Cal polypoPreliminary studies of preparation of ferrite nanoparticles and the hyperthermia property in simulated tissuesmona ubm-nanoparticles-2-13-14

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Information about Cal polypoPreliminary studies of preparation of ferrite nanoparticles...
Health & Medicine

Published on February 22, 2014

Author: UBMCanon

Source: slideshare.net

Description

Dr. Yong Gan, Associate Professor, California State Polytechnic University, Pomona

Sophia Chan, Eric Duong, Yong X. Gan Department of Mechanical Engineering California State Polytechnic University Pomona February 13, 2014

• Understand the theory and fabrication of nanoparticles • How nanoparticles are applied to cancer treatment

• Research was first done to understand how nanoparticles are used in cancer treatment • How did the heat generated by nanoparticles aid cancer treatment

• Chemotherapy - Necrosis Factor Alpha (TNF) are attached to gold nanoparticles with Thiol-derivatized Polyethylene Glycol • Heat Generation - Absorbtion of infrared light from a laser produces heat generation in the nanoshells • Combination (Chemotherapy and Heat Generation) - Nanoparticles act as a drug carrier while a laser produces heat generation

• Also known as magnetic nanoparticles • Exhibits valuable physical and chemical characteristics that can be used in numerous applications in biomedicine - Cell seperation Drug delivery Magnetic Resonance Imaging (MRI) Hyperthermia

• Magnetic nanoparticles are first mixed within a carrier fluid(medicine) • Direct injection or tumor specific antibody targeting is then applied to target the tumor • Using various instruments, the tumor is then exposed to an alternating magnetic field to generate heat by magnetic relaxation mechanisms

Ethylene glycol Ammonium flouride Deionized water Power supply

• Making the Solution • 95% Ethylene glycol • 1% Ammonium flouride • 4% Deionized water • Power supply • Kept at 12 Volts • Process time • 24-48 hours

• Takes too long • Very little nanoparticles made • Wastes electricity, since it needed more than12V of power to excite the electrons of the iron rod • Solution will get old, so constant of changing is required • Since if the solution works best and fastest when it is fresh

• Iron (III) nitrate nanahydrate • potassium hydroxide

• Preparing the solution • Iron (III) nitrate nanahydrate, ACS, 98.0-101.0% • Potassium hydroxide (P5958-250G) 2% • Solution precipitates • Iron oxide (Fe2O3/FeO/Fe3O4)

• Put the solution in the centrifuge machine • To separate the precipitate with solution • Collecting the precipitate and letting it dry • The dried precipitate is the nanoparticles used for experiment

• Trying to prove that MNP in different quantities can reach high temperatures in less time • Procedure • Heat one sample at a time • In a time interval of 1 second • Take temperature reading • Let it set cool to the initial temperature • Repeat same above steps for the consecutive second

• • • • Sample 1 and 2 Sample 3 Sample 4 Sample 5 Sample 1and 2 Sample 3 Sample 4 Sample 5 • Specimen schematic

200 180 160 Temperature (˚F) 140 120 Sample 1 100 Sample 2 Sample 3 80 Sample 4 Sample 5 60 40 20 0 0 1 2 3 Differential Time (sec) 4 5

0.0007 Heat Transfer (BTU/hr-ft^2) 0.0006 0.0005 0.0004 Sample 3 Sample 4 0.0003 Sample 5 0.0002 0.0001 0 0 2 37 66 Differential Temperature (˚F) 116

• MNP has a unique magnetic property • Heating Mechanism • No specific proof of how it works • There are 3 assumptions • The initial assumption for heating mechanism is the susceptibility loss. • The other heating mechanism that starts to be activated is the hysteresis loss • Viscous heating or magnetic stirring

• Time is always the most golden factor for cancer treatment • Electromagnetic waves were to excite the magnetic nanoparticles • To force them through the phase of the delay in the relaxation of the magnetic moment through either the rotation within the particle or the rotation of the particle itself • Different losses that goes through that blocks off magnetic nanoparticles and the moments that cannot switch were the reasons behind the generation of heat was beneficial

• NSF Grant No. CMMI-1333044 • CAFA Faculty Development Grant • Cal Poly Pomona 2013-2014 RSCA Program

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