg/dl IONIZED CALCIUM IS METABOLICALLY / BIOLOGICALLY ACTIVE FORM.

 Hypoalbuminemia results in of plasma↓ total Calcium levels  Each 1gm of Albumin causes of 0.8mg/dl↓ ↓ of Calcium  Hyperproteinemias (paraproteinemia) are associated with plasma total Calcium level↑  Acidosis favours release of ionized Calcium.  Alkalosis favours binding of Calcium and decreases ionized Calcium level,but total calcium is normal.

Calcium homeostasis : Plasma calcium is maintained within narrow limits. Major factors involved in homeostasis 1.Calcitriol - increase calcium 2.Parathormone - increase calcium 3. Calcitonin - decrease calcium

Parathormone •Secreted by chief cells of parathyroid. •Release of PTH is mediated by c-AMP. •Three independent sites of action. they are bone , kidney and intestine. •All the 3 actions of PTH increase serum calcium level.

BONE : • acts directly on bone. • causes demineralisation /decalcification • increases number of osteoclasts and induces pyrophosphatase in them. • osteoclasts release lactate into surrounding medium which solubilise calcium and move it into ECF. •Also secretes collagenase from osteoclasts which cause loss of matrix and bone resorption

KIDNEY PTH has direct action .  decreases renal excretion of calcium ( mainly by increased reabsorption of calcium from distal tubules)and increases phosphate excretion.

Intestine PTH stimulates 1 –hydroxylation of 25-cholecalciferol Forms calcitriol Calcitriol induces synthesis of calbindin Calbindin increase calcium absorption from intestine Thereby increasing calcium level in blood.

Calcitonin : secreted by parafollicular cells of thyroid.  Calcitonin promotes calcification by increasing the activity of osteoblasts.  Calcitonin decreases bone resorption.  It increases the excretion of Ca in urine.  Overall it decreases blood Ca level.

GUT vitamin D PTH PTH PTH BONE serum calcium reabsorption of of calcium vitamin D, calcitonin from kidney tubules HOMEOSTASIS OF SERUM CALCIUM

Importance of Ca : P ratio Product of Ca x P ( 10 x 4 ) Normal Adults – 40 Children – 50 <30 Rickets Normal Ca : P ratio is essential for bone mineralisation.

Hypercalcemia : causes : 1.hyperparathyroidsm – characterised by increase serum calcium decrease in serum phosphate and increase in alkaline phosphatse activity. 2. Multiple myeloma 3. Pagets disease 4. Secondary bone cancer

Clinical features of Hypercalcemia  Neurological symptoms Depression, Confusion, irritability  Generalised MuscleWeakness  GIT : Anorexia Abdominal Pain Nausea Vomiting  CVS: Cardiac arrythmias

Hypocalcemia: serum calcium level < 8.8 mg/dl ---- hypocalcemia. Serum calcium level < 7 mg/dl -- TETANY. Causes: 1.accidental surgical removal of parathyroid 2. Pseudohypoparathyroidism – lack of end organ response 3.Renal disease 4. Liver disease 5. Vitamin D deficiency

6. Malabsorption syndromes 7. Renal rickets 8. osteoporosis Clinical features of Tetany: •Neuromuscular irritability •Spasms- laryngeal spasm lead to death. •Convulsions •Muscular cramps ECG changes –Q-T interval increased

Add a comment

Comments

The Jewelry Store | 17/01/15
Cool article, It was inspiring. The Jewelry Store http://www.e2by.info/
Acetamiprid | 17/01/15
Cool article, It was inspiring. Acetamiprid http://www.jinweichem.com/Insecticide/product_73.html
cheap watch store | 17/01/15
Cool article, It was practical. cheap watch store http://www.the-great-watch.com/
Ultramarine blue | 17/01/15
Cool article, It was practical. Ultramarine blue http://www.hbjwchem.com/PigmentsDyes/product_11.html

Related presentations

Related pages

Calcium – Wikipedia

Calcium, oder Kalzium, ist ein chemisches Element mit dem Elementsymbol Ca und der Ordnungszahl 20. Im Periodensystem steht es in der zweiten Hauptgruppe ...
Read more

Calcium – Calciummangel begegnen - Gesundheit ist für ...

Leiden Sie an Calciummangel? Benötigen Sie ein Calcium-Präparat? Wenn ja, welches? Dies und viele weitere Infos rund um das Calcium erfahren Sie bei uns.
Read more

Calcium = Kalzium: Bedarf, Mangel, Überversorgung

Calcium = Kalzium: Calcium = Kalzium ist wichtig für den Aufbau von Knochen und Zähnen, die Übertragung von ...
Read more

Kalzium | Calcium - gesundheit.de

Kalzium: Wirkung und Eigenschaften. Die Hauptaufgabe von Kalzium, das auch Calcium genannt wird, ist es, im Körper Hartgewebe zu bilden. Dadurch ist es ...
Read more

Calcium - Onmeda.de

Calcium (auch: Kalzium) zählt zu den Mineralstoffen. In der Regel lässt sich der tägliche Calciumbedarf problemlos über die Ernährung
Read more

Calcium Calciumhaltige Lebensmittel - Onmeda.de

Käse, Milch und andere Milchprodukte liefern die größten Mengen an Calcium. Aber auch pflanzliche Lebensmittel enthalten Calcium
Read more

Calcium - Nährstoffe-Lexikon A-Z | jameda

Calcium ist mengenmäßig unser wichtigster Mineralstoff . 99 % des gesamten Calciumbestandes im Körper finden sich in den Knochen, kleinere Mengen in den ...
Read more

Calcium - Wikipedia, the free encyclopedia

Calcium is a chemical element with symbol Ca and atomic number 20. Calcium is a soft gray alkaline earth metal, fifth-most-abundant element by mass in the ...
Read more

Calciummangel Symptome - Calciumbedarf: Wieviel Calcium ...

Calciummangel - Calciumbedarf: Wieviel Calcium brauchen wir wirklich? Über neun Millionen Packungen Calciumpräparate gehen jedes Jahr über die ...
Read more

Calcium-Sandoz® D Osteo - Mineralien & Vitamine - Calcium ...

Mit Calcium-Sandoz® D Osteo sind Sie gut versorgt mit Calcium und Vitamin D.
Read more